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View article: Author response: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
Author response: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 Open
View article: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a threat to public health. Current therapeutics remain limited to direct-acting antivirals that lack distinct mechanisms of action and are already showing signs…
View article: Author response: The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
Author response: The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2 Open
View article: The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2 Open
SARS-CoV-2 continues to pose a threat to public health. Current therapeutics remain limited to direct acting antivirals that lack distinct mechanisms of action and are already showing signs of viral resistance. The virus encodes an ADP-rib…
View article: The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a threat to public health. Current therapeutics remain limited to direct-acting antivirals that lack distinct mechanisms of action and are already showing signs…
View article: Identification of Transcriptional Regulators of Immune Evasion Across Cancers: An Alternative Immunotherapeutic Strategy for Cholangiocarcinoma
Identification of Transcriptional Regulators of Immune Evasion Across Cancers: An Alternative Immunotherapeutic Strategy for Cholangiocarcinoma Open
Background: Cancer immune evasion is a multifaceted process that synchronizes pro-tumoral immune infiltration, immunosuppressive inflammation, and inhibitory immune checkpoint expression (IC). Current immunotherapies combat this issue by r…
View article: Identification of Transcriptional Regulators of Immune Evasion across Cancers: An Alternative Immunotherapeutic Strategy for Cholangiocarcinoma
Identification of Transcriptional Regulators of Immune Evasion across Cancers: An Alternative Immunotherapeutic Strategy for Cholangiocarcinoma Open
Background: Immune evasion in cancer is a multifaceted process that synchronizes pro-tumoral immune infiltration, immunosuppressive inflammation, and inhibitory immune checkpoint expression (IC). Recent developments have immunotherapies su…
View article: Author Correction: Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial-to-mesenchymal transition of cholangiocarcinoma cells
Author Correction: Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial-to-mesenchymal transition of cholangiocarcinoma cells Open
View article: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Author response: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Author response: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
View article: Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Author Response: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Author Response: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Reviewer #1 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #1 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor Open
IFN-alpha have been reported to suppress hepatitis B virus (HBV) cccDNA via APOBEC3 cytidine deaminase activity through interferon signaling. To develop a novel anti-HBV drug for a functional cure, we performed in silico screening of the b…
View article: Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells
Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells Open
A poor outcome for cholangiocarcinoma (CCA) patients is still a clinical challenge. CCA is typically recognized by the desmoplastic nature, which accounts for its malignancy. Among various extracellular matrix proteins, laminin is the most…
View article: Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum
Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum Open
Voltage-sensing proteins generally consist of voltage-sensor domains and pore-gate domains, forming the voltage-gated ion channels. However, there are several unconventional voltage-sensor proteins that lack pore-gate domains, conferring t…
View article: Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria
Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria Open
View article: Simple But Efficacious Enrichment of Integral Membrane Proteins and Their Interactions for In-Depth Membrane Proteomics
Simple But Efficacious Enrichment of Integral Membrane Proteins and Their Interactions for In-Depth Membrane Proteomics Open
View article: Membrane proteome analysis for clarification of sex difference formation mechanism of pharmacokinetics in the kidney
Membrane proteome analysis for clarification of sex difference formation mechanism of pharmacokinetics in the kidney Open
The kidney are the major organs determining the drug elimination, and membrane transporters play a central role. There are reports that there are sex differences in the expression levels of transporters that are important in drug eliminati…
View article: Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses Open
Neurotransmission is based on the exocytic fusion of synaptic vesicles (SVs) followed by endocytic membrane retrieval and the reformation of SVs. Conflicting models have been proposed regarding the mechanisms of SV endocytosis, most notabl…
View article: Author response: Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Author response: Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurotransmission is b…
View article: Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses Open
Neurotransmission is based on the exocytic fusion of synaptic vesicles (SVs) followed by endocytic membrane retrieval and the reformation of SVs. Conflicting models have been proposed regarding the mechanisms of SV endocytosis, most notabl…
View article: Drug Discovery Targeting an Amino Acid Transporter for Diagnosis and Therapy
Drug Discovery Targeting an Amino Acid Transporter for Diagnosis and Therapy Open
Nutrients are essential for all living organisms. Because growing cancer cells have strong metabolic demands, nutrient transporters are constitutively increased to facilitate the nutrient uptake. Among these nutrient transporters, L-type a…
View article: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…