Pragya D. Yadav
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View article: ANN-Powered Automatic Calculation for Fire Sprinkler Head Needed for Random Car Parking Basement Area
ANN-Powered Automatic Calculation for Fire Sprinkler Head Needed for Random Car Parking Basement Area Open
The increasing complexity of fire safety in basement car parking structures, compounded by high fire loads, limited ventilation, and vehicle fires, challenges the adequacy of conventional sprinkler design methods prescribed by standards su…
View article: ANN Applications in Automatic Fire Sprinkler Head Calculation for Car Parking Basements: A Comprehensive Review
ANN Applications in Automatic Fire Sprinkler Head Calculation for Car Parking Basements: A Comprehensive Review Open
manually often involves repetitive tasks, high workloads, and the risk of human error. To address this, the present study proposes an intelligent framework that automates the sprinkler layout design process. A dataset of 60 existing sprink…
View article: Steroidal Alkaloids from <i>Sarcococca saligna</i> (Buxaceae): In Vitro and In Silico Evaluation of Their Cytotoxic Potential
Steroidal Alkaloids from <i>Sarcococca saligna</i> (Buxaceae): In Vitro and In Silico Evaluation of Their Cytotoxic Potential Open
Sarcococca saligna (S. saligna), a medicinal shrub rich in therapeutic steroidal alkaloids (SAs), is ethnomedicinally used to treat ulcers, tumors, and wounds. In this study, to explore the anticancer potential of S. salig…
View article: Unravelling ecological factors influencing phylodynamics of Kyasanur Forest Disease in India
Unravelling ecological factors influencing phylodynamics of Kyasanur Forest Disease in India Open
Kyasanur Forest Disease Virus (KFDV) is a tick-borne flavivirus endemic to the Western Ghats region of India, with increasing reports of geographic expansion. This study employs phylogenetic analysis and spatial diffusion modeling to under…
View article: Editorial: Emerging SARS-COV-2 variants: genomic variations, transmission, pathogenesis, clinical impact and interventions, volume III
Editorial: Emerging SARS-COV-2 variants: genomic variations, transmission, pathogenesis, clinical impact and interventions, volume III Open
View article: Expanding mpox surveillance: a community-centric approach using discarded condoms
Expanding mpox surveillance: a community-centric approach using discarded condoms Open
Within short span of two years, the WHO has declared emergence of mpox as Public health emergency of international concern (PHEIC) in 2022 and 2024. As Mpox challenges the global public health system, traditional surveillance emerges as in…
View article: Medical Chatbot using LLM, Faiss & LangChain
Medical Chatbot using LLM, Faiss & LangChain Open
By providing automated symptom analysis, prescription suggestions, and patient support, AI-powered medical chatbots are revolutionizing digital healthcare. This work introduces a sophisticated chatbot that combines FAISS for quick and prec…
View article: Comprehensive immunoinformatics and bioinformatics strategies for designing a multi-epitope based vaccine targeting structural proteins of Nipah virus
Comprehensive immunoinformatics and bioinformatics strategies for designing a multi-epitope based vaccine targeting structural proteins of Nipah virus Open
Background Nipah virus (NiV) is characterized by recurring outbreaks and causes severe neurological impact, leading to increased mortality rates. Despite the severity of the disease, there is no proven post-exposure treatment available, em…
View article: Encephalitis-predominant Nipah virus outbreaks in Kerala, India during 2024
Encephalitis-predominant Nipah virus outbreaks in Kerala, India during 2024 Open
View article: Genetic stability of Mpox virus during in-vitro serial passaging: Insights from mutational analysis
Genetic stability of Mpox virus during in-vitro serial passaging: Insights from mutational analysis Open
View article: Construction of an immunoinformatics-based multi-epitope vaccine candidate targeting Kyasanur forest disease virus
Construction of an immunoinformatics-based multi-epitope vaccine candidate targeting Kyasanur forest disease virus Open
