Pradeep Reddy Cingaram
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View article: Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation Open
View article: Enhancing Transcriptome Mapping with Rapid PRO-seq Profiling of Nascent RNA
Enhancing Transcriptome Mapping with Rapid PRO-seq Profiling of Nascent RNA Open
Precision nuclear run-on (PRO) sequencing (PRO-seq) is a powerful technique for mapping polymerase active sites with nucleotide resolution and measuring newly synthesized transcripts at both promoters and enhancer elements. The current PRO…
View article: Epigenetic therapy: BBC1115, a novel BET inhibitor with broad antitumor activity
Epigenetic therapy: BBC1115, a novel BET inhibitor with broad antitumor activity Open
View article: CRISPR-Cas9 in hiPSCs: A new era in personalized treatment for Stargardt disease
CRISPR-Cas9 in hiPSCs: A new era in personalized treatment for Stargardt disease Open
Inherited retinal dystrophies, including Stargardt disease, are a group of genetic eye diseases that currently lack effective treatment options. The CRISPR-Cas9 gene editing system and human induced pluripotent stem cells (hiPSCs) offer a …
View article: The Integrator complex regulates microRNA abundance through RISC loading
The Integrator complex regulates microRNA abundance through RISC loading Open
MicroRNA (miRNA) homeostasis is crucial for the posttranscriptional regulation of their target genes during development and in disease states. miRNAs are derived from primary transcripts and are processed from a hairpin precursor intermedi…
View article: tRF-1001: A potential therapeutic target for ocular neovascular diseases
tRF-1001: A potential therapeutic target for ocular neovascular diseases Open
View article: Ferroptosis gene signature in cholangiocarcinoma
Ferroptosis gene signature in cholangiocarcinoma Open
Ferroptosis is a recently discovered iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Many studies suggest that ferroptosis plays a critical role in tumor suppression, opening up new avenues for c…
View article: The tRNA-derived fragment signature in lung cancer
The tRNA-derived fragment signature in lung cancer Open
A new class of regulatory small non-coding RNAs called tRNA-derived fragments (tRDFs) has distinct biological roles in various types of cancer. In this issue of Molecular Therapy – Oncolytics, Zitong Gao et al. performed a thorough study o…
View article: A potential therapeutic approach for tauopathies
A potential therapeutic approach for tauopathies Open
View article: Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin
Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin Open
The cellular prion protein (PrPC) is renowned for its infectious conformational isoform PrPSc, capable of templating subsequent conversions of healthy PrPCs and thus triggering the group of incurable diseases known as transmissible spongif…
View article: Integrator enforces the fidelity of transcriptional termination at protein-coding genes
Integrator enforces the fidelity of transcriptional termination at protein-coding genes Open
Integrator directly binds and terminates protein-coding transcripts enriched in alternative polyadenylation sequences.
View article: The Integrator complex regulates microRNA abundance through RISC loading
The Integrator complex regulates microRNA abundance through RISC loading Open
MicroRNA (miRNA) homeostasis is crucial for the post-transcriptional regulation of their target genes and miRNA dysregulation has been linked to multiple diseases, including cancer. The molecular mechanisms underlying miRNA biogenesis from…
View article: The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts Open
View article: Investigation of the role of prion protein in protection against transition metal induced toxicity
Investigation of the role of prion protein in protection against transition metal induced toxicity Open
View article: Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu2+, Mn2+, Zn2+ and Co2+ Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity
Prion Protein Does Not Confer Resistance to Hippocampus-Derived Zpl Cells against the Toxic Effects of Cu2+, Mn2+, Zn2+ and Co2+ Not Supporting a General Protective Role for PrP in Transition Metal Induced Toxicity Open
The interactions of transition metals with the prion protein (PrP) are well-documented and characterized, however, there is no consensus on their role in either the physiology of PrP or PrP-related neurodegenerative disorders. PrP has been…