Explanipedia

Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model Open

P.R. Poulsen, Line Kristensen, Valentin Vacari Møller, Jacob Johansen · 2025

Our findings suggest that oxygen availability is required for the normal tissue sparing associated with FLASH irradiation, and during hypoxia the FLASH DMF was reversed.

Determining the effects of hyperthermia on the tumor and acute normal tissue response of FLASH radiation Open

Priyanshu M. Sinha, Line Kristensen, Charlemagne Asonganyi Folefac, Lars Hjorth Præstegaard, Lone Hoffmann , et al. · 2025

Introduction: There is limited indication of how hyperthermia would influence the unique proposition of FLASH radiation – its ability to maintain comparable tumor response while offering protection to normal tissues. Hence, this study was …

Fractionation increasingly reduces FLASH sparing for acute murine skin damage Open

Line Kristensen, Sky Rohrer, Jacob Johansen, Lone Hoffmann, Lars Hjorth Præstegaard , et al. · 2025

Fractionation increasingly reduced the acute skin-sparing effect seen in single-fraction FLASH studies. However, a tissue-sparing effect of 18 % was still present at four fractions, while eight fractions provided a nonsignificant 5 % FLASH…

Which ‘dose rate’ definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin murine data Open

Isabella Colizzi, P.R. Poulsen, B. Sørensen, David Meer, Antony Lomax , et al. · 2025

We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for 'effective irradiation time…

Not all tumors are alike: varying efficacy of FLASH across tumor types and oxygenation status in spheroid models Open

Rebecka Dela, L. Silva, Sarah Beyer, Brita Singers Sørensen, P.R. Poulsen , et al. · 2025

Objectives Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models. Methods Spheroids from glioblastom…

Fixation method influences FLASH skin sparing in an in vivo leg model Open

Line Kristensen, Cathrine Overgaard, Jacob Johansen, Anna Mette Hansen, Niels Bassler , et al. · 2025

Background and purpose: The FLASH effect, where ultra-high dose rate elicits a favourable normal tissue-sparing, has been shown in several preclinical studies. Study setup differences, for example fixation methods that affect blood flow, c…

Cone-beam CT-based estimations of prostate motion and dose distortion during radiotherapy Open

Karolina A. Klucznik, T. Ravkilde, Simon Skouboe, Ditte Sloth Møller, Steffen Hokland , et al. · 2025

Real-Time Dose-Guided Radiation Therapy Open

Paul Keall, Issam El Naqa, Martin F. Fast, Emily A. Hewson, Nicholas Hindley , et al. · 2025

Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi Consensus Open

Yvonne L.B. Klaver, Mischa S. Hoogeman, Q. Richard Lu, Jeffrey D. Bradley, J. Isabelle Choi , et al. · 2025

Electron vs proton FLASH radiation on murine skin toxicity Open

Line Kristensen, Sky Rohrer, Lone Hoffmann, Lars Hjorth Præstegaard, C. Ankjærgaard , et al. · 2025

Despite apparent differences, e.g. average and instantaneous dose rates, the acute skin toxicity of electron beams and previously published proton beams were remarkably similar regarding both biological response and quantified acute skin D…

Fractionation Increasingly Reduces Flash Sparing for Acute Murine Skin Damage Open

Line Kristensen, Sky Rohrer, Jacob Johansen, Lone Hoffmann, Lars Hjorth Præstegaard , et al. · 2025

Which ‘Dose Rate’ Describes the Flash Sparing Effect? An Insight from Skin Murine Data Open

Isabella Colizzi, P.R. Poulsen, Brita Singers Sørensen, D. Meer, Antony Lomax , et al. · 2025

Which ‘Dose Rate’ Describes the Flash Sparing Effect? An Insight from Skin Murine Data Open

Isabella Colizzi, P.R. Poulsen, Brita Singers Sørensen, D. Meer, Antony Lomax , et al. · 2025

Impact of Oxygen Deprivation on the FLASH Effect for Skin Toxicity in a Murine model Open

Axel Kornerup Hansen, P.R. Poulsen, Line Kristensen, Valentin Vacari Møller, Priyanshu M. Sinha , et al. · 2025

The TROG 15.01 stereotactic prostate adaptive radiotherapy utilizing kilovoltage intrafraction monitoring (SPARK) clinical trial database Open

C. Sengupta, Doan Trang Nguyen, Yifan Li, Emily A. Hewson, Helen J. Ball , et al. · 2024

Purpose The US National Institutes of Health state that Sharing of clinical trial data has great potential to accelerate scientific progress and ultimately improve public health by generating better evidence on the safety and effectiveness…

Editorial: Harnessing the potential of FLASH: questions we must address prior to effective clinical translation Open

P.R. Poulsen, Kevin M. Prise, R. Mackay · 2024

Accuracy of four models and update strategies to estimate liver tumor motion from external respiratory motion Open

Payam Samadi Miandoab, E. Worm, Rune Hansen, Britta Weber, Morten Høyer , et al. · 2024

Background This study investigates different strategies for estimating internal liver tumor motion during radiotherapy based on continuous monitoring of external respiratory motion combined with sparse internal imaging. Methods Fifteen pat…

