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View article: Measurement of Androgen‐Sensitive Preweaning Developmental Landmarks in Rodents: Best Practices and Toxicological Significance
Measurement of Androgen‐Sensitive Preweaning Developmental Landmarks in Rodents: Best Practices and Toxicological Significance Open
Background Anogenital distance and nipple/areola(e) retention are biomarkers for monitoring normal age‐appropriate masculinization of male offspring required by U.S. EPA and OECD guidelines for chemicals. OECD Guidance Document 150 conside…
View article: Abstracts
Abstracts Open
I am pleased to invite you to attend the 61st Annual Meeting of the Society for Birth Defects Research and Prevention, a fully online, virtual experience that will take place weekdays from June 24 to July 1, 2021, with three Education Cour…
View article: Extended One-Generation Reproductive Toxicity (EOGRT) study of benzoic acid in Sprague Dawley rats
Extended One-Generation Reproductive Toxicity (EOGRT) study of benzoic acid in Sprague Dawley rats Open
Benzoic acid (BA) was administered in the diet to male and female Sprague Dawley Crl:CD(SD) rats in an OECD Test Guideline 443 Extended One-Generation Reproductive Toxicity (EOGRT) study to test for effects that may occur as a result of pr…
View article: Issue Information
Issue Information Open
Choline ameliorates
View article: Response to the comments of Runyan et al. on “Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats”
Response to the comments of Runyan et al. on “Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats” Open
As stated in our Introduction, DeSesso et al. (2019) attempted to replicate the Johnson, Goldberg, Mays, and Dawson (2003) trichloroethylene (TCE) drinking water study in pregnant rats, which reported “abnormal hearts” among offspring of t…
View article: Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats
Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats Open
Background Trichloroethylene (TCE) was negative for developmental toxicity after inhalation and oral gavage exposure of pregnant rats but fetal cardiac defects were reported following drinking water exposure throughout gestation. Because o…
View article: Report from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points
Report from the BfR expert hearing on practicability of hormonal measurements: recommendations for experimental design of toxicological studies with integrated hormonal end points Open
This publication summarizes discussions that were held during an international expert hearing organized by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany, in October 2017. The expert hearing was dedicated to prov…
View article: Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice
Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice Open
Potassium perfluorohexanesulfonate (K+PFHxS) was evaluated for reproductive/developmental toxicity in CD-1 mice. Up to 3 mg/kg-d K+PFHxS was administered (n = 30/sex/group) before mating, for at least 42 days in F0 males, and for F0 female…
View article: Rethinking developmental toxicity testing: Evolution or revolution?
Rethinking developmental toxicity testing: Evolution or revolution? Open
Background Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound to pregnant laboratory animals. After more than 50 years of embryo‐fetal development testing, ar…
View article: Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague‐Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression
Changes in Sensitivity to the Effects of Atrazine on the Luteinizing Hormone Surge in Female Sprague‐Dawley Rats after Repeated Daily Doses: Correlation with Liver Enzyme Expression Open
Background Atrazine suppression of the LH surge slowly develops over time and peaks after 4 days; sensitivity to atrazine decreases after 8 or 14 days of dosing. Adaptation of the LH response was correlated with increased phase I and phase…
View article: Changes in hepatic phase I and phase II biotransformation enzyme expression and glutathione levels following atrazine exposure in female rats
Changes in hepatic phase I and phase II biotransformation enzyme expression and glutathione levels following atrazine exposure in female rats Open
1. To determine the effects of repeated atrazine (ATR) treatment on hepatic phase I and II enzymes, adult female rats were treated with vehicle or 100 mg/kg of ATR for 1, 2, 3 or 4 days. Glutathione-s-transferases (GST) mRNA expression, pr…
View article: Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation
Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation Open
T cell-dependent IgM antibody production and natural killer cell (NKC) activity were assessed in SD rats orally administered atrazine for 28 days to males (0, 6.5, 25, or 100 mg/kg/day) or females (0, 3, 6, or 50 mg/kg/day), or 30 or 500 p…
View article: Effect of Age, Duration of Exposure, and Dose of Atrazine on Sexual Maturation and the Luteinizing Hormone Surge in the Female Sprague–Dawley Rat
Effect of Age, Duration of Exposure, and Dose of Atrazine on Sexual Maturation and the Luteinizing Hormone Surge in the Female Sprague–Dawley Rat Open
Atrazine (ATZ) was administered daily by gavage to pregnant female Sprague Dawley rats at doses of 0, 6.25, 25 or 50 mg/kg/day, either during gestation, lactation and post‐weaning (G/L/PW cohort) to F 1 generation female offspring or only …