Explanipedia

Paraquat Poisoning: A Case Series Open

Anju Shrestha, Hari Kumar Shrestha, Prakash Kafle, Parikshit Prasai, Rajendra Awasthi · 2025

Paraquat (PQ) poisoning remains a critical public health concern in Nepal due to its high mortality rate and absence of a specific antidote. PQ, first introduced in 1955 as a herbicide, is extremely toxic when ingested. This report present…

A Clinical Study on Chronic Subdural Hematoma and its Surgical Management at a Tertiary Care Hospital in the Eastern Part of Nepal Open

Sunil Singh, Prakash Kafle, Narendera Prashad Joshi, Aakash Kafle, Tejendra Karki · 2025

Background: Chronic subdural hematoma is a common neurosurgical condition, particularly in elderly patients, often associated with minor head trauma and requiring surgical intervention. This study aims to analyse the demographic patterns, …

Blood Glucose Level Prediction in Type 1 Diabetes Using Machine Learning Open

Shi-Jye Chu, Nalaka Amarasiri, Saroj Kumar Giri, Prakash Kafle · 2025

Type 1 Diabetes is a chronic autoimmune condition in which the immune system attacks and destroys insulin-producing beta cells in the pancreas, resulting in little to no insulin production. Insulin helps glucose in your blood enter your mu…

Recurrent Hemorrhagic Stroke in Bilateral Basal Ganglia: A Comprehensive Case Report of Sequential Events Open

Arjun Subedi, Prakash Kafle · 2024

Hemorrhagic strokes typically occur unilaterally, often in individuals with a history of hypertension. Bilateral recurrent hemorrhagic strokes are exceedingly rare and present significant clinical challenges in patient management. This cas…

Clinical Profile and Outcome of Twin Babies Delivered at a Tertiary Care Center in Eastern Nepal Open

Babita Khanal, Sunil Kumar Yadav, Prakash Kafle, Subash Bhattarai, Namrata KC , et al. · 2024

Introduction: Twin pregnancies are often associated with higher risks of complications for both the mother and the neonates, particularly in resource-limited settings. This study was conducted at a tertiary care center in Eastern Nepal to …

Clinical Characteristics and Outcome of Spontaneous Intracerebral Hemorrhage Open

Pramod Kumar Chaudhary, Prakash Kafle, Dipak Kumar Yadav, Narendera Prasad Joshi · 2024

Background: Stroke is the second leading cause of death and disability globally. Intracerebral hemorrhage represents a prominent subtype comprising 10-20% of all strokes and posing substantial challenges, particularly in low-income countri…

Dyke –Davidoff – Masson Syndrome in a 28 years old pregnant woman – A rare case report Open

Ashmita Yadav, Pramod Kumar Chaudhary, Prakash Kafle, Edmond Jonathan, Sabin Jung Shah · 2024

Dyke -Davidoff- Masson (DDM) Syndrome is rare neurological disorder commonly affecting the children but is rarely reported in adults as well. It mostly presents with seizure, hemiparesis followed by mental retardation and facial asymmetry.…

Diffusion Tensor Tractography in Patient with Cervical Spondylosis and Correlation with Clinical Findings Open

Mahesh Gautam, Robinson Shrestha, Nawaraj Ranabhat, Prakash Kafle, Bijay Shrestha , et al. · 2024

Introduction: Diffusion tensor imaging is a non-invasive advanced method that provides information on white matter microstructural integrity. Fractional anisotropy and apparent diffusion coefficient have been used to quantify the degree of…

Clinical Characteristics and Outcome of Patients With Intraoperative Aneurysm Rupture: A Retrospective Cohort Study From Nepal Open

Mohan Raj Sharma, Sandeep Bohara, Dipendra Kumar Shrestha, Deepak Raj Joshi, Shreejana Singh , et al. · 2024

BACKGROUND AND OBJECTIVES: Intraoperative aneurysm rupture (IAR) is a significant complication during microsurgical clipping of cerebral aneurysms. The timing of rupture during surgery, morphology of the aneurysm, and strategies to mitigat…

Impact of Tailored Intensive Rehabilitation on Functional Independence and Quality of Life in Brain Tumor Patients: A Prospective Observational Study Open