Kyasanur forest disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus (KFDV) was initially considered endemic to the Western Ghats region of Karnataka state in India. Over the years, there have been reports of its spre…
View article: Applications of Microfluidics in Biomedical and Pharmaceutical Fields -An Overview
Applications of Microfluidics in Biomedical and Pharmaceutical Fields -An Overview Open
View article: Nipah virus survey in Pteropus medius of eastern and northeastern region of India, 2022–2023
Nipah virus survey in Pteropus medius of eastern and northeastern region of India, 2022–2023 Open
Introduction India has experienced seven outbreaks of the Nipah virus (NiV) since 2001, primarily occurring in the southern and eastern regions of the country. The southern region has been the main site for these outbreaks. In contrast, th…
View article: Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India
Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India Open
Kerala, a south Indian state witnessed several outbreaks of Nipah encephalitis since 2018, a zoonotic viral disease with significant pandemic potential. This review highlights the relevance of surveillance and health system preparedness, i…
View article: Genomic analysis confirmed the importation of first mPox Clade Ib case in Kerala, India from Dubai, UAE
Genomic analysis confirmed the importation of first mPox Clade Ib case in Kerala, India from Dubai, UAE Open
View article: Humoral and cellular immune response to AZD1222 /Covishield and BV152/Covaxin COVID-19 vaccines among adults in India
Humoral and cellular immune response to AZD1222 /Covishield and BV152/Covaxin COVID-19 vaccines among adults in India Open
Several COVID-19 vaccines were developed using different approaches to prevent both symptomatic COVID-19 cases and fatalities. The adults were vaccinated with two doses of AZD1222/Covishield (n = 77) [manufactured by Serum Institute…
View article: Phylo-geo haplotype network-based characterization of SARS-CoV-2 strains circulating in India (2020-2022)
Phylo-geo haplotype network-based characterization of SARS-CoV-2 strains circulating in India (2020-2022) Open
Background & objectives Genetic analysis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) strains circulating in India during 2020-2022 was carried out to understand the evolution of potentially expanding and divergent clade…
View article: Cost-effectiveness of COVID rapid diagnostic tests for patients with severe/critical illness in low- and middle-income countries: A modeling study
Cost-effectiveness of COVID rapid diagnostic tests for patients with severe/critical illness in low- and middle-income countries: A modeling study Open
Background Rapid diagnostic tests (RDTs) for coronavirus disease (COVID) are used in low- and middle-income countries (LMICs) to inform treatment decisions. However, to date, it is unclear when this use is cost-effective. Existing analyses…
View article: Immunodeficiency-Related Vaccine-Derived Poliovirus (iVDPV) Excretion in an Infant with Severe Combined Immune Deficiency with Spillover to a Parent
Immunodeficiency-Related Vaccine-Derived Poliovirus (iVDPV) Excretion in an Infant with Severe Combined Immune Deficiency with Spillover to a Parent Open
In order to maintain the polio eradication status, it has become evident that the surveillance of cases with acute flaccid paralysis and of environmental samples must be urgently supplemented with the surveillance of poliovirus excretions …
View article: Multi-epitope vaccine design using in silico analysis of glycoprotein and nucleocapsid of NIPAH virus
Multi-epitope vaccine design using in silico analysis of glycoprotein and nucleocapsid of NIPAH virus Open
According to the 2018 WHO R&D Blueprint, Nipah virus (NiV) is a priority disease, and the development of a vaccine against NiV is strongly encouraged. According to criteria used to categorize zoonotic diseases, NiV is a stage III disease t…
View article: Comprehensive Genomics Investigation of Neboviruses Reveals Distinct Codon Usage Patterns and Host Specificity
Comprehensive Genomics Investigation of Neboviruses Reveals Distinct Codon Usage Patterns and Host Specificity Open
Neboviruses (NeVs) from the Caliciviridae family have been linked to enteric diseases in bovines and have been detected worldwide. As viruses rely entirely on the cellular machinery of the host for replication, their ability to thrive in a…
