Prajna Lalitha
YOU?
Author Swipe
View article: Trends in aetiology and antibiotic resistance in bacterial keratitis isolates from South India between 2013-2024
Trends in aetiology and antibiotic resistance in bacterial keratitis isolates from South India between 2013-2024 Open
Aim: To measure aetiology and antibiotic resistance (AMR) trends of bacteria cultured from corneal scrapings from patients with infectious keratitis at a tertiary referral hospital in South India. Methods: In this retrospective study, bact…
View article: Fusarium spp. and Aspergillus flavus infection induces pathogen-specific and pathogen-independent host immune response in patients with fungal keratitis
Fusarium spp. and Aspergillus flavus infection induces pathogen-specific and pathogen-independent host immune response in patients with fungal keratitis Open
Introduction Fungal keratitis, caused primarily by Fusarium spp. and Aspergillus flavus , is a significant cause of corneal blindness, particularly in tropical regions. Current antifungal agents like natamycin and voriconazole have limited…
View article: Automated Detection of Filamentous Fungal Keratitis on Whole Slide Images of Potassium Hydroxide Smears with Multiple Instance Learning
Automated Detection of Filamentous Fungal Keratitis on Whole Slide Images of Potassium Hydroxide Smears with Multiple Instance Learning Open
View article: Clinical Evaluation of a Novel CRISPR-Cas12a-Based RID-MyC Assay for the Diagnosis of Fungal Endophthalmitis
Clinical Evaluation of a Novel CRISPR-Cas12a-Based RID-MyC Assay for the Diagnosis of Fungal Endophthalmitis Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Association between in vitro susceptibility and clinical outcomes in fungal keratitis
Association between in vitro susceptibility and clinical outcomes in fungal keratitis Open
Purpose The purpose of this study was to assess the association between antifungal susceptibility as measured by minimum inhibitory concentration (MIC) and clinical outcomes in fungal keratitis. Methods This pre-specified secondary analysi…
View article: A double-masked, sham-controlled trial of rose bengal photodynamic therapy for the treatment of fungal and acanthamoeba keratitis: Rose Bengal Electromagnetic Activation with Green Light for Infection Reduction (REAGIR) study
A double-masked, sham-controlled trial of rose bengal photodynamic therapy for the treatment of fungal and acanthamoeba keratitis: Rose Bengal Electromagnetic Activation with Green Light for Infection Reduction (REAGIR) study Open
Background Infectious keratitis secondary to fungus or acanthamoeba often has a poor outcome despite receiving the best available medical therapy. In vitro rose bengal photodynamic therapy (RB-PDT) appears to be effective against fungal an…
View article: Association of Weather Variables With Pathogens Contributing to Conjunctivitis Worldwide
Association of Weather Variables With Pathogens Contributing to Conjunctivitis Worldwide Open
Purpose To identify weather variables associated with pathogens contributing to infectious conjunctivitis globally. Methods Sample collection and pathogen identification from patients with acute infectious conjunctivitis was performed from…
View article: A double-masked, sham-controlled trial of rose bengal photodynamic therapy for the treatment of fungal and acanthameoba keratitis: Rose Bengal Electromagnetic Activation with Green Light for Infection Reduction (REAGIR) Study
A double-masked, sham-controlled trial of rose bengal photodynamic therapy for the treatment of fungal and acanthameoba keratitis: Rose Bengal Electromagnetic Activation with Green Light for Infection Reduction (REAGIR) Study Open
View article: Melanin depletion affects Aspergillus flavus conidial surface proteins, architecture, and virulence
Melanin depletion affects Aspergillus flavus conidial surface proteins, architecture, and virulence Open
View article: Uncommon case of isolated conjunctival histoplasmosis: A rare clinical entity
Uncommon case of isolated conjunctival histoplasmosis: A rare clinical entity Open
We report an unusual case of isolated conjunctival histoplasmosis in a healthy immunocompetent patient. A 62-year-old male presented with a gradually progressing, painless, fleshy mass in both eyes for 2 months. On examination, a diffuse, …
View article: Development and Clinical Evaluation of a CRISPR/Cas12a-Based Nucleic Acid Detection Platform for the Diagnosis of Keratomycoses
Development and Clinical Evaluation of a CRISPR/Cas12a-Based Nucleic Acid Detection Platform for the Diagnosis of Keratomycoses Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Vision-Related Quality of Life Outcomes in Patients Treated for Filamentous Fungal Keratitis in the CLAIR Trial
Vision-Related Quality of Life Outcomes in Patients Treated for Filamentous Fungal Keratitis in the CLAIR Trial Open
Purpose To analyze vision-related quality of life in patients with fungal keratitis treated with topical antifungal medications and adjuvant crosslinking in the Cross-Linking Assisted Infection Reduction (CLAIR) trial Methods Study partici…
View article: Pathogen Surveillance for Acute Infectious Conjunctivitis
Pathogen Surveillance for Acute Infectious Conjunctivitis Open
Importance Acute infectious conjunctivitis is a common ocular condition with major public health consequences. Objective To assess regional variations and microbial etiologies of acute infectious conjunctivitis to guide treatment. Design, …
View article: Rapid Point-of-Care Identification of <i>Aspergillus</i> Species in Microbial Keratitis
Rapid Point-of-Care Identification of <i>Aspergillus</i> Species in Microbial Keratitis Open
Importance Microbial keratitis (MK) is a common cause of unilateral visual impairment, blindness, and eye loss in low-income and middle-income countries. There is an urgent need to develop and implement rapid and simple point-of-care diagn…