Narendera Prashad Joshi, Prakash Kafle, Babita Khanal, Dipak Yadav, Pramod Chaudhary , et al. · 2023

Background: Brain tumors are a heterogeneous group causing disability. They significantly impact functional independence and quality of life. This study aims to investigate how tailored intensive rehabilitation affects brain tumor patients…

Prevalence of Iron Deficiency Anemia among Under Five Years Children in a Tertiary Health Care Center of Nepal Open

Babita Khanal, Sandip Pokhrel, Sandip Kumar Singh, Sunil Kumar Yadav, Prakash Kafle · 2023

BackgroundGlobally 39.8% children under five years old are anemic, with prevalence of childhood anemia in Nepal reported to be 52.7% by 2016. The aim of this study is to analyze the prevalence of anemia among pediatric age group between 2 …

Pediatric Intensive Care Unit in a Developing Nation: Exploring Acute Neurological Illnesses and Their Clinical Course Open

Babita Khanal, Sandeep Kumar Singh, Rajnish Mishra, Prakash Kafle, Mohan Raj Sharma · 2023

Introduction: The burden of neurological illnesses is high in pediatric age group. Both primary neurological illnesses and neurological complication of systemic illness are commonly seen in pediatric intensive care unit (PICU). Neurologica…

Surgical treatment of Candida albicans spondylodiscitis Open

Prashant Adhıkarı, Nishma Pokharel, Sulochana Khadka, Ishwar Lohani, Prakash Kafle , et al. · 2023

Introduction: Spinal infection poses a demanding diagnostic and treatment problem for which a multidisciplinary approach with spine surgeons, radiologists, and infectious disease specialists is required. Infections are usually caused by ba…

Dr. Juha Hernesniemi, Visionary Neurosurgeon and Compassionate Healer Open

Prakash Kafle · 2023

Dr. Juha Hernesniemi, a visionary in the field of neurosurgery, passed away on June 27, 2023, at the age of 75. Born on May 3, 1948, in Helsinki, Finland, Dr. Hernesniemi dedicated his life to advancing the understanding and treatment of c…

Analysis of Neonatal Admission Patterns and Clinical Profiles in a Tertiary Care Center: Focus on Neonates Transferred from the Delivery Room to the Neonatal Intensive Care Unit Open

Babita Khanal, Sunil Kumar Yadav, Sandip Pokhrel, Sandip Kumar Singh, Gehanath Baral , et al. · 2023

Background: Neonatal mortality rate is very high in developing countries despite of advancement in perinatal and neonatal care with reduced neonatal mortality rate in many developed countries. This study aims to identify the reasons of adm…

Otogenic Brain Abscess in a Child of Third World Country - A Single Stage Transcranial Transmastoid Approach: A Case Report Open

Apar Adhikari, Tekendra Khanal, Rajesh Kumar Yadav, Bibek Ghimire, Meenakshi Basnet , et al. · 2023

Brain abscess, though not rare, is an uncommon complication of otitis media. We report a case of 12 years old male for chronic ear discharge, throbbing headache and post aural swelling for three weeks. A detailed history and physical exami…

Academic neurosurgery in Nepal: Present status and future directions Open

Mohan Raj Sharma, Gopal Sedain, Prakash Kafle, Amit Pradhanang, Shabal Sapkota , et al. · 2023

Concurrent Eloquent Area Bleeds in a Patient with Uncontrolled Hypertension Open

Bishomber Neupane, Ipsa Shakya, Rajiv Neupane, Babita Khanal, Prakash Kafle , et al. · 2022

Uncontrolled hypertension being the most important risk factor for intracerebral hemorrhage (ICH) often leads to solitary hematoma whereas multiple spontaneous simultaneous ICH is not common, and occurrence of bilateral hemorrhage is a rar…

Intraoperative Neuromonitoring in Predicting Neurological Deficits in Patients with Intramedullary Lesions in a Tertiary Care Center in Nepal Open

Binod Rajbhandari, Prakash Kafle, Amit Pradhanang, Gopal Sedain, Sushil K Shilpakar , et al. · 2022

Introduction: Intramedullary spinal cord lesions (IMSCL) constitute 20%–30% of all spinal cord lesions. There is still uncertainty regarding the usefulness of intraoperative neuromonitoring (IONM) during spinal surgery. The purpose of this…

