Prajan Subedi
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View article: Hemorheological, cardiorespiratory, and cerebrovascular effects of pentoxifylline following acclimatization to 3,800 m
Hemorheological, cardiorespiratory, and cerebrovascular effects of pentoxifylline following acclimatization to 3,800 m Open
We conducted a double-blind, placebo-controlled study on the rheological, cardiorespiratory and cerebrovascular effects of acute pentoxifylline in healthy lowlanders after 11–14 days at 3,800 m. Although red blood cell deformability was re…
View article: Manipulation of iron status on cerebral blood flow at high altitude in lowlanders and adapted highlanders
Manipulation of iron status on cerebral blood flow at high altitude in lowlanders and adapted highlanders Open
Cerebral blood flow (CBF) increases during hypoxia to counteract the reduction in arterial oxygen content. The onset of tissue hypoxemia coincides with the stabilization of hypoxia-inducible factor (HIF) and transcription of downstream HIF…
View article: Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude
Pulmonary vascular reactivity to supplemental oxygen in Sherpa and lowlanders during gradual ascent to high altitude Open
Prolonged alveolar hypoxia leads to pulmonary vascular remodelling. We examined the time course at altitude, over which hypoxic pulmonary vasoconstriction goes from being acutely reversible to potentially irreversible. Study subjects were …
View article: Left Ventricular Twist Is Augmented in Hypoxia by β <sub>1</sub> -Adrenergic–Dependent and β <sub>1</sub> -Adrenergic–Independent Factors, Without Evidence of Endocardial Dysfunction
Left Ventricular Twist Is Augmented in Hypoxia by β <sub>1</sub> -Adrenergic–Dependent and β <sub>1</sub> -Adrenergic–Independent Factors, Without Evidence of Endocardial Dysfunction Open
Background: Left ventricular (LV) twist mechanics are augmented with both acute and chronic hypoxemia. Although the underlying mechanisms remain unknown, sympathetic activation and a direct effect of hypoxemia on the myocardium have been p…
View article: UBC-Nepal Expedition: An experimental overview of the 2016 University of British Columbia Scientific Expedition to Nepal Himalaya
UBC-Nepal Expedition: An experimental overview of the 2016 University of British Columbia Scientific Expedition to Nepal Himalaya Open
The University of British Columbia Nepal Expedition took place over several months in the fall of 2016 and was comprised of an international team of 37 researchers. This paper describes the objectives, study characteristics, organization a…
View article: The independent effects of hypovolaemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m
The independent effects of hypovolaemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m Open
Key points We sought to determine the isolated and combined influence of hypovolaemia and hypoxic pulmonary vasoconstriction on the decrease in left ventricular (LV) function and maximal exercise capacity observed under hypobaric hypoxia. …
View article: Influence of myocardial oxygen demand on the coronary vascular response to arterial blood gas changes in humans
Influence of myocardial oxygen demand on the coronary vascular response to arterial blood gas changes in humans Open
It remains unclear if the human coronary vasculature is inherently sensitive to changes in arterial Po 2 and Pco 2 or if coronary vascular responses are the result of concomitant increases in myocardial O 2 consumption/demand ([Formula: se…
View article: One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia
One session of remote ischemic preconditioning does not improve vascular function in acute normobaric and chronic hypobaric hypoxia Open
New Findings What is the central question of this study? It is suggested that remote ischemic preconditioning (RIPC) might offer protection against ischaemia–reperfusion injuries, but the utility of RIPC in high‐altitude settings remains u…
View article: Adenosine receptor-dependent signaling is not obligatory for normobaric and hypobaric hypoxia-induced cerebral vasodilation in humans
Adenosine receptor-dependent signaling is not obligatory for normobaric and hypobaric hypoxia-induced cerebral vasodilation in humans Open
Hypoxia increases cerebral blood flow (CBF) with the underlying signaling processes potentially including adenosine. A randomized, double-blinded, and placebo-controlled design, was implemented to determine if adenosine receptor antagonism…
View article: The effect of α<sub>1</sub>‐adrenergic blockade on post‐exercise brachial artery flow‐mediated dilatation at sea level and high altitude
The effect of α<sub>1</sub>‐adrenergic blockade on post‐exercise brachial artery flow‐mediated dilatation at sea level and high altitude Open
Key points Our objective was to quantify endothelial function (via brachial artery flow‐mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and following both maximal exercise and 30 min of moderate‐intensity cycli…