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View article: Predicting Pulmonary Exacerbations in Cystic Fibrosis Using Inflammation-Based Scoring Systems
Predicting Pulmonary Exacerbations in Cystic Fibrosis Using Inflammation-Based Scoring Systems Open
Background: The aim of this study is to identify people with cystic fibrosis (pwCF) at risk for future pulmonary exacerbations (PEx) based on established and unestablished markers of chronic inflammation. There is currently no universal de…
View article: Use of inhaled corticosteroids in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC)
Use of inhaled corticosteroids in bronchiectasis: data from the European Bronchiectasis Registry (EMBARC) Open
Introduction Current bronchiectasis guidelines advise against the use of inhaled corticosteroids (ICS) except in patients with associated asthma, allergic bronchopulmonary aspergillosis (ABPA) and/or chronic obstructive pulmonary disease (…
View article: Toxicity Profile and Efficacy of Docetaxel Following Paclitaxel- or Pemetrexed-Platinum Chemotherapy Alone or in Combination With Immune Checkpoint Inhibitors in NSCLC Patients: A Single Institution Retrospective Analysis
Toxicity Profile and Efficacy of Docetaxel Following Paclitaxel- or Pemetrexed-Platinum Chemotherapy Alone or in Combination With Immune Checkpoint Inhibitors in NSCLC Patients: A Single Institution Retrospective Analysis Open
Background Docetaxel alone or in combination with ramucirumab or nintedanib is recommended as second-line treatment in metastatic non-small cell lung cancer (NSCLC) patients after progression on first-line platinum-base chemotherapy in com…
View article: Classification and course of pulmonary hypertension associated with end-stage COPD
Classification and course of pulmonary hypertension associated with end-stage COPD Open
Background Pulmonary hypertension (PH) associated with COPD contributes to morbidity and mortality. Further characterisation to improve management is warranted. The aim of the study was to apply the recently proposed PH classification and …
View article: Current Blood Eosinophilia Does Not Predict the Presence of Pulmonary Hypertension in Patients with End-Stage Lung Disease
Current Blood Eosinophilia Does Not Predict the Presence of Pulmonary Hypertension in Patients with End-Stage Lung Disease Open
Objectives: To investigate the role of blood eosinophils in predicting PH in end-stage lung disease. Methods: We conducted a retrospective study of adults with CF, COPD, and ILD who underwent RHC during lung transplant evaluations (2010–20…
View article: Mucus Plug Score Predicts Clinical and Pulmonary Function Response to Biologic Therapy in Patients With Severe Asthma
Mucus Plug Score Predicts Clinical and Pulmonary Function Response to Biologic Therapy in Patients With Severe Asthma Open
Our study suggests that a higher MPS correlates with worse pulmonary function at baseline but also predicts a larger clinical and pulmonary function response to biologic therapies in severe asthma.
View article: Management erwachsener Patientinnen und Patienten mit Bronchiektasen-Erkrankung
Management erwachsener Patientinnen und Patienten mit Bronchiektasen-Erkrankung Open
Zusammenfassung Die Bronchiektasen-Erkrankung ist eine ätiologisch heterogene, chronische und oftmals progredient verlaufende Atemwegs- und Lungenerkrankung, die durch eine irreversible Erweiterung der Bronchien gekennzeichnet ist. Sie geh…
View article: Topotecan in a Real-World Small-Cell Lung Cancer Cohort: Prognostic Biomarkers Improve Selection of Patients for Second-Line Treatment
Topotecan in a Real-World Small-Cell Lung Cancer Cohort: Prognostic Biomarkers Improve Selection of Patients for Second-Line Treatment Open
Background: Small-cell lung cancer (SCLC) is a highly aggressive tumor, and overall survival (OS) remains poor despite intensive efforts to develop new treatment strategies. In second line, topotecan is the only approved drug, with a media…
View article: Infection and the microbiome in bronchiectasis
Infection and the microbiome in bronchiectasis Open
Bronchiectasis is marked by bronchial dilatation, recurrent infections and significant morbidity, underpinned by a complex interplay between microbial dysbiosis and immune dysregulation. The identification of distinct endophenotypes have r…
View article: Williams–Campbell syndrome case series and discordant twins
Williams–Campbell syndrome case series and discordant twins Open
Williams-Campbell syndrome (WCS) presents diagnostic challenges. This case series highlights clinical complexities and genetic/environmental interplay, and underscores the need for personalised treatment approaches. #WCS #RareDisease
View article: Primary Ciliary Dyskinesia in Adult Bronchiectasis
Primary Ciliary Dyskinesia in Adult Bronchiectasis Open
View article: Benralizumab Reduces Respiratory Exacerbations and Oral Glucocorticosteroid Dose in Patients with Severe Asthma and Eosinophilic Granulomatosis with Polyangiitis
Benralizumab Reduces Respiratory Exacerbations and Oral Glucocorticosteroid Dose in Patients with Severe Asthma and Eosinophilic Granulomatosis with Polyangiitis Open
In this real-life cohort of patients with severe asthma and EGPA, benralizumab initiation during remission maintenance reduced respiratory exacerbations and daily OCS dose. Benralizumab initiation during remission induction was associated …
