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View article: Acquired amphotericin B resistance and fitness trade-off compensation in Candida auris
Acquired amphotericin B resistance and fitness trade-off compensation in Candida auris Open
Candida auris is an emergent human fungal pathogen of growing concern due to common drug resistance to all major antifungal drug classes. Although resistance to amphotericin B (AMB) has been detected in 30 to 60% of clinical isolates of C.…
View article: 623. Advancing Fungal Diagnostics with a Transcriptional Approach
623. Advancing Fungal Diagnostics with a Transcriptional Approach Open
Background Invasive fungal infections are increasingly common and carry high rates of morbidity and mortality, and rising rates of drug resistance, notably in Candida auris. However, there is a notable gap between the development of bacter…
View article: Genetic diversity and microevolution in clinical <i>Cryptococcus</i> isolates from Cameroon
Genetic diversity and microevolution in clinical <i>Cryptococcus</i> isolates from Cameroon Open
Cryptococcal meningitis is the second most common cause of death in people living with HIV/AIDS, yet we have a limited understanding of how cryptococcal isolates change over the course of infection. Cryptococcal infections are environmenta…
View article: Impact of pathogen genetics on clinical phenotypes in a population of <i>Talaromyces marneffei</i> from Vietnam
Impact of pathogen genetics on clinical phenotypes in a population of <i>Talaromyces marneffei</i> from Vietnam Open
Talaromycosis, a severe and invasive fungal infection caused by Talaromyces marneffei, is difficult to treat and impacts those living in endemic regions of Southeast Asia, India, and China. While 30% of infections result in mortality, our …
View article: Impact of pathogen genetics on clinical phenotypes in a population of<i>Talaromyces marneffei</i>from Vietnam
Impact of pathogen genetics on clinical phenotypes in a population of<i>Talaromyces marneffei</i>from Vietnam Open
Talaromycosis, a severe and invasive fungal infection caused by Talaromyces marneffei , is difficult to treat and impacts those living in endemic regions of southeast Asia, India, and China. While 30% of infections result in mortality, our…
View article: Similar evolutionary trajectories in an environmental <i>Cryptococcus neoformans</i> isolate after human and murine infection
Similar evolutionary trajectories in an environmental <i>Cryptococcus neoformans</i> isolate after human and murine infection Open
A pet cockatoo was the suspected source of Cryptococcus neoformans recovered from an immunocompromised patient with cryptococcosis based on molecular analyses available in 2000. Here, we report whole genome sequence analysis of the clinica…
View article: Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome
Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome Open
Infection outcomes for cryptococcosis, most commonly caused by C. neoformans , are influenced by host immune responses as well as by host and pathogen genetics. Infecting yeast isolates are genetically diverse; however, we lack a deep unde…
View article: S2.5d Exploring multidrug resistance, fitness compensation, and collateral sensitivity in <i>Candida auris</i> : Fight fire with fire?