View article: Heterogenous pathogen profile associated with acute conjunctivitis in Nepal
Heterogenous pathogen profile associated with acute conjunctivitis in Nepal Open
Background Infectious conjunctivitis is common in Nepal. Materials and Methods This prospective study recruited 60 patients with presumed acute infectious conjunctivitis from the B.P. Koirala Lions Center for Ophthalmic Studies in Kathmand…
View article: Assessing the Impact of Image Quality on Deep Learning Classification of Infectious Keratitis
Assessing the Impact of Image Quality on Deep Learning Classification of Infectious Keratitis Open
View article: Apollo Rising: Acute Conjunctivitis Outbreak in India, 2022
Apollo Rising: Acute Conjunctivitis Outbreak in India, 2022 Open
Purpose: The purpose of this study was to identify pathogens associated with the 2022 conjunctivitis outbreak in Tamil Nadu, India. Methods: This prospective study was conducted in November 2022. Patients with presumed acute infectious con…
View article: DRIVER DROWSINESS VISUAL BEHAVIOUR AND MACHINE LEARNING MONITORING SYSTEM
DRIVER DROWSINESS VISUAL BEHAVIOUR AND MACHINE LEARNING MONITORING SYSTEM Open
Drowsy driving is one of the major causes of deaths occurring in road accidents.The truck drivers who drive for continuous long hours (especially at night), bus drivers of long-distance route or overnight buses are more susceptible to this…
View article: Speech Emotion Recognition
Speech Emotion Recognition Open
Emotions are the best way for people to communicate their thoughts and actions to others. The most important technology in the world today is the ability to recognize emotions from a single speaker's voice. The ability to recognize emotion…
View article: Deep Convolutional Neural Networks Detect no Morphological Differences Between Culture-Positive and Culture-Negative Infectious Keratitis Images
Deep Convolutional Neural Networks Detect no Morphological Differences Between Culture-Positive and Culture-Negative Infectious Keratitis Images Open
These deep learning models were not able to identify morphological differences between microbiologically positive and negative corneal ulcers. This finding suggests that similar artificial intelligence models trained to identify the causat…
View article: Outcomes of Pythium keratitis: A Meta-Analysis of Individual Patient Data
Outcomes of Pythium keratitis: A Meta-Analysis of Individual Patient Data Open
View article: Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India
Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India Open
View article: Outpatient human coronavirus associated conjunctivitis in India
Outpatient human coronavirus associated conjunctivitis in India Open
View article: S1.5c Proteomics in fungal keratitis research: a road map to personalized treatment
S1.5c Proteomics in fungal keratitis research: a road map to personalized treatment Open
S1.5 Mycotic Keratitis, September 21, 2022, 11:00 AM - 12:30 PM Research becomes very significant and meaningful when it addresses a significant public health problem of a region. Fungal keratitis, ulceration of the cornea due to fungal in…
View article: Antiamoebic Susceptibility in Acanthamoeba Keratitis: Comparison of Isolates From South India and Northern California
Antiamoebic Susceptibility in Acanthamoeba Keratitis: Comparison of Isolates From South India and Northern California Open
Purpose: Outcomes of Acanthamoeba keratitis are often worse in India than in the United States. The goal of this study was to determine whether antiamoebic susceptibility patterns were different when comparing Acanthamoeba isolates from In…
View article: Prevalence and Molecular Characterization of Metallo β-Lactamase Producing Gram-Negative Pathogens Causing Eye Infections
Prevalence and Molecular Characterization of Metallo β-Lactamase Producing Gram-Negative Pathogens Causing Eye Infections Open
Purpose: Metallo β-lactamases (MβL) production is a worldwide problem, particularly in gram-negative bacteria. As scanty data is available on the prevalence of MBL, the present study is being undertaken to determine the prevalence, antibac…
View article: Outcomes of amoebic, fungal, and bacterial keratitis: A retrospective cohort study
Outcomes of amoebic, fungal, and bacterial keratitis: A retrospective cohort study Open
Background Acanthamoeba keratitis is challenging to treat and thought to result in poor outcomes, but very few comparative studies exist to assess whether ulcers caused by Acanthamoeba are worse than those caused by bacteria or fungus. Met…
View article: Image-Based Differentiation of Bacterial and Fungal Keratitis Using Deep Convolutional Neural Networks
Image-Based Differentiation of Bacterial and Fungal Keratitis Using Deep Convolutional Neural Networks Open
Computer vision models achieved superhuman performance in identifying the underlying infectious cause of corneal ulcers compared with cornea specialists. The best-performing model, MobileNet, attained an AUC of 0.83 to 0.86 without any add…
View article: Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India
Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India Open
ClinicalTrials.gov Identifiers: NCT00996736 and NCT02570321.
View article: Expression of immune response genes in human corneal epithelial cells interacting with Aspergillus flavus conidia
Expression of immune response genes in human corneal epithelial cells interacting with Aspergillus flavus conidia Open
Background Aspergillus flavus , one of the causative agents of human fungal keratitis, can be phagocytosed by human corneal epithelial (HCE) cells and the conidia containing phagosomes mature into phagolysosomes. But the immunological resp…