Prabodh Risal
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View article: Prevalence of MTHFR C677T polymorphism and its association with serum homocysteine and blood pressure among different ethnic groups: insights from a cohort study of Nepal
Prevalence of MTHFR C677T polymorphism and its association with serum homocysteine and blood pressure among different ethnic groups: insights from a cohort study of Nepal Open
Background The risk of hypertension varies based on ethnicity, environmental factors, and genetic predispositions. Studies have reported a higher risk of cardiovascular diseases (CVD) and hypertension among the Newar ethnic groups in Nepal…
View article: Agreement of results between dry and wet chemistry system for common clinical chemistry parameters
Agreement of results between dry and wet chemistry system for common clinical chemistry parameters Open
Background: The advancement of analytical chemistry has led to the use of automated systems in clinical laboratories, including liquid-based wet chemistry and film-based dry chemistry systems. Reflectance spectrophotometry-based dry chemis…
View article: Synergistic Effects of Vitis vinifera L. and Centella asiatica against CCl4-Induced Liver Injury in Mice
Synergistic Effects of Vitis vinifera L. and Centella asiatica against CCl4-Induced Liver Injury in Mice Open
Liver injury can be acute or chronic, resulting from a variety of factors, including viral hepatitis, drug overdose, idiosyncratic drug reaction, or toxins, while the progression of pathogenesis in the liver rises due to the involvement of…
View article: Attitude of Medical Students towards Biochemistry and Its Integration through Problem-Based Learning
Attitude of Medical Students towards Biochemistry and Its Integration through Problem-Based Learning Open
Introduction: Biochemistry is an important but volatile subject for undergraduate medical students and is included in integrated organ-based system with problem-based learning method in the curriculum of Kathmandu University School of Medi…
View article: Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients
Association between Serum Uric Acid and Blood Glucose Level in Diabetic and Non-diabetic Patients Open
Uric acid increases insulin resistance; likewise, hyperinsulinemia increases uric acid concentration, and both are global health problems. This study is conducted to find the association between serum uric acid and blood glucose level. Thi…
View article: COMPARATIVE STUDY OF SERUM ELECTROLYTES IN PATIENTS HAVING THYROID DYSFUNCTIONS WITH THE EUTHYROIDS IN A TERTIARY HOSPITAL IN NEPAL
COMPARATIVE STUDY OF SERUM ELECTROLYTES IN PATIENTS HAVING THYROID DYSFUNCTIONS WITH THE EUTHYROIDS IN A TERTIARY HOSPITAL IN NEPAL Open
Background: Thyroid hormone influences almost all metabolisms in the body and maintains body homeostasis. Since electrolytes homeostasis is also maintained by the thyroid hormone, we conducted this study to access the level of serum electr…
View article: Hepatoprotective Effects of a Natural Flavanol 3,3′-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade
Hepatoprotective Effects of a Natural Flavanol 3,3′-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade Open
Hepatic fibrosis is a form of irregular wound-healing response with acute and chronic injury triggered by the deposition of excessive extracellular matrix. Epithelial–mesenchymal transition (EMT) is a dynamic process that plays a crucial r…
View article: C-reactive Protein to Albumin Ratio among Patients Admitted to Intensive Care Unit of a Tertiary Care Hospital: A Descriptive Crosssectional Study
C-reactive Protein to Albumin Ratio among Patients Admitted to Intensive Care Unit of a Tertiary Care Hospital: A Descriptive Crosssectional Study Open
Introduction: Sepsis is the most common cause of mortality among patients admitted to intensive care unit. There is emerging evidence on the role of C-reactive protein to albumin ratio (C-reactive protein/Albumin) in predicting outcomes in…
View article: Microalbuminuria as a Predictor of Pre-eclampsia in Pregnant Women Presenting in the Antenatal Clinic at Dhulikhel Hospital
Microalbuminuria as a Predictor of Pre-eclampsia in Pregnant Women Presenting in the Antenatal Clinic at Dhulikhel Hospital Open
Background Pre-eclampsia is described as a pregnancy-specific syndrome that can affect virtually every organ system. The appearance of proteinuria remains an important diagnostic criterion. Proteinuria is an objective marker and reflects s…
View article: Correlative Analysis of Atherogenic Dyslipidemia among the Patients with Non Alcoholic Fatty Liver Disease Visiting Tertiary Care Center
Correlative Analysis of Atherogenic Dyslipidemia among the Patients with Non Alcoholic Fatty Liver Disease Visiting Tertiary Care Center Open
Introduction: Non-alcoholic fatty liver disease (NAFLD) is one of the most prominent causes of chronic liver disease. It is known that dyslipidemia in NAFLD patients may have more severe atherogenic potential with high triglyceride and low…
View article: Insights into Cardiovascular Disease Risk Based on Platelet Indices and Lipid Ratios in Reference to Glycemic Control and Duration of Diabetes
Insights into Cardiovascular Disease Risk Based on Platelet Indices and Lipid Ratios in Reference to Glycemic Control and Duration of Diabetes Open
Background: Diabetic patients are at the risk of untimely atherosclerotic cardiovascular disease. The level of blood lipids, their ratios, glycosylated hemoglobin, and platelet indices are potential markers for the assessment of cardiovasc…
View article: Nepali Translation and Reliability Analysis of Quantitative Androgen Deficiency in the Aging Male Questionnaire
Nepali Translation and Reliability Analysis of Quantitative Androgen Deficiency in the Aging Male Questionnaire Open
Background Androgen deficiency is diagnosed on the basis of clinical symptoms and laboratory assessment of testosterone level. Different screening tools have been developed to evaluate the sign and symptoms.
