Pradeep M. Joshi
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View article: Multimodal sensory inputs and mechanosensory components mediate C. elegans negative gravitaxis
Multimodal sensory inputs and mechanosensory components mediate C. elegans negative gravitaxis Open
Summary: The ability to sense Earth’s gravitational pull is essential for orientation, navigation, and proprioception in most organisms. We report here that C. elegans dauer larvae and adults show a pronounced tendency to move upward away …
View article: Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways
Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways Open
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed ce…
View article: Endless Worms Most Beautiful: Current Methods For Using Nematodes To Study Evolutionary Developmental Biology
Endless Worms Most Beautiful: Current Methods For Using Nematodes To Study Evolutionary Developmental Biology Open
ARTICLES DISCUSSED: Tintori, S. C., Sloat, S. A., Rockman, M. V. Rapid isolation of wild nematodes by baermann funnel. Journal of Visualized Experiments. (179) (2022). Crombie, T. A., Tanny, R. E., Buchanan, C. M., Roberto, N. M., Andersen…
View article: Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during <i>Caenorhabditis elegans</i> endoderm development
Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during <i>Caenorhabditis elegans</i> endoderm development Open
The architecture of gene regulatory networks determines the specificity and fidelity of developmental outcomes. We report that the core regulatory circuitry for endoderm development in Caenorhabditis elegans operates through a transcriptio…
View article: Mechanosensory Systems and Sensory Integration Mediate<i>C. elegans</i>Negative Gravitaxis
Mechanosensory Systems and Sensory Integration Mediate<i>C. elegans</i>Negative Gravitaxis Open
The ability to sense Earth’s gravitational pull is essential for orientation, navigation, and proprioception in many organisms. We report here that C. elegans exhibits pronounced negative gravitaxis, or movement away from the Earth’s cente…
View article: Regulation of defective mitochondrial DNA accumulation and transmission in <i>C. elegans</i> by the programmed cell death and aging pathways
Regulation of defective mitochondrial DNA accumulation and transmission in <i>C. elegans</i> by the programmed cell death and aging pathways Open
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). “Purifying selection” mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed ce…
View article: Albuterol extends lifespan of Caenorhabditis elegans
Albuterol extends lifespan of Caenorhabditis elegans Open
The objective of this experiment is to determine if the medication albuterol has a positive impact on the lifespan of C. elegans. We hypothesize that if albuterol is added to the diet of C. elegans, then the lifespan of C. elegans will inc…
View article: Early<i>C. elegans</i>embryos modulate cell division timing to compensate for, and survive, the discordant conditions of a severe temperature gradient
Early<i>C. elegans</i>embryos modulate cell division timing to compensate for, and survive, the discordant conditions of a severe temperature gradient Open
Despite a constant barrage of intrinsic and environmental noise, embryogenesis is remarkably reliable, suggesting the existence of systems that ensure faithful execution of this complex process. We report that early C. elegans embryos, whi…
View article: Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death
Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death Open
Timely sister chromatid separation, promoted by separase, is essential for faithful chromosome segregation. Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptotic enzymes known as caspases. We repo…
View article: An Autonomous Molecular Bioluminescent Reporter (AMBER) for voltage imaging in freely moving animals
An Autonomous Molecular Bioluminescent Reporter (AMBER) for voltage imaging in freely moving animals Open
1. Abstract Genetically encoded reporters have greatly increased our understanding of biology, especially in neuroscience. While fluorescent reporters have been widely used, photostability and phototoxicity have hindered their use in long-…
View article: Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network
Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network Open
Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, into the C. ele…
View article: Author response: Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network
Author response: Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Innovations in metazoan devel…
View article: Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death
Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death Open
Timely sister chromatid separation, promoted by separase, is essential for faithful chromosome segregation. Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptotic enzymes known as caspases. We repo…
View article: Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network
Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network Open
Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, into the C. ele…
View article: The multipotency‐to‐commitment transition in <i>Caenorhabditis elegans</i>—implications for reprogramming from cells to organs
The multipotency‐to‐commitment transition in <i>Caenorhabditis elegans</i>—implications for reprogramming from cells to organs Open
In animal embryos, cells transition from a multipotential state, with the capacity to adopt multiple fates, into an irreversible, committed state of differentiation. This multipotency‐to‐commitment transition ( MCT ) is evident from experi…
View article: Heterotaxy in<i>Caenorhabditis</i>: widespread natural variation in left–right arrangement of the major organs
Heterotaxy in<i>Caenorhabditis</i>: widespread natural variation in left–right arrangement of the major organs Open
Although the arrangement of internal organs in most metazoans is profoundly left–right (L/R) asymmetric with a predominant handedness, rare individuals show full (mirror-symmetric) or partial (heterotaxy) reversals. While the nematode Caen…
View article: Transorganogenesis and transdifferentiation in C. elegans are dependent on differentiated cell identity
Transorganogenesis and transdifferentiation in C. elegans are dependent on differentiated cell identity Open
The differentiated cell identities and structure of fully formed organs are generally stable after their development. In contrast, we report here that development of the C. elegans proximal somatic gonad (hermaphrodite uterus and spermathe…