Po‐Yi Lee
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View article: Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia
Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia Open
Insufficient oxygenation in the lamina cribrosa (LC) may contribute to axonal damage and glaucomatous vision loss. To understand the range of susceptibilities to glaucoma, we aimed to identify key factors influencing LC oxygenation and exa…
View article: Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys
Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys Open
Purpose Our goal is to evaluate how lamina cribrosa (LC) oxygenation is affected by the tissue distortions resulting from elevated IOP. Design Experimental study on monkeys Subjects Four healthy monkey eyes with OCT scans with IOP of 10 to…
View article: The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure
The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure Open
LC blood flow was sensitive to distributed vessel collapses (stochastic and mixed) and moderately vulnerable to clustered collapses (systematic). Conversely, LC oxygenation was robust to distributed vessel collapses and sensitive to cluste…
View article: Insights into Hepatocellular Carcinoma in Patients with Thalassemia: From Pathophysiology to Novel Therapies
Insights into Hepatocellular Carcinoma in Patients with Thalassemia: From Pathophysiology to Novel Therapies Open
Thalassemia is a heterogeneous congenital hemoglobinopathy common in the Mediterranean region, Middle East, Indian subcontinent, and Southeast Asia with increasing incidence in Northern Europe and North America due to immigration. Iron ove…
View article: Direct measurements of collagen fiber recruitment in the posterior pole of the eye
Direct measurements of collagen fiber recruitment in the posterior pole of the eye Open
Collagen is the main load-bearing component of the peripapillary sclera (PPS) and lamina cribrosa (LC) in the eye. Whilst it has been shown that uncrimping and recruitment of the PPS and LC collagen fibers underlies the macro-scale nonline…
View article: Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues
Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues Open
View article: Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues
Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues Open
Collagen architecture determines the biomechanical environment in the eye, and thus characterizing collagen fiber organization and biomechanics is essential to fully understand eye physiology and pathology. We recently introduced instant p…
View article: Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles
Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles Open
Stretch-induced collagen uncrimping underlies the nonlinear mechanical behavior of the sclera according to what is often called the process of recruitment. We recently reported experimental measurements of sclera collagen crimp and pressur…
View article: Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa Open
View article: A Workflow for 3D Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network
A Workflow for 3D Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network Open
A comprehensive characterization of the 3D vascular network of the optic nerve head (ONH) is critical to understanding eye physiology and pathology. Current in vivo imaging technologies, however, do not have simultaneous high spatial resol…
View article: Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy Open
View article: Lamina cribrosa vessel and collagen beam networks are distinct
Lamina cribrosa vessel and collagen beam networks are distinct Open
View article: Lamina cribrosa vessel and collagen beam networks are distinct
Lamina cribrosa vessel and collagen beam networks are distinct Open
Our goal was to analyze the spatial interrelation between vascular and collagen networks in the lamina cribrosa (LC). Specifically, we quantified the percentages of collagen beams with/without vessels and of vessels inside/outside of colla…
View article: Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy Open
Current tools lack the temporal or spatial resolution necessary to image many important aspects of the architecture and dynamics of the optic nerve head (ONH). We evaluated the potential of instant polarized light microscopy (IPOL) to over…
View article: 3D eye-specific analysis of factors influencing lamina cribrosa oxygen concentration
3D eye-specific analysis of factors influencing lamina cribrosa oxygen concentration Open
View article: Real-time structured polarized light imaging (rtSPLI) for thick ocular tissue dynamics
Real-time structured polarized light imaging (rtSPLI) for thick ocular tissue dynamics Open
View article: Characterization of lamina cribrosa beam insertion into the sclera canal in sheep, pig, monkey, and human
Characterization of lamina cribrosa beam insertion into the sclera canal in sheep, pig, monkey, and human Open
View article: Microstructural evidence that lamina cribrosa beams (LC), peripapillary sclera (PPS) and central retinal artery (CRA) have distinct mechanical behaviors when stretched
Microstructural evidence that lamina cribrosa beams (LC), peripapillary sclera (PPS) and central retinal artery (CRA) have distinct mechanical behaviors when stretched Open
View article: Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution
Real-time measurement of lamina cribrosa and sclera collagen architecture and mechanics at sub-micron resolution Open
View article: Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics
Collagen fiber interweaving strongly influences sclera stiffness, and likely plays a central role in globe mechanics Open
View article: A vehicle with a two-wheel steering system mobile in shallow dense\n granular media
A vehicle with a two-wheel steering system mobile in shallow dense\n granular media Open
We design a vehicle with a steering system made of two independently\nrotatable wheels on the front. We quantify the effectiveness of the steering\nsystem in the mobility and maneuverability of the vehicle running in a box\ncontaining a la…
View article: A vehicle with a two-wheel steering system mobile in shallow dense granular media
A vehicle with a two-wheel steering system mobile in shallow dense granular media Open
We design a vehicle with a steering system made of two independently rotatable wheels on the front. We quantify the effectiveness of the steering system in the mobility and maneuverability of the vehicle running in a box containing a layer…
View article: Preliminary Biomechanical Study of Different Acetabular Reinforcement Devices for Acetabular Reconstruction
Preliminary Biomechanical Study of Different Acetabular Reinforcement Devices for Acetabular Reconstruction Open
Our study demonstrates the potential benefit of adding a locking mechanism to an ARD. Polyaxial ARDs provide the surgeon with more flexibility in placing the screws at the cost of reduced mechanical performance. This in vitro study provide…