Pradyot Dash
YOU?
Author Swipe
View article: Safety, efficacy and total cost of point-of-care manufactured anti-CD19 CAR-T cell therapy in India: VELCART trial
Safety, efficacy and total cost of point-of-care manufactured anti-CD19 CAR-T cell therapy in India: VELCART trial Open
Decentralized or point-of-care (POC) manufacture of CAR-T cells is a potential strategy to improve accessibility and reduce cost and logistic challenges. A total of 10 relapsed/refractory patients (B cell acute lymphoblastic leukemia [B-AL…
View article: Spatial Tissue Analysis of Secondary Sarcoma Following CAR T Cell Therapy for B Cell Lymphoma
Spatial Tissue Analysis of Secondary Sarcoma Following CAR T Cell Therapy for B Cell Lymphoma Open
Introduction The appearance of secondary malignancies in patients receiving CAR T cell therapies has recently prompted regulatory scrutiny. Whereas the apparent frequency of such events is deemed low, and their risk is greatly outweighed b…
View article: Armored TGFβRIIDN ROR1-CAR T cells reject solid tumors and resist suppression by constitutively-expressed and treatment-induced TGFβ1
Armored TGFβRIIDN ROR1-CAR T cells reject solid tumors and resist suppression by constitutively-expressed and treatment-induced TGFβ1 Open
Background Chimeric antigen receptor (CAR) T-cell therapy target receptor tyrosine kinase-like orphan receptor 1 (ROR1) is broadly expressed in hematologic and solid tumors, however clinically-characterized ROR1-CAR T cells with single cha…
View article: Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes
Microbiome Shapes the T Cell Receptor Repertoire among CD4+CD8+ Thymocytes Open
The microbiome shapes the mature T cell receptor (TCR) repertoire and thereby influences pathogen control. To investigate microbiome influences on T cells at an earlier, immature stage, we compared single-cell TCR transcript sequences betw…
View article: 287 Novel, boosted, fully human ROR1-targeting CAR T cells effectively eliminate hematologic and solid tumors, and resist tumor microenvironment
287 Novel, boosted, fully human ROR1-targeting CAR T cells effectively eliminate hematologic and solid tumors, and resist tumor microenvironment Open
Background Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is widely expressed in various hematologic and solid tumors. A clinical trial employing ROR1-CAR T-cells with scFv-R12 binder showed poor tumor infiltration and dysfunctiona…
View article: 253 Fully human CD123 CAR T cells irradicate AML in pre-clinical models and exhibit a favorable safety profile
253 Fully human CD123 CAR T cells irradicate AML in pre-clinical models and exhibit a favorable safety profile Open
Background CD123, the interleukin-3 receptor alpha chain (IL-3Ra), is widely overexpressed in hematologic malignancies including acute myeloid leukemia (AML), at both the level of leukemic stem cells (LSCs) and leukemic blasts. This makes …
View article: Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β
Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β Open
CAR T-cell therapies targeting the B-cell maturation antigen eliminate tumors in relapsed/refractory multiple myeloma patients, however durable remissions remain difficult to attain. Transforming growth factor beta (TGF-β) is a multifuncti…
View article: A comprehensive collection of systems biology data characterizing the host response to viral infection
A comprehensive collection of systems biology data characterizing the host response to viral infection Open
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcri…
View article: A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans Open
T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by d…
View article: Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation
Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation Open
Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T cells…
View article: Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells
Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells Open
Aims New therapeutics for the control of influenza virus infections are needed to alleviate the burden caused by seasonal epidemics and occasional pandemics, and to overcome the potential risk of drug-resistance emergence. Enisamium iodide…
View article: VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity Open
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translati…
View article: MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates Open
Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-con…
View article: Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis
Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis Open
Transgenic expression of antigen-specific T-cell receptor (TCR) genes is a promising approach for immunotherapy against infectious diseases and cancers. A key to the efficient application of this approach is the rapid and specific isolatio…
View article: Paired TCRαβ analysis of virus‐specific CD8<sup>+</sup> T cells exposes diversity in a previously defined ‘narrow’ repertoire
Paired TCRαβ analysis of virus‐specific CD8<sup>+</sup> T cells exposes diversity in a previously defined ‘narrow’ repertoire Open
T‐cell receptor (TCR) usage has an important role in determining the outcome of CD8 + cytotoxic T‐lymphocyte responses to viruses and other pathogens. However, the characterization of TCR usage from which such conclusions are drawn is base…
View article: Zoledronic Acid-Mediated Ex Vivo Expansion and Function of Human Umbilical Cord Blood Gamma Delta T Cells Is Distinct from Human Peripheral Blood Gamma Delta T Cells
Zoledronic Acid-Mediated Ex Vivo Expansion and Function of Human Umbilical Cord Blood Gamma Delta T Cells Is Distinct from Human Peripheral Blood Gamma Delta T Cells Open
Ex vivo expansion of human peripheral blood (PB) gamma delta T cells, specifically the Vγ9Vδ2 subset, using aminobisphosphonates (NBPs) has been extensively studied. Reports suggest that NPBs can also stimulate human umbilical cord blood (…