Prabhas Chaudhari
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View article: Unconventional receptor functions and location-biased signaling of the lactate GPCR in the nucleus
Unconventional receptor functions and location-biased signaling of the lactate GPCR in the nucleus Open
G-protein-coupled receptors (GPCRs) are virtually involved in every physiological process. However, mechanisms for their ability to regulate a vast array of different processes remain elusive. An unconventional functional modality could at…
View article: Nuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes
Nuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes Open
The involvement of G-Protein-Coupled Receptors’ (GPCR) location bias in diverse cellular functions and their misregulation in pathology is an underexplored territory. HCAR1, a GPCR for lactate is linked to cancer progression, mainly due to…