Pradeep Kumar Dabla
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View article: Clinical assessment and acceptance criteria for continuous glucose monitoring (CGM) system performance: A proposed guideline by the IFCC Working Group on CGM
Clinical assessment and acceptance criteria for continuous glucose monitoring (CGM) system performance: A proposed guideline by the IFCC Working Group on CGM Open
Continuous glucose monitoring (CGM) systems are essential tools for modern diabetes care. However, the assessment of their analytical performance has been hindered by a lack of standardization. This poses challenges for the field, as the c…
View article: Polymorphic variants in GABA-A receptor and their association with epilepsy and drug resistance: A North Indian cohort study
Polymorphic variants in GABA-A receptor and their association with epilepsy and drug resistance: A North Indian cohort study Open
BACKGROUND Gamma-aminobutyric acid type A receptor has long been acknowledged as a key target in the pathophysiology of epilepsy. The GABRA1 and GABRG2 genes encode the α1 and γ2 subunits of the gamma-aminobutyric acid type A receptor, a k…
View article: Risk Assessment Analysis of Type II Diabetes Mellitus and Dyslipidemia with Coronary Artery Stenosis Scoring: Intervention Strategies.
Risk Assessment Analysis of Type II Diabetes Mellitus and Dyslipidemia with Coronary Artery Stenosis Scoring: Intervention Strategies. Open
Our results suggest that lipoproteins and diabetic indicators have a considerable impact on the severity of CAD. This highlights the need for a more personalized approach in managing diabetes and CAD, incorporating regular monitoring of gl…
View article: Anti-epileptic medication induced disturbed calcium-vitamin D metabolism: A behavioral analysis using association rule mining technique
Anti-epileptic medication induced disturbed calcium-vitamin D metabolism: A behavioral analysis using association rule mining technique Open
BACKGROUND There is a lack of study on vitamin D and calcium levels in epileptic patients receiving therapy, despite the growing recognition of the importance of bone health in individuals with epilepsy. Associations one statistical method…
View article: Improving Laboratory Diagnosis of Creutzfeldt-Jakob Disease.
Improving Laboratory Diagnosis of Creutzfeldt-Jakob Disease. Open
Definitive diagnosis of CJD was possible with the help of various lab tests which helped rule out differential neurodegenerative diseases.
View article: Transformative impact of point-of-care testing in critical care
Transformative impact of point-of-care testing in critical care Open
The advent of point-of-care testing (POCT) has revolutionized the approach to patient management, especially for pediatric care. POCT provides rapid, on-the-spot biochemical and microbiological evaluations, bypassing delays typically assoc…
View article: Sodium channel mutation <i>SCN1A</i> T875M, D188V and associated dysfunction with drug resistant epilepsy
Sodium channel mutation <i>SCN1A</i> T875M, D188V and associated dysfunction with drug resistant epilepsy Open
BACKGROUND The NaV1.1 sodium channel alpha subunit, encoded by SCN1A , is crucial for initiating and propagating action potentials in neurons. SCN1A gene has long been an established target in the etiology and therapy of epilepsy. However,…
View article: Molecular Characterization and Impact of the Genetic Variants <i>GSTP1</i>, LncRNA <i>H19</i>, <i>TCF7L2</i> and <i>HNF1A</i> on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study
Molecular Characterization and Impact of the Genetic Variants <i>GSTP1</i>, LncRNA <i>H19</i>, <i>TCF7L2</i> and <i>HNF1A</i> on the Risk of Coronary Artery Disease With and Without T2DM Comorbidity: A Genomic Biomarker Study Open
The data from the current study have identified certain genetic variants of interest in the given population as risk markers of CAD with and without T2DM comorbidity.
View article: The Interplay Between High Cumulative Doses of Radioactive Iodine and Type 2 Diabetes Mellitus: A Complex Cardiovascular Challenge
The Interplay Between High Cumulative Doses of Radioactive Iodine and Type 2 Diabetes Mellitus: A Complex Cardiovascular Challenge Open
Starting from the metabolic profile of type 2 diabetes mellitus (T2DM), we hypothesized that the mechanisms of ¹³¹I-induced cardiotoxicity differ between patients diagnosed with differentiated thyroid cancer (DTC) with/without T2DM, with m…
View article: Integrating Patient-Generated Health Data from Mobile Devices into Electronic Health Records: Best Practice Recommendations by the IFCC Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MHBLM).
