Prateek Pathak
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View article: Prevention of Secured websites from Downgrade and MITM attacks through Blocash Technology
Prevention of Secured websites from Downgrade and MITM attacks through Blocash Technology Open
Online transaction websites face persistent threats from SSL strip, downgrade, and man-in-the-middle attacks, which exploit vulnerabilities in SSL/TLS protocols to intercept sensitive user data. Traditional reliance on transport-layer secu…
View article: Hysterosalpingographic Evaluation of Infertile Women in Tertiary Care Center
Hysterosalpingographic Evaluation of Infertile Women in Tertiary Care Center Open
BackgroundInfertility refers to a inability of couple to achieve pregnancy after one year of consistent, unprotected intercourse. Conditions involving the fallopian tubes are responsible for an estimated 35–40% of female infertility cases.…
View article: Exploring GPR120/FFAR4 pharmacology: Unveiling novel therapeutic avenues through molecular signaling pathways for Alzheimer's disease intervention
Exploring GPR120/FFAR4 pharmacology: Unveiling novel therapeutic avenues through molecular signaling pathways for Alzheimer's disease intervention Open
G-protein-coupled receptors (GPCRs) are a major class of membrane proteins involved in numerous physiological and pathological processes. Among them, free fatty acid receptor 4 (FFAR4/GPR120), activated by long-chain free fatty acids, has …
View article: Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential
Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential Open
Hepatitis is a significant cause of severe liver diseases, including cirrhosis, liver failure, and hepatocellular carcinoma. Current strategies include antiviral drugs, vaccination, and liver transplantation; however, a potential therapeut…
View article: Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders
Exosomal non-coding RNAs: key regulators of inflammation-related cardiovascular disorders Open
Inflammation is a complex, tightly regulated process involving biochemical and cellular reactions to harmful stimuli. Often termed "the internal fire", it is crucial for protecting the body and facilitating tissue healing. While inflammati…
View article: Investigation of Hexamethylenetetramine Adsorption Isotherms on Clay Particles and Investigation of Adsorption Thermodynamics and Mechanism
Investigation of Hexamethylenetetramine Adsorption Isotherms on Clay Particles and Investigation of Adsorption Thermodynamics and Mechanism Open
This study investigated the adsorption capacity and thermodynamics of hexamethylenetetramine (HMTA) on kaolinite particles. Considering the importance of HMTA in gel injection and clay stabilizing, investigating the adsorption process of t…
View article: Catalytic exploration metallic and nonmetallic nano-catalysts, properties, role in photoelectrochemistry for sustainable applications
Catalytic exploration metallic and nonmetallic nano-catalysts, properties, role in photoelectrochemistry for sustainable applications Open
This article provides an overview of the photoelectrochemistry of nano-catalysts, their advantages, mechanisms, and the interactions between nanostructures and reactivity. The applications of nanomaterials in various processes, such as dye…
View article: Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective
Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective Open
Normal and oncogenic RAS signalling pathway along with inhibitors.
View article: Robustic and hybrid cobalt doped BaFe12O19 hexaferrites for the photocatalytic degradation of Congo Red for wastewater treatment
Robustic and hybrid cobalt doped BaFe12O19 hexaferrites for the photocatalytic degradation of Congo Red for wastewater treatment Open
The industrial sector faces a significant challenge in finding the highly effective and efficient treatments for harmful dye-based color effluents. In this study, pure and cobalt doped barium hexaferrite of chemical formula, Ba1-xCoxFe12O1…
View article: Citric acid based (CQDs/TiO2) nanocomposites against SARS-COV-2: theoretical, photocatalytic and computational studies
Citric acid based (CQDs/TiO2) nanocomposites against SARS-COV-2: theoretical, photocatalytic and computational studies Open
In the last decade, carbon quantum dots (CQDs), a novel class of carbon-based nanomaterials, have received increasing attention due to their distinct properties. Carbon Quantum Dots/Titanium Dioxide (CQDs/TiO2) Nanocomposites were reported…
View article: In-Vitro evaluation of antidiabetic, antioxidant, and anti-inflammatory activities in Mucuna pruriens seed extract
In-Vitro evaluation of antidiabetic, antioxidant, and anti-inflammatory activities in Mucuna pruriens seed extract Open
Background Mucuna pruriens var. utilis (Wall. ex Wight) belonging to the family Fabaceae. Renowned for its diverse array of phytochemicals, this plant has been historically employed in the treatment of various ailments. The objectives of t…
View article: Wound healing, antidiabetic and antioxidant activity of Neolamarckia cadamba, quercetin rich, extract
Wound healing, antidiabetic and antioxidant activity of Neolamarckia cadamba, quercetin rich, extract Open
Introduction: Traditional Chinese Medicine (TCM), Neolamarckia cadamba (NMCA), a member of the Rubiaceae family, is well-known for its rich assortment of phytochemicals and has a historical use in addressing various health issues. Querceti…
View article: Harnessing Luteolin's therapeutic potential in human disorders: Medicinal significance, biological, clinical properties and analytical aspects
Harnessing Luteolin's therapeutic potential in human disorders: Medicinal significance, biological, clinical properties and analytical aspects Open
Introduction: Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a common flavonoid in many fruits, vegetables, and medicinal herbs. Plants rich in luteolin have been used in Chinese traditional medicine for treating various diseases, such as hyp…
View article: Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective
Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective Open
Semisynthetic phytochemicals in cancer treatment.
