Pradip Devhare
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View article: Evaluation and Immunogenicity of Combined Liposome-Based Vaccine Candidates against Hepatitis E and B Viruses in Rhesus Monkeys
Evaluation and Immunogenicity of Combined Liposome-Based Vaccine Candidates against Hepatitis E and B Viruses in Rhesus Monkeys Open
The administration of vaccines using a combination approach ensures better coverage and reduces the number of injections and cost. The present study assessed liposome-complexed DNA-corresponding proteins of hepatitis E and B viruses (HEV a…
View article: Addendum: Liquid biopsy and multi-analyte testing guided treatment of <i>HER2</i> positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy
Addendum: Liquid biopsy and multi-analyte testing guided treatment of <i>HER2</i> positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Open
View article: Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors
Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors Open
Hepatitis E virus (HEV) usually causes self-limiting acute hepatitis, but the disease can become chronic in immunocompromised individuals. HEV infection in pregnant women is reported to cause up to 30% mortality, especially in the third tr…
View article: Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors
Development and validation of a multigene variant profiling assay to guide targeted and immuno therapy selection in solid tumors Open
We present data on analytical validation of the multigene variant profiling assay (CellDx) to provide actionable indications for selection of targeted and immune checkpoint inhibitor (ICI) therapy in solid tumors. CellDx includes Next Gene…
View article: PR01.01 Evaluation of Circulating Tumor Cells for Non-Invasively Discerning Lung Primary from Metastasis
PR01.01 Evaluation of Circulating Tumor Cells for Non-Invasively Discerning Lung Primary from Metastasis Open
View article: Liquid biopsy and multi-analyte testing guided treatment of <i>HER2</i> positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy
Liquid biopsy and multi-analyte testing guided treatment of <i>HER2</i> positive periampullary adenocarcinoma with durable complete response after trastuzumab based therapy Open
Periampullary adenocarcinomas are rare neoplasm that originates from the pancreatic head, the ampulla of vater, the distal bile duct or the duodenum. Surgical resection followed by adjuvant therapy is considered as the standard of care tre…
View article: Management of a Refractory EIF3E-RSPO2 Fusion Positive Pilomatrical Cancer Patient with Encyclopedic Tumor Analysis Guided Treatment
Management of a Refractory EIF3E-RSPO2 Fusion Positive Pilomatrical Cancer Patient with Encyclopedic Tumor Analysis Guided Treatment Open
Pilomatrical carcinoma is an exceedingly rare, locally aggressive malignancy of the hair follicle.It may arise de novo as a solitary lesion or through malignant transformation from its pre-existing benign counterpart, pilomatrixoma.There a…
View article: Long Overall Survival in a Case of Refractory Stage IV Squamous Cell Carcinoma of Lung Treated with Personalized De Novo Combination Regimen
Long Overall Survival in a Case of Refractory Stage IV Squamous Cell Carcinoma of Lung Treated with Personalized De Novo Combination Regimen Open
View article: Circulating ensembles of tumor‐associated cells: A redoubtable new systemic hallmark of cancer
Circulating ensembles of tumor‐associated cells: A redoubtable new systemic hallmark of cancer Open
Circulating ensembles of tumor‐associated cells (C‐ETACs) which comprise tumor emboli, immune cells and fibroblasts pose well‐recognized risks of thrombosis and aggressive metastasis. However, the detection, prevalence and characterization…
View article: INNV-26. IN VITRO CHEMO RESISTANCE PROFILES OF CIRCULATING GLIAL CELLS REPLICATE CHEMO CHARACTERISTICS OF TUMOR TISSUE
INNV-26. IN VITRO CHEMO RESISTANCE PROFILES OF CIRCULATING GLIAL CELLS REPLICATE CHEMO CHARACTERISTICS OF TUMOR TISSUE Open
Survival of high-grade glioma patients remains dismal due to onset of resistance to even the limited systemic treatment option currently available. Except for indirect prediction of alkylating agent Temozolomide response through MGMT promo…
View article: PATH-64. PROSPECTIVE, BLINDED PLASMA BASED ANALYSIS FOR DIAGNOSIS OF NEWLY DIAGNOSED GLIOMA
PATH-64. PROSPECTIVE, BLINDED PLASMA BASED ANALYSIS FOR DIAGNOSIS OF NEWLY DIAGNOSED GLIOMA Open
INTRODUCTION In patients with newly diagnosed intracerebral lesions, gliomas are often suspected. However, other conditions such as multiple sclerosis, abscess or lymphoma are possible, as well. Furthermore, biopsy can be challenging due t…
View article: PATH-37. LIQUID BIOPSY FOR IDENTIFICATION OF NEWLY DIAGNOSED GLIOMA
PATH-37. LIQUID BIOPSY FOR IDENTIFICATION OF NEWLY DIAGNOSED GLIOMA Open
