Pradeep S. Rajendran
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View article: EEG Data Quality in Large-Scale Field Studies in India and Tanzania
EEG Data Quality in Large-Scale Field Studies in India and Tanzania Open
There is a growing imperative to understand the neurophysiological impact of our rapidly changing and diverse technological, social, chemical, and physical environments. To untangle the multidimensional and interacting effects requires dat…
View article: EEG data quality in large scale field studies in India and Tanzania
EEG data quality in large scale field studies in India and Tanzania Open
There is a growing imperative to understand the neurophysiological impact of our rapidly changing and diverse technological, social, chemical, and physical environments. To untangle the multidimensional and interacting effects requires dat…
View article: The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine
The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine Open
View article: CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization Open
Multilocular adipocytes are a hallmark of thermogenic adipose tissue1,2, but the factors that enforce this cellular phenotype are largely unknown. Here, we show that an adipocyte-selective product of the Clstn3 locus (CLSTN3β) p…
View article: A Peek Into the Future: Will Serial Multimarker Testing Help Bring a New Era of Precision Medicine in Heart Failure Patients?
A Peek Into the Future: Will Serial Multimarker Testing Help Bring a New Era of Precision Medicine in Heart Failure Patients? Open
View article: Decision letter: Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction
Decision letter: Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Sympathetic denervatio…
View article: Proarrhythmic Effects of Sympathetic Activation Are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts
Proarrhythmic Effects of Sympathetic Activation Are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts Open
View article: High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones
High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones Open
Remodeling of injured sympathetic nerves on the heart after myocardial infarction (MI) contributes to adverse outcomes such as sudden arrhythmic death, yet the underlying structural mechanisms are poorly understood. We sought to examine mi…
View article: Altered Sympathetic Control of Myocardial Infarct Border Zones: High-Resolution Mapping with Automated Structure Detection
Altered Sympathetic Control of Myocardial Infarct Border Zones: High-Resolution Mapping with Automated Structure Detection Open
Intramyocardial sympathetic nerve remodeling after myocardial infarction (MI) has been implicated in adverse outcomes such as sudden arrhythmic death, yet the underlying mechanisms are poorly understood. We sought to examine microstructura…
View article: Systemic AAV vectors for widespread and targeted gene delivery in rodents v2
Systemic AAV vectors for widespread and targeted gene delivery in rodents v2 Open
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel A…
View article: <scp>Lamina‐specific</scp> properties of spinal astrocytes
<span>Lamina‐specific</span> properties of spinal astrocytes Open
Astrocytes are indispensable for proper neuronal functioning. Given the diverse needs of neuronal circuits and the variety of tasks astrocytes perform, the perceived homogeneous nature of astrocytes has been questioned. In the spinal dorsa…
View article: Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas
Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas Open
Rationale: Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious resul…
View article: Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV
Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV Open
Vagus nerve stimulation has shown many benefits for disease therapies but current approaches involve imprecise electrical stimulation that gives rise to off-target effects, while the functionally relevant pathways remain poorly understood.…
View article: Pro-Arrhythmic Effects of Sympathetic Activation are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts
Pro-Arrhythmic Effects of Sympathetic Activation are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts Open
View article: Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas
Innervation and Neuronal Control of the Mammalian Sinoatrial Node: A Comprehensive Atlas Open
Cardiac function is under exquisite intrinsic cardiac neural control. Neuroablative techniques to modulate control of cardiac function are currently being studied in patients, albeit with variable and sometimes deleterious results. Recogni…
View article: Selective Modulation of Heart and Respiration by Optical Control of Vagus Nerve Axons Innervating the Heart
Selective Modulation of Heart and Respiration by Optical Control of Vagus Nerve Axons Innervating the Heart Open
Targeting specifics subsets of peripheral pathways of the autonomic nervous system will enable new avenues to study organ control and develop new disease therapies. Vagus nerve stimulation (VNS) has shown many therapeutic benefits but curr…
View article: Dual Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart during Optogenetic Stimulation of the ICNS v1
Dual Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart during Optogenetic Stimulation of the ICNS v1 Open
View article: Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction
Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction Open
Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following myocardial infarction (MI), but the critical neural pathways involved are not well understood. Cardiac adrenergic function is partly regulated by symp…
View article: Systemic AAV vectors for widespread and targeted gene delivery in rodents v1
Systemic AAV vectors for widespread and targeted gene delivery in rodents v1 Open
We recently developed adeno-associated virus (AAV) capsids to facilitate efficient and noninvasive gene transfer to the central and peripheral nervous systems. However, a detailed protocol for generating and systemically delivering novel A…
View article: Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation
Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation Open
Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-threatening cardiac arrhythmias. Because the underlying mechanisms and potential influence of diabetic autonomic neuropathy are not well understood, we ai…
View article: Neuromodulation for Ventricular Tachycardia and Atrial Fibrillation
Neuromodulation for Ventricular Tachycardia and Atrial Fibrillation Open
View article: Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents
Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents Open
View article: Issue Information
Issue Information Open
12 issues per year.Ins tu onal subscrip on prices for 2018 are: Print & Online: US$1738 (US), US$2702 (Rest of World), €1752 (Europe), £1382 (UK).Prices are exclusive of tax.Asia-Pacifi c GST, Canadian GST/HST and European VAT will be appl…
View article: Anesthetizing the Fibrillating Heart
Anesthetizing the Fibrillating Heart Open
See Article Lee et al
View article: Mouse Stellate Immunohistochemistry protocol v1
Mouse Stellate Immunohistochemistry protocol v1 Open
See mouse steallte isolation protocol 2 Complete/intact stellate ganglia are fixed in 4% paraformaldehyde overnight at 4 o C. 3Fixed tissue is rinsed in phosphate buffered saline (PBS), and stored in PBS + 0.02% sodium azide. 4The stellate…
View article: Pig- Heart Neuonal and Fiber Immunocytochemistry v1
Pig- Heart Neuonal and Fiber Immunocytochemistry v1 Open
View article: Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies Open
View article: Neuroinflammation as a mechanism for cardiovascular diseases
Neuroinflammation as a mechanism for cardiovascular diseases Open
View article: Transcardial perfusion of mouse v1
Transcardial perfusion of mouse v1 Open
View article: iDISCO clearing of mouse heart v1
iDISCO clearing of mouse heart v1 Open