Pooja Mandke
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View article: Aging Increases Short, Inverted Repeat‐Mediated Genomic Instability In Vivo
Aging Increases Short, Inverted Repeat‐Mediated Genomic Instability In Vivo Open
Genomic instability is a hallmark of aging and cancer. A key contributor to genomic instability includes alternative DNA structures, such as cruciform‐forming inverted repeats (IRs). Short IRs (< 100 bps) are abundant in the human genome, …
View article: Exploring the Roles of Different DNA Repair Proteins in Short Inverted Repeat Mediated Genomic Instability: A Pilot Study
Exploring the Roles of Different DNA Repair Proteins in Short Inverted Repeat Mediated Genomic Instability: A Pilot Study Open
Repetitive DNA sequences are abundant in the human genome and can adopt alternative (i.e., non-B) DNA structures. These sequences contribute to diverse biological functions, including genomic instability. Previously, we found that Z-DNA-, …
View article: Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation
Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation Open
Acute respiratory distress syndrome (ARDS) is a common and often fatal inflammatory lung condition without effective targeted therapies. Regulatory T cells (Tregs) resolve lung inflammation, but mechanisms that enhance Tregs to promote res…
View article: Interactive youth science workshops benefit student participants and graduate student mentors
Interactive youth science workshops benefit student participants and graduate student mentors Open
Science communication and outreach are essential for training the next generation of scientists and raising public awareness for science. Providing effective science, technology, engineering, and mathematics (STEM) educational outreach to …
View article: Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: Implications in DNA repair and immune responses
Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: Implications in DNA repair and immune responses Open
High mobility group box protein 1 (HMGB1) is a highly versatile, abundant, and ubiquitously expressed, non-histone chromosomal protein, which belongs to the HMGB family of proteins. These proteins form an integral part of the architectural…
View article: Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension
Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension Open
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Cigarette smoke (CS) drives disease development and progression. The epithelial barrier is damaged by CS with increased monolayer permeability. Howev…
View article: Correction: Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
Correction: Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation Open
Aggarwal, N. R., K. Tsushima, Y. Eto, A. Tripathi, P. Mandke, J. R. Mock, B. T. Garibaldi, B. D. Singer, V. K. Sidhaye, M. R. Horton, L. S. King, and F. R. D’Alessio. 2014. Immunological priming requires regulatory T cells and IL-10–produc…
View article: Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming
Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming Open
Despite intense investigation, acute respiratory distress syndrome (ARDS) remains an enormous clinical problem for which no specific therapies currently exist. In this study, we used intratracheal lipopolysaccharide or Pseudomonas bacteria…
View article: Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells
Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells Open
Flow cytometry is a powerful tool capable of simultaneously analyzing multiple parameters on a cell-by-cell basis. Lung tissue preparation for flow cytometry requires creation of a single-cell suspension, which often employs enzymatic and …
View article: HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation
HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation Open
Several clinical studies show that individuals with HIV are at an increased risk for worsened lung function and for the development of COPD, although the mechanism underlying this increased susceptibility is poorly understood. The airway e…
View article: Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure
Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure Open
Background. Chronic obstructive pulmonary disease (COPD) is a common, smoking-related lung disease. Patients with COPD frequently suffer disease exacerbations induced by bacterial respiratory infections, suggestive of impaired innate immun…