INTRODUCTION: In patients with newly diagnosed intracerebral lesions based on MRI, gliomas are often suspected, but MRI is rarely definitive thus necessitating biopsy. For non-enhancing lesions involving eloquent or deep-seated structures,…
View article: Association between MicroRNA-373 and Long Noncoding RNA NORAD in Hepatitis C Virus-Infected Hepatocytes Impairs Wee1 Expression for Growth Promotion
Association between MicroRNA-373 and Long Noncoding RNA NORAD in Hepatitis C Virus-Infected Hepatocytes Impairs Wee1 Expression for Growth Promotion Open
The mechanism of HCV-mediated liver pathogenesis is poorly understood. In this study, we observed that HCV infection upregulates miR-373 and Wee1, a pivotal player in the G 2 checkpoint in the cell cycle, although Wee1 is a direct target f…
View article: Encyclopedic Tumor Analysis for Treatment of Advanced, Broadly Refractory Cancers: Interim Results from the RESILIENT Trial
Encyclopedic Tumor Analysis for Treatment of Advanced, Broadly Refractory Cancers: Interim Results from the RESILIENT Trial Open
View article: Zika virus infection dysregulates human neural stem cell growth and inhibits differentiation into neuroprogenitor cells
Zika virus infection dysregulates human neural stem cell growth and inhibits differentiation into neuroprogenitor cells Open
View article: Hepatitis C virus–induced tumor‐initiating cancer stem–like cells activate stromal fibroblasts in a xenograft tumor model
Hepatitis C virus–induced tumor‐initiating cancer stem–like cells activate stromal fibroblasts in a xenograft tumor model Open
Hepatitis C virus (HCV) often causes persistent infection and is an increasingly important factor in the etiology of fibrosis/cirrhosis and hepatocellular carcinoma, although the mechanisms for the disease processes remain unclear. We have…
View article: Correction for Devhare et al., “Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells”
Correction for Devhare et al., “Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells” Open
View article: Hepatitis C virus–induced CCL5 secretion from macrophages activates hepatic stellate cells
Hepatitis C virus–induced CCL5 secretion from macrophages activates hepatic stellate cells Open
Hepatitis C virus (HCV)–mediated chronic liver disease is a serious health problem around the world and often causes fibrosis/cirrhosis and hepatocellular carcinoma. The mechanism of liver disease progression during HCV infection is still …
View article: Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells
Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells Open
Fibrogenic pathways in the liver are principally regulated by activation of hepatic stellate cells (HSC). Fibrosis is associated with chronic hepatitis C virus (HCV) infection, although the mechanism is poorly understood. HSC comprise the …
View article: A novel role of exosomes in the vaccination approach
A novel role of exosomes in the vaccination approach Open
Exosomes are the type of extracellular vesicles (EVs) derived from inward budding of the inner endosomal membrane to form multivesicular bodies, followed by the fusion of multivesicular bodies with the plasma membrane (1).
View article: Differential Expression of MicroRNAs in Hepatitis C Virus-Mediated Liver Disease Between African Americans and Caucasians: Implications for Racial Health Disparities
Differential Expression of MicroRNAs in Hepatitis C Virus-Mediated Liver Disease Between African Americans and Caucasians: Implications for Racial Health Disparities Open
African Americans (AAs) have higher hepatocellular carcinoma (HCC) mortality rates than Caucasian Americans (CAs). Chronic hepatitis C virus (HCV) infection leads to cirrhosis and HCC. HCV infection is highly prevalent in the AA population…
View article: Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies
Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies Open
View article: Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway
Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway Open
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in humans. We showed previously that HCV induces autophagy for viral persistence by preventing the innate immune response. Knockdo…
View article: GENO-01MOLECULAR INTERROGATION OF GLIOBLASTOMA MULTIFORME TUMORS IDENTIFIES A COMPLEX NETWORK OF CELL SIGNALLING PATHWAYS WITH POSSIBLE THERAPEUTIC IMPLICATIONS
GENO-01MOLECULAR INTERROGATION OF GLIOBLASTOMA MULTIFORME TUMORS IDENTIFIES A COMPLEX NETWORK OF CELL SIGNALLING PATHWAYS WITH POSSIBLE THERAPEUTIC IMPLICATIONS Open
The precise molecular mechanism behind Glioblastoma Grade IV with extremely poor treatment outcome for patients with even intensive therapy regimen is yet to be completely understood. GBMs represent approximately 17% of all primary brain t…