View article: Oral isotretinoin induced giant lobular capillary haemangioma over scalp: a rare case report
Oral isotretinoin induced giant lobular capillary haemangioma over scalp: a rare case report Open
With the advent of isotretinoin in the last 2 decades, dermatotheraputics has reached a major milestone especially in treating moderate to severe acne. Oral isotretinoin is an isomer of all-trans retinoic acid and a metabolite of retinol (…
View article: Androgenetic alopecia: evaluation of hormonal profile and its systemic implications
Androgenetic alopecia: evaluation of hormonal profile and its systemic implications Open
Background: Androgenetic Alopecia is a hereditary androgen-dependent disorder characterized by a gradual conversion of terminal hair into miniaturized hair with typical bitemporal recession and balding vertex and is considered the most com…
View article: Halo scalp ring: an undiagnosed neonatal scalp alopecia
Halo scalp ring: an undiagnosed neonatal scalp alopecia Open
Halo scalp ring is a rare less frequently diagnosed non scarring alopecia seen in neonatal period. Although a few cases can land up in scarring alopecia if necrosis and deep inflammation due to Caput Succedeneum supervenes. It is imperativ…
View article: Efficacy of intralesional measles, mumps and rubella vaccine immunotherapy in Molluscum contagiosum: a prospective study
Efficacy of intralesional measles, mumps and rubella vaccine immunotherapy in Molluscum contagiosum: a prospective study Open
Introduction Molluscum contagiosum(MC) is a viral infection of the skin and mucous membrane characterized by single or multiple, pearly white to flesh-colored umbilicated papules. There are certain therapies that increase the cellular immu…
View article: Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022
Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022 Open
Serine/threonine-protein kinase B-Raf (BRAF; RAF = rapidly accelerated fibrosarcoma) plays an important role in the mitogen-activated protein kinase (MAPK) signaling cascade. Somatic mutations in the BRAF gene were first discovered in 2002…
View article: Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective
Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective Open
Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a d…
View article: MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives
MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives Open
MEK1/2 are critical components of RAS–RAF–MEK–ERK or MAPK signalling pathway.
View article: A Novel Tractor Operated Grass Seed Harvester Developed in India
A Novel Tractor Operated Grass Seed Harvester Developed in India Open
The demand of green and dry fodder in India is estimated to increase to 1170 and 650 m tonne whereas availability is expected to be at 411.3 and 488 m tonne in 2025, respectively, depicting deficit of about 64.9% green fodder and 24.9% dry…
View article: Design, one-pot synthesis, computational and biological evaluation of diaryl benzimidazole derivatives as MEK inhibitors
Design, one-pot synthesis, computational and biological evaluation of diaryl benzimidazole derivatives as MEK inhibitors Open
MEK mutations are more common in various human malignancies, such as pancreatic cancer (70–90%), mock melanoma (50%), liver cancer (20–40%), colorectal cancer (25–35%), melanoma (15–20%), non-small cell lung cancer (10–20%) and basal breas…
View article: Guava Leaf Essential Oil as a Potent Antioxidant and Anticancer Agent: Validated through Experimental and Computational Study
Guava Leaf Essential Oil as a Potent Antioxidant and Anticancer Agent: Validated through Experimental and Computational Study Open
Several drugs now employed in cancer therapy were discovered as a result of anticancer drug research based on natural products. Here, we reported the in vitro antioxidant and anticancer activity followed by in silico anticancer and estroge…
View article: Cucumis melo Var. agrestis Naudin as a potent antidiabetic: Investigation via experimental methods
Cucumis melo Var. agrestis Naudin as a potent antidiabetic: Investigation via experimental methods Open
Background: The present study reveals that the ethanolic extract of Cucumis melo var. agrestis (CMVA), can influence the activity of blood glucose level, insulin level, oxidative stress, and lipid profile in Alloxan monohydrate induced dia…
View article: Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids Open
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination …
View article: Debelalactone Prevents Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress on Male Wistar Rats
Debelalactone Prevents Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress on Male Wistar Rats Open
The current study was conducted to exemplify the effect of debelalactone on tissue protection, chronic hepatic inflammation, hepatic protection and oxidative stress induced by diethyl nitrosamine in Wistar rats. Therefore, DEN (200 mg/kg) …