Objective In this study, we ex…
View article: Thyroid screening in prediabetes: Does it have any role?
Thyroid screening in prediabetes: Does it have any role? Open
Background: Thyroid dysfunction and hyperglycemia are common metabolic problem. Unrecognized thyroid dysfunction may amplify existing cardiovascular disease risk in hyperglycemic subjects. Early recognition and management of thyroid dysfun…
View article: Comparison between direct assay and popular equations for Low Density Lipoprotein-cholesterol estimation in Nepalese Population
Comparison between direct assay and popular equations for Low Density Lipoprotein-cholesterol estimation in Nepalese Population Open
Background: The aim of this study was to compare LDL-C estimations using various equations with directly measured LDL-C and to find the most accurate and reliable equation for measuring serum LDL-C at different triglycerides level. Materia…
View article: Cholinesterase and Liver Enzymes in Patients with Organophosphate Poisoning
Cholinesterase and Liver Enzymes in Patients with Organophosphate Poisoning Open
Background: Organ phosphorus compounds are one of the most common causes of insecticide poisoning worldwide leading to high degree of morbidity and mortality especially in the developing countries like Nepal. The liver is the main organ th…
View article: Factors Affecting Turnaround Time in the Clinical Laboratory of the Kathmandu University Hospital, Nepal.
Factors Affecting Turnaround Time in the Clinical Laboratory of the Kathmandu University Hospital, Nepal. Open
The major reasons of delayed laboratory reports were due to time consumed to fix the pre-analytical errors created by other departments rather than laboratory itself. Cash unit alone has the highest degree of error in total testing process…
View article: Prevalence and Factors Associated with Microalbuminuria among Type 2 Diabetic Patients : A Hospital Based Study
Prevalence and Factors Associated with Microalbuminuria among Type 2 Diabetic Patients : A Hospital Based Study Open
Introduction: Microalbuminuria is the earliest clinical evidence of diabetic nephropathy. However, prevalence and associated factors with microalbuminuria among type 2 diabetic patients has been understudied area of research in Nepalese co…
View article: Hypovitaminosis D in Healthy Health Care Professionals: A Real Deficiency or Necessity of New Reference Value for Specific Population?
Hypovitaminosis D in Healthy Health Care Professionals: A Real Deficiency or Necessity of New Reference Value for Specific Population? Open
Introduction:
Vitamin D, a steroid vitamin, has attracted noticeable interest of clinicians and researchers for decades because of its diverse array of biological functions. Various studies have shown that the level of vitamin D is low in…
View article: Infertility: An Emerging Public Health Issue in Nepal
Infertility: An Emerging Public Health Issue in Nepal Open
Infertility is one of the major health care problems worldwide, including Nepal. An increasing trend of infertility has been noticed recently in Nepal however, exact prevalence rate is still unknown. Male and female factors, lifestyle fact…
View article: Boost Up Quality Assurance through Regular Evaluation of Proficiency Testing Performance
Boost Up Quality Assurance through Regular Evaluation of Proficiency Testing Performance Open
Background: Participation in External Quality Assessment (EQA) program with practice of Internal Quality Control (IQC) is the excellent indicator of good laboratory practice (GLP) to assure quality services. EQA is an essential component o…
View article: Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy
Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy Open
Background: Chemotherapy agents alter serum lipids and C-peptide in cancer patients increased incidence of cardiovascular disorders and diabetes, although mechanisms for these are not known. Diabetes and cardiovascular riskis the highly co…