View article: Effects of triple therapy on disease burden in patients of GOLD groups C and D: results from the observational COPD cohort COSYCONET
Effects of triple therapy on disease burden in patients of GOLD groups C and D: results from the observational COPD cohort COSYCONET Open
View article: Bronchiectasis and asthma: Data from the European Bronchiectasis Registry (EMBARC)
Bronchiectasis and asthma: Data from the European Bronchiectasis Registry (EMBARC) Open
View article: Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti- IL5 Treatments
Domestic Parasitic Infections in Patients with Asthma and Eosinophilia in Germany – Three Cases with Learnings in the Era of Anti- IL5 Treatments Open
Eosinophilic inflammation is a hallmark of asthma, and blood eosinophilia has been established as a biomarker for phenotyping asthma and predicting the response to anti-IL5 treatments. Although parasitic infections are rare in European adu…
View article: Tumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report
Tumor seeding following CT- guided transthoracic needle biopsy in lung cancer. A case report Open
View article: Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality
Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality Open
View article: P059 Therapeutic drug monitoring of elexacaftor/tezacaftor/ivacaftor over 1 year in adult patients with cystic fibrosis
P059 Therapeutic drug monitoring of elexacaftor/tezacaftor/ivacaftor over 1 year in adult patients with cystic fibrosis Open
View article: Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality
Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality Open
Background: Chest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim of this work was to evaluate the association of Pi10 as a measure of standardized airway wall thickness on CT wit…
View article: Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease Open
View article: Response to high-altitude triggers in seasonal asthmatics on and off inhaled corticosteroid treatment
Response to high-altitude triggers in seasonal asthmatics on and off inhaled corticosteroid treatment Open
View article: Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS
Psychometric Validation of the German Translation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B)—Data from the German Bronchiectasis Registry PROGNOSIS Open
Patients with bronchiectasis feature considerable symptom burden and reduced health-related quality of life (QOL). We provide the psychometric validation of the German translation of the disease-specific Quality of Life Questionnaire-Bronc…
View article: Changes in Behavior After Vaccination and Opinions Toward Mask Wearing: Thoracic Oncology Patient–Reported Experiences During the COVID-19 Pandemic
Changes in Behavior After Vaccination and Opinions Toward Mask Wearing: Thoracic Oncology Patient–Reported Experiences During the COVID-19 Pandemic Open
Background: The COVID-19 vaccines, face masks, and social distancing are effective interventions to prevent SARS-CoV-2 infections. In this study, we aimed to determine lung cancer patients’ attitudes toward vaccination, changes in behavior…
View article: Pulmonary function impairment of asymptomatic and persistently symptomatic patients 4 months after COVID-19 according to disease severity
Pulmonary function impairment of asymptomatic and persistently symptomatic patients 4 months after COVID-19 according to disease severity Open
View article: Randomization of Left-Right Asymmetry and Congenital Heart Defects
Randomization of Left-Right Asymmetry and Congenital Heart Defects Open
Background: Nearly one in 100 live births presents with congenital heart defects (CHD). CHD is frequently associated with laterality defects, such as situs inversus , a mirrored positioning of internal organs. Body laterality is establishe…
View article: Intersectoral Cost of Treating Pulmonary Non-Tuberculosis Mycobacterial Disease (NTM-PD) in Germany—A Change of Perspective in Disease Management
Intersectoral Cost of Treating Pulmonary Non-Tuberculosis Mycobacterial Disease (NTM-PD) in Germany—A Change of Perspective in Disease Management Open
Background: In line with its increasing prevalence, pulmonary Mycobacterium avium complex (MAC) disease (MAC-PD) gives rise to substantial healthcare costs. However, there is only limited information on the costs of intersectoral reimburse…
View article: P1.01-17 Changes in Pulmonary Function During Platinum-Doublet Chemotherapy for Lung Cancer
P1.01-17 Changes in Pulmonary Function During Platinum-Doublet Chemotherapy for Lung Cancer Open
View article: Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography
Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography Open
Chronic hypoxia causes pulmonary vascular remodeling resulting in persistently increased pulmonary arterial pressures (PAP) even after return to normoxia. Recently, interest in chronic intermittent hypobaric hypoxia (CIHH) was raised becau…
View article: Perception of climate change in patients with chronic lung disease
Perception of climate change in patients with chronic lung disease Open
Overall patients are more sensitive to health-related consequences of climate change. Yet, the hazard of heat-days seems underestimated and awareness should be raised.