Pouria Akhbari
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View article: Impact of Bulky & Liposomal Secukinumab on Lymphocytes of Psoriatic Patients, to Determine the Improvement in Bioavailability of Secukinumab Nanolipo
Impact of Bulky & Liposomal Secukinumab on Lymphocytes of Psoriatic Patients, to Determine the Improvement in Bioavailability of Secukinumab Nanolipo Open
Psoriasis is an immune-mediated disease affecting the skin and joints. biologic treatments are often used in moderate to severe cases, administered as a monotherapy or in combination with other treatments. Liposomes are versatile and can e…
View article: Small things matter: Lack of extra-islet beta cells in Type 1 diabetes
Small things matter: Lack of extra-islet beta cells in Type 1 diabetes Open
Summary Recent 3D analyses reported abundant, small beta-cell-rich endocrine objects (EOs) in the human pancreas. Here, we assessed morphological parameters of >262,000 EOs in pancreas sections from 220 donors with or without type 1 diabet…
View article: <b>Soluble HLA class I is released from human β-cells following exposure to interferons</b>
<b>Soluble HLA class I is released from human β-cells following exposure to interferons</b> Open
HLA class I (HLA-I) molecules present intracellular antigenic peptides to CD8+ T lymphocytes during immune surveillance. In donors with type 1 diabetes, hyperexpression of HLA-I occurs in islets with residual insulin-producing β…
View article: Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes
Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes Open
View article: Soluble HLA Class I Is Released From Human β-Cells Following Exposure to Interferons
Soluble HLA Class I Is Released From Human β-Cells Following Exposure to Interferons Open
HLA class I (HLA-I) molecules present intracellular antigenic peptides to CD8+ T cells during immune surveillance. In donors with type 1 diabetes, hyperexpression of HLA-I occurs in islets with residual insulin-producing β-cells as a hallm…
View article: <b>Soluble HLA class I is released from human β-cells following exposure to interferons</b>
<b>Soluble HLA class I is released from human β-cells following exposure to interferons</b> Open
HLA class I (HLA-I) molecules present intracellular antigenic peptides to CD8+ T lymphocytes during immune surveillance. In donors with type 1 diabetes, hyperexpression of HLA-I occurs in islets with residual insulin-producing β…
View article: The Effects of Novel miRNAs Found in Exosome Vesicles Derived from Cord Blood Stem Cells (CBSCs-EVs) on CHL1 Melanoma Cells Compared to Healthy Control
The Effects of Novel miRNAs Found in Exosome Vesicles Derived from Cord Blood Stem Cells (CBSCs-EVs) on CHL1 Melanoma Cells Compared to Healthy Control Open
This study aimed to investigate the potential of Cord Blood Stem Cell-derived exosome vesicles (CBSC-EVs) in regulating cancer growth and preventing cellular damage. The study aimed to examine the effects of CBSC-EVs on CHL1 cancer cells a…
View article: Investigating the Impact of Secukinumab Bulk and Liposome Forms on Lymphocytes from Psoriasis Patients, as Compared to Healthy Controls, to Determine the Improvement in Bioavailability of Secukinumab Nanoliposomes
Investigating the Impact of Secukinumab Bulk and Liposome Forms on Lymphocytes from Psoriasis Patients, as Compared to Healthy Controls, to Determine the Improvement in Bioavailability of Secukinumab Nanoliposomes Open
Psoriasis is a multi-factorial immune-mediated disease that affects approximately 2% of the UK population and 2.5% worldwide. The condition can impact multiple organs, including the skin and joints. In moderate to severe cases, systemic an…
View article: Comparing P53 expression and genome-wide transcriptome profiling to Comet assay in lymphocytes from melanoma patients and healthy controls
Comparing P53 expression and genome-wide transcriptome profiling to Comet assay in lymphocytes from melanoma patients and healthy controls Open
View article: P53 expression, Genome-wide transcriptome profiling and LGS test (a blood test to detect cancer): comparison of UVA exposed lymphocytes from malignant melanoma patients and healthy controls.
P53 expression, Genome-wide transcriptome profiling and LGS test (a blood test to detect cancer): comparison of UVA exposed lymphocytes from malignant melanoma patients and healthy controls. Open
This study aimed to evaluate the expression of the P53 gene following exposure to varying doses of UVA radiation, using lymphocytes as surrogates. Lymphocytes from malignant melanoma (MM) patients (n = 20) with positive sentinel nodes were…
View article: Anticarcinogenic impact of extracellular vesicles (exosomes) from cord blood stem cells in malignant melanoma: A potential biological treatment
Anticarcinogenic impact of extracellular vesicles (exosomes) from cord blood stem cells in malignant melanoma: A potential biological treatment Open
Incidence of Malignant Melanoma has become the 5th in the UK. To date, the major anticancer therapeutics include cell therapy, immunotherapy, gene therapy and nanotechnology‐based strategies. Recently, extracellular vesicles, especially ex…
View article: Temporal regulation of interferon signalling in human EndoC-βH1 cells
Temporal regulation of interferon signalling in human EndoC-βH1 cells Open
During the development of type 1 diabetes, interferons (IFN) are elaborated from islet-infiltrating immune cells and/or from virally infected β-cells. They act via specific receptors to increase, acutely, the phosphorylation of the transcr…
View article: Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection
Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection Open
The generation of a human pancreatic beta cell line which reproduces the responses seen in primary beta cells, but is amenable to propagation in culture, has long been an important goal in diabetes research. This is particularly true for s…
View article: Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes
Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes Open
Interferon response sensors are expressed in the islet of Langerhans during the course of type 1 diabetes.
View article: Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection
Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection Open
Enteroviruses (EVs) have long been implicated in the pathogenesis of type 1 diabetes (T1D), and accumulating evidence has associated virus-induced autoimmunity with the loss of pancreatic beta cells in T1D. Inflammatory cytokines including…
View article: Studies of cell surface and soluble HLA class I expression in pancreatic beta cells exposed to interferons or Poly I:C
Studies of cell surface and soluble HLA class I expression in pancreatic beta cells exposed to interferons or Poly I:C Open
HLA class I (HLA-I) molecules play a crucial role in cell-mediated immunity by presenting peptide antigens to cytotoxic CD8+T cells. A pathological hallmark of Type 1 diabetes (T1D) is the hyperexpression of HLA-I in pancreatic islets that…
View article: PO-021 Merkel cell polyomavirus-encoded miRNA subverts the host cell immune response
PO-021 Merkel cell polyomavirus-encoded miRNA subverts the host cell immune response Open
Introduction Virus-encoded miRNAs are emerging as key regulators of persistent infection and host-cell immune evasion. Merkel cell polyomavirus (MCPyV), the predominant aetiological agent of the rare but deadly skin cancer, Merkel cell ca…
View article: MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis
MCV-miR-M1 Targets the Host-Cell Immune Response Resulting in the Attenuation of Neutrophil Chemotaxis Open