Integrating Patient-Generated Health Data from Mobile Devices into Electronic Health Records: Best Practice Recommendations by the IFCC Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MHBLM). Open
Considerations for interface ease-of-use, display of patient data in the EHR/EMR, and needs-based training programs for healthcare staff to understand the critical requirements, proper use, and integration of mobile health devices with EHR…
View article: External quality assessment performance in ten countries: an IFCC global laboratory quality project
External quality assessment performance in ten countries: an IFCC global laboratory quality project Open
Objectives This study aimed to assess the validity of external quality assessment (EQA) laboratory results across various cultural and environmental contexts and to identify potential improvement areas. Methods The International Federation…
View article: <i>SCN1A</i> rs6732655A/T polymorphism: Diagnostic and therapeutic insights for drug-resistant epilepsy
<i>SCN1A</i> rs6732655A/T polymorphism: Diagnostic and therapeutic insights for drug-resistant epilepsy Open
BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs, resulting in heightened mortality rates, psychosocial challenges, and a diminished quality of life. Genetic factors, …
View article: Exploring Natural Products to Control Type 2 Diabetes Mellitus through Targeting Advanced Glycation End Products
Exploring Natural Products to Control Type 2 Diabetes Mellitus through Targeting Advanced Glycation End Products Open
Objective: Cardiovascular disease (CVD) and diabetes mellitus (DM) are the pressing global health issue, with advanced glycation end products (AGEs) playing a crucial role in its development. AGEs are harmful compounds formed through chron…
View article: Role of lymphocyte-to-monocyte ratio as a predictive marker for diabetic coronary artery disease: A cross-sectional study
Role of lymphocyte-to-monocyte ratio as a predictive marker for diabetic coronary artery disease: A cross-sectional study Open
BACKGROUND The lymphocyte to monocyte ratio (LMR) is considered a marker of systemic inflammation in cardiovascular disease and acts as predictor of mortality in coronary artery disease. AIM To investigate the predictive role of LMR in dia…
View article: Discovering hidden patterns: Association rules for cardiovascular diseases in type 2 diabetes mellitus
Discovering hidden patterns: Association rules for cardiovascular diseases in type 2 diabetes mellitus Open
BACKGROUND It is increasingly common to find patients affected by a combination of type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), and studies are able to correlate their relationships with available biological and clini…
View article: "Role of Lipid Management in Cardiovascular Risk Assessment and Improving Prognosis"
"Role of Lipid Management in Cardiovascular Risk Assessment and Improving Prognosis" Open
Cardiovascular diseases (CVDs) have surged globally, particularly among younger populations, resulting in acute presentations and untimely fatalities. India, notably, grapples with CVDs as a leading cause of mortality, striking individuals…
View article: Unlocking new potential of clinical diagnosis with artificial intelligence: Finding new patterns of clinical and lab data
Unlocking new potential of clinical diagnosis with artificial intelligence: Finding new patterns of clinical and lab data Open
Recent advancements in science and technology, coupled with the proliferation of data, have also urged laboratory medicine to integrate with the era of artificial intelligence (AI) and machine learning (ML). In the current practices of evi…
View article: Validation and verification framework and data integration of biosensors and <i>in vitro</i> diagnostic devices: a position statement of the IFCC Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MBHLM) and the IFCC Scientific Division
Validation and verification framework and data integration of biosensors and <i>in vitro</i> diagnostic devices: a position statement of the IFCC Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MBHLM) and the IFCC Scientific Division Open
Advances in technology have transformed healthcare and laboratory medicine. Biosensors have emerged as a promising technology in healthcare, providing a way to monitor human physiological parameters in a continuous, real-time, and non-intr…
View article: Cardiovascular Disease Epidemic in India and Triglyceride-Associated Residual Atherosclerotic Cardiovascular Disease Risk
Cardiovascular Disease Epidemic in India and Triglyceride-Associated Residual Atherosclerotic Cardiovascular Disease Risk Open
Cardiovascular disease (CVD) is the leading global cause of mortality, with a significant rise in low- and middle-income countries. India faces a substantial burden of CVD, with alarming prevalence rates and an increase in associated death…
View article: Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients
Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients Open
BACKGROUND Coronary artery disease (CAD) is a major cause of death worldwide, and India contributes to about one-fifth of total CAD deaths. The development of CAD has been linked to the accumulation of Nε-carboxymethyl-lysine (CML) in hear…
View article: Review of: "[Commentary] Artificial Intelligence, or Artifact Intelligence? Most AI Is Not Ready for Practice"
Review of: "[Commentary] Artificial Intelligence, or Artifact Intelligence? Most AI Is Not Ready for Practice" Open
Potential competing interests: No potential competing interests to declare.Good article with newer insights and interest to the readers.To date, AI based techniques are helping epidemiologists and health workers in projecting the spread of…
View article: Urinary Biomarkers NGAL and Beta-2 Microglobulin for Detection of Diabetic Nephropathy in Type 1 Diabetes Mellitus
Urinary Biomarkers NGAL and Beta-2 Microglobulin for Detection of Diabetic Nephropathy in Type 1 Diabetes Mellitus Open
Objectives: Urinary neutrophil gelatinase-associated lipocalin (NGAL) and beta-2 microglobulin(β2M) have been evaluated as markers of tubular damage in type 2 diabetes mellitus. There is limited data on their performance to screen nephropa…
View article: Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study
Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study Open
Aim: Cardiovascular diseases (CVD) are the leading cause of death globally. In the condition of type 2 diabetes mellitus (T2DM), the prevalence of CVD increase parallel with the rise of metabolic complication and higher incidence of corona…
View article: Quality standards and internal quality control practices in medical laboratories: an IFCC global survey of member societies
Quality standards and internal quality control practices in medical laboratories: an IFCC global survey of member societies Open
Objectives The trueness and precision of clinical laboratory results are ensured through total quality management systems (TQM), which primarily include internal quality control (IQC) practices. However, quality practices vary globally. To…
View article: Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus: A narrative review of randomized control trials
Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus: A narrative review of randomized control trials Open
Antioxidant supplements can be a beneficial approach for the treatment of T2DM.
View article: A new door to a different world: opportunities from the metaverse and the raise of meta-medical laboratories
A new door to a different world: opportunities from the metaverse and the raise of meta-medical laboratories Open
Objectives In the digital age, the metaverse has emerged with impressive potential for many segments of society. The metaverse could be presented as a parallel dimension able to enhance the physical world as well as our actions and decisio…
View article: External quality assessment practices in medical laboratories: an IFCC global survey of member societies
External quality assessment practices in medical laboratories: an IFCC global survey of member societies Open
Objectives Clinical laboratory results are required for critical medical decisions, underscoring the importance of quality results. As part of total quality management, external quality assessment (EQA) is a vital component to ensure labor…
View article: Pharmacogenetics of CYP2C19*17: Functional and Clinical Implications of CYP2C19*17 - rs12248560 (c.-806C>T) in the Development of Type 2 Diabetes
Pharmacogenetics of CYP2C19*17: Functional and Clinical Implications of CYP2C19*17 - rs12248560 (c.-806C>T) in the Development of Type 2 Diabetes Open
The prevalence of diabetes mellitus (DM) is increasing worldwide including Saudi Arabia. DM increases mortality rate, morbidity and vascular complications, accompanied by poor general health status and low quality of life. CYP2C19*17 polym…
View article: Target association rule mining to explore novel paediatric illness patterns in emergency settings
Target association rule mining to explore novel paediatric illness patterns in emergency settings Open
ARM is an effective data analysis technique to find meaningful patterns using clinical features with actual numbers in pediatric critical illness. It can prove to be important while analysing the association of clinical attributes with dis…
View article: Discovering Patterns of Cardiovascular Disease and Diabetes in Myocardial Infarction Patients Using Association Rule Mining
Discovering Patterns of Cardiovascular Disease and Diabetes in Myocardial Infarction Patients Using Association Rule Mining Open
Highlights: Association Rule Mining tools predict the association of early-onset Myocardial Infarction with Hypertension and Diabetes Mellitus. Association Rule Mining tools using clinical and biochemical attributes can predict the develop…