S2.5d Exploring multidrug resistance, fitness compensation, and collateral sensitivity in <i>Candida auris</i> : Fight fire with fire? Open
S2.5 Rare yeasts, September 21, 2022, 3:00 PM - 4:30 PM Candida auris (C. auris) is a recently emerged human fungal pathogen of growing concern due to its ability to acquire extensive multidrug resistance (MDR) to all four antifungal drug …
View article: A novel rRNA hybridization-based approach to rapid, accurate <i>Candida</i> identification directly from blood culture
A novel rRNA hybridization-based approach to rapid, accurate <i>Candida</i> identification directly from blood culture Open
Invasive fungal infections are increasingly common and carry high morbidity and mortality, yet fungal diagnostics lag behind bacterial diagnostics in rapidly identifying the causal pathogen. We previously devised a fluorescent hybridizatio…
View article: A novel rRNA hybridization-based approach to rapid, accurate <i>Candida</i> identification directly from blood culture
A novel rRNA hybridization-based approach to rapid, accurate <i>Candida</i> identification directly from blood culture Open
Invasive fungal infections are increasingly common and carry high morbidity and mortality, yet fungal diagnostics lag behind bacterial diagnostics in rapidly identifying the causal pathogen. We previously devised a fluorescent hybridizatio…
View article: Human and murine <i>Cryptococcus neoformans</i> infection selects for common genomic changes in an environmental isolate
Human and murine <i>Cryptococcus neoformans</i> infection selects for common genomic changes in an environmental isolate Open
A pet cockatoo was the suspected source of Cryptococcus neoformans recovered from the cerebral spinal fluid (CSF) of an immunocompromised patient with cryptococcosis based on the molecular analyses available in 2000. Here we report whole g…
View article: A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence
A bacterial endosymbiont of the fungus Rhizopus microsporus drives phagocyte evasion and opportunistic virulence Open
View article: Genomic variation across a clinical <i>Cryptococcus</i> population linked to disease outcome
Genomic variation across a clinical <i>Cryptococcus</i> population linked to disease outcome Open
Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor patient outcomes, accounting for approximately 180,000 deaths each year. Patient outcomes may be impacted by the underlying genetics of the infecting iso…
View article: Rhizopus_delemar_V4_GFF
Rhizopus_delemar_V4_GFF Open
Rhizopus delemar re-annotation GFF
View article: Rhizopus_delemar_V4_AnnotationFiles
Rhizopus_delemar_V4_AnnotationFiles Open
Annotation files for Rhizopus delemar
View article: 738. A Novel Molecular Diagnostic Assay for Identification of Fungal Pathogens
738. A Novel Molecular Diagnostic Assay for Identification of Fungal Pathogens Open
Background A rapid and accurate diagnostic method for invasive fungal infections remains a critical clinical need. We recently reported a rapid molecular method for bacterial species identification directly from clinical samples that targe…
View article: Host environmental conditions induce small fungal cell size and alter population heterogeneity in <i>Cryptococcus neoformans</i>
Host environmental conditions induce small fungal cell size and alter population heterogeneity in <i>Cryptococcus neoformans</i> Open
Fungal morphology significantly impacts the host response. Filamentation and tissue penetration by Candida and Aspergillus species are essential for virulence, while growth as a yeast allows the thermal dimorphic fungi Coccidiodes, Histopl…
View article: Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity
Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity Open
Opportunistic infections by environmental fungi are a growing clinical problem, driven by an increasing population of people with immunocompromising conditions. Spores of the Mucorales order are ubiquitious in the environment but can also …
View article: Bacterial endosymbionts influence fungal transcriptional profiles with implications for host response in the human fungal pathogens<i>Rhizopus microsporus</i>and<i>Rhizopus delemar</i>
Bacterial endosymbionts influence fungal transcriptional profiles with implications for host response in the human fungal pathogens<i>Rhizopus microsporus</i>and<i>Rhizopus delemar</i> Open
Mucorales spores, the causative agents of mucormycosis, interact with the innate immune system to cause acute, chronic, or resolving infection. Understanding the factors that influence disease initiation and progression is key to understan…
View article: Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen <i>Rhizopus delemar</i>
Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen <i>Rhizopus delemar</i> Open
Germination is key to the growth of many organisms, including fungal spores. Mucormycete spores exist abundantly within the environment and germinate to form hyphae. These spores are capable of infecting immunocompromised individuals, caus…
View article: Pathways of pathogenicity: The transcriptional stages of germination in the fatal fungal pathogen <i>Rhizopus delemar</i>
Pathways of pathogenicity: The transcriptional stages of germination in the fatal fungal pathogen <i>Rhizopus delemar</i> Open
Rhizopus delemar is an invasive fungal pathogen, responsible for the frequently fatal disease mucormycosis. Germination, a crucial mechanism by which spores of Rhizopus delemar infect and cause disease, is a key developmental process that …
View article: Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5
Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5 Open
ERK5 regulates nonlytic expulsion of live pathogens from phagocytes to limit dissemination of infections.