View article: Construction of an Immunoinformatics-Based Multi-Epitope Vaccine Candidate targeting Kyasanur Forest Disease Virus
Construction of an Immunoinformatics-Based Multi-Epitope Vaccine Candidate targeting Kyasanur Forest Disease Virus Open
Kyasanur Forest Disease (KFD) is one of the neglected tick-borne viral zoonoses. KFD virus was initially considered endemic to the Western Ghats region of Karnataka. Still, over the years, there have been reports of its spread to newer are…
View article: Surveillance of Nipah virus in Pteropus medius of Kerala state, India, 2023
Surveillance of Nipah virus in Pteropus medius of Kerala state, India, 2023 Open
Introduction Since 2018, the Indian state of Kerala has reported four Nipah virus (NiV) disease outbreaks, raising concerns about NiV spillover from bats to the human population. Considering this, a cross-sectional study was undertaken in …
View article: Emergence of Recombinant Subclade D3/Y in Coxsackievirus A6 Strains in Hand-Foot-and-Mouth Disease (HFMD) Outbreak in India, 2022
Emergence of Recombinant Subclade D3/Y in Coxsackievirus A6 Strains in Hand-Foot-and-Mouth Disease (HFMD) Outbreak in India, 2022 Open
Coxsackievirus-A6 (CV-A6) is responsible for more severe dermatological manifestations compared to other enteroviruses such as CV-A10, CV-A16, and EV-A71, causing HFMD in children and adults. Between 2005 and 2007, the recombinant subclade…
View article: Neutralizing antibody responses to SARS-CoV-2 Omicron variants: Post six months following two-dose & three-dose vaccination of ChAdOx1 nCoV-19 or BBV152
Neutralizing antibody responses to SARS-CoV-2 Omicron variants: Post six months following two-dose & three-dose vaccination of ChAdOx1 nCoV-19 or BBV152 Open
Background & objectives: The Omicron sub-lineages are known to have higher infectivity, immune escape and lower virulence. During December 2022 - January 2023 and March - April 2023, India witnessed increased SARS-CoV-2 infections, mostly …
View article: Comparison of SARS-CoV-2 VOC 202012/01 (UK variant) and D614G variant transmission by different routes in Syrian hamsters
Comparison of SARS-CoV-2 VOC 202012/01 (UK variant) and D614G variant transmission by different routes in Syrian hamsters Open
Many SARS-CoV-2 variants of concern has been reported recently which were linked to increased transmission. In our earlier study on virus shedding using VOC 202012/01(UK variant) and D614G variant in hamster model, we observed significantl…
View article: Methodological and interpretative considerations in the study of the first Kyasanur Forest disease outbreak in Goa, India
Methodological and interpretative considerations in the study of the first Kyasanur Forest disease outbreak in Goa, India Open
Munivenkatappa, Ashok1; Pattassery, Sakib Akther1; Shettar, Annapurna K2; Yadav, Pragya D3 Author Information
View article: A novel highly divergent enteric calicivirus in a bovine calf, India
A novel highly divergent enteric calicivirus in a bovine calf, India Open
A novel highly divergent bovine calicivirus was identified in an Indian calf experiencing enteritis. The whole genome sequencing revealed distinct amino acid motifs in the open reading frame (ORF1) polyprotein, which are unique to calicivi…
View article: Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics
Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics Open
The uncontrolled spread of drug-resistant tuberculosis (DR-TB) clinical cases necessitates the urgent discovery of newer chemotypes with novel mechanisms of action. Here, we report the chemical synthesis of rationally designed novel transi…
View article: “We usually see a lot of delay in terms of coming for or seeking care”: an expert consultation on COVID testing and care pathways in seven low- and middle-income countries
“We usually see a lot of delay in terms of coming for or seeking care”: an expert consultation on COVID testing and care pathways in seven low- and middle-income countries Open
Background Rapid diagnostic testing may support improved treatment of COVID patients. Understanding COVID testing and care pathways is important for assessing the impact and cost-effectiveness of testing in the real world, yet there is lim…