Motion-induced dose perturbations in photon radiotherapy and proton therapy measured by deformable liver-shaped 3D dosimeters in an anthropomorphic phantom Open

Simon H. Vindbæk, Stefanie Ehrbar, E. Worm, L.P. Muren, Stephanie Tanadini‐Lang , et al. · 2024

Proton FLASH: Impact of Dose Rate and Split Dose on Acute Skin Toxicity in a Murine Model Open

Brita Singers Sørensen, Eleni Kanouta, C. Ankjærgaard, Line Kristensen, Jacob Johansen , et al. · 2024

Evaluation of in vitro irradiation setup: Designed for the horizontal beamline at the Danish Centre for Particle Therapy Open

Anders Tobias Frederiksen, Morten B. Jensen, P.R. Poulsen, Niels Bassler, Brita Singers Sørensen , et al. · 2024

Background: Radiobiological experimental setups are challenged by precise sample positioning along depth dose profile, scattering conditions, and practical difficulties that must be addressed in individual designs. The aim of this study wa…

Multi‐institutional consensus on machine QA for isochronous cyclotron‐based systems delivering ultra‐high dose rate (FLASH) pencil beam scanning proton therapy in transmission mode Open

Kees Spruijt, Sina Mossahebi, Haibo Lin, Eunsin Lee, J. K. Kraus , et al. · 2023

Background The first clinical trials to assess the feasibility of FLASH radiotherapy in humans have started (FAST‐01, FAST‐02) and more trials are foreseen. To increase comparability between trials it is important to assure treatment quali…

The first clinical implementation of real-time 6 degree-of-freedom image-guided radiotherapy for liver SABR patients Open

C. Sengupta, Doan Trang Nguyen, T. B. Moodie, Daniel Mason, Jianjie Luo , et al. · 2023

This work demonstrates that real-time 6DoF IGRT for liver can be implemented on standard radiotherapy systems to improve treatment accuracy and safety. The observations made during the treatments highlight the potential false assurance of …

Developing a 3D-printing-based method to create anthropomorphic dosimeters for radiotherapy-delivery verification Open

S. Jensen, Tobias B Erichsen, Margit Bak Jensen, E. Worm, P.R. Poulsen , et al. · 2023

Anthropomorphic three-dimensional (3D) dosimeters can be useful for verification of radiotherapy delivery. The aim of this study was to develop a 3D-printing-based method for creating anthropomorphic 3D dosimeters. Internal structures were…

Difference between planned and delivered radiotherapy dose to the internal mammary nodes in high-risk breast cancer patients Open

Anders W. Mølby Nielsen, Harald Spejlborg, Christina Maria Lutz, P.R. Poulsen, Birgitte Vrou Offersen · 2023

Surveying the clinical practice of treatment adaptation and motion management in particle therapy Open

Barbara Knäusl, Vicki Trier Taasti, P.R. Poulsen, L.P. Muren · 2023

Surveys on radiation oncology practice are like a snapshot of the real world, offering insights into the current state-of-the-art treatment planning and delivery while also highlighting the degree of clinical translation of research findin…

A simple method to measure the gating latencies in photon and proton based radiotherapy using a scintillating crystal Open

E. Worm, Jakob Borup Thomsen, Jacob Johansen, P.R. Poulsen · 2023

Background In respiratory gated radiotherapy, low latency between target motion into and out of the gating window and actual beam‐on and beam‐off is crucial for the treatment accuracy. However, there is presently a lack of guidelines and a…

Intrafraction tumor motion monitoring and dose reconstruction for liver pencil beam scanning proton therapy Open

Saber Nankali, E. Worm, Jakob Borup Thomsen, Line Bjerregaard Stick, Jenny Bertholet , et al. · 2023

Background Pencil beam scanning (PBS) proton therapy can provide highly conformal target dose distributions and healthy tissue sparing. However, proton therapy of hepatocellular carcinoma (HCC) is prone to dosimetrical uncertainties induce…

An experimental setup for proton irradiation of a murine leg model for radiobiological studies Open

Cathrine Bang Overgaard, Fardous Reaz, Mateusz Sitarz, P.R. Poulsen, Jens Overgaard , et al. · 2023

The purpose of this study was to introduce an experimental radiobiological setup used for in vivo irradiation of a mouse leg target in multiple positions along a proton beam path to investigate normal tissue- and tumor models with v…

3D range-modulators for proton therapy: near field simulations with FLUKA and comparison with film measurements Open

Warisara Charuchinda, Felix Horst, Yuri Simeonov, Christoph Schuy, Petar Penchev , et al. · 2023

The 3D range-modulator is a device used in particle delivery systems that can create a highly conformal and homogeneous dose distribution in the target volume with mono-energetic beams, providing an option for high dose-rate FLASH therapy.…

Time‐resolved dose rate measurements in pencil beam scanning proton FLASH therapy with a fiber‐coupled scintillator detector system Open

Eleni Kanouta, P.R. Poulsen, Gustavo Kertzscher, Mateusz Sitarz, Brita Singers Sørensen , et al. · 2022

Background The spatial and temporal dose rate distribution of pencil beam scanning (PBS) proton therapy is important in ultra‐high dose rate (UHDR) or FLASH irradiations. Validation of the temporal structure of the dose rate is crucial for…

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