Clinical and Radiological Profile and Early Outcome of Skull Base Surgeries in a Tertiary Care Center in Eastern Nepal Open

Prakash Kafle, Dipak Kumar Yadav, Babita Khanal, Narendra Prasad Joshi, Mohan Raj Sharma · 2022

Background: Surgery of the skull base is challenging due to its complex anatomy and relative inaccessibility. Surgical anatomy and approaches to the cranial base have been well described in the neurosurgical literature. Method: This is an …

Auto-Craniotomy With Leaves Implantation on the Surface of the Brain Following a Road Traffic Accident Open

Rajiv Neupane, Dipak Kumar Yadav, Samiksha A. Raut, Prakash Kafle · 2022

The development of modern vehicles that are not compatible with the roads, the rising burden of vehicles on narrow roads, and the recklessness of the vehicle's driver and pedestrians have resulted in an increase in uncommon and severe form…

Authors’ conflicts of interest in Nepalese healthcare journals Open

Mohan Raj Sharma, Subigya Parajuli, Lava Shrestha, Gopal Sedain, Prakash Kafle · 2022

Most biomedical journals now require authors to declare their conflicts of interest (COI), especially financial ones, before they accept the manuscript for submission. This study aims to examine the COI policies of Nepalese healthcare jour…

Reliability Analysis Techniques in Distribution System: A Comprehensive Review Open

Prakash Kafle, Manila Bhandari, Lalit Bickram Rana · 2022

Quality of electricity with continuity is the reliability of the power system which is inversely proportional with the duration of power supply interruption.It depends on some expected or unexpected faults/failures on the systems, speed of…

Spectrum of Central Nervous System Tumours at Tertiary Care Centre in Nepal Open

Pramod Chaudhary, Sunil Munakomi, Narendera Prashad Joshi, Babita Khanal, Prakash Kafle · 2022

IntroductionMost of the Central Nervous System tumors are benign. There is increase in the incidence in recent days which might be due to improved diagnosis with advancement in the ancillary studies. This study aims to provide a single cen…

Short Term Clinical Outcome of Micro Lumbar Discectomy in Tertiary Care Center Open

Pramod Chaudhary, Prakash Kafle, Narendera Prashad Joshi, U.S. Gautam · 2021

Background: Minimal invasive open lumbar microdiscectomy has been associated with good success rate and low morbidity. The present study is aimed to evaluate the clinical outcome of patients who underwent open minimal invasive open lumbar …

Outcome prediction in spontaneous intracerebral hemorrhage: A comparative study of ICH, WFNS, and GVS scoring systems Open

Binod Rajbhandari, Gopal Sedain, Dipendra Kumar Shrestha, Prakash Kafle, Amit Pradhanang , et al. · 2021

Introduction: A good predicting scoring system for intracerebral hemorrhage (ICH) has been a concern for decades, as this will help in guiding the treatment and prognostication. The most widely accepted one is the Hemphill ICH score, but t…

Surgical Management and Early Outcome of Encephalocele Open

Prakash Kafle, Mohan Raj Sharma, Sushil Krishna Shilpakar, Gopal Sedain, Amit Pradhanang , et al. · 2021

Background: There are limited studies pertaining to management of encephalocele in Nepal. So the present study seems justifiable to bridge the gap in the literature on encephalocele from Nepal on its clinical profile and early outcome. Thi…

CT Evaluation of Optic Nerve Sheath Diameter in Traumatic Brain Injury and its Correlation with Rotterdam CT Scoring Open

Mahesh Gautam, Prakash Kafle, Manish Raj Pathak, Ganesh Devkota, Nawaraj Ranabhat · 2020

Introduction: Elevated intracranial pressure is one of the fatal events associated with traumatic brain injury. Optic nerve sheath diameter measurement is an indirect way of assessing intracranial pressure. Optic nerve sheath diameter and …

Early Outcome of Surgery in Pediatric Head Injury: Experience From a Tertiary Care Center in Eastern Nepal Open

Babita Khanal, Prakash Kafle, Sandip Kumar Singh, Sunil Kumar Yadav, Bishomber Neupane , et al. · 2020

Introduction Head injuries among the pediatric age group remain an unwelcomed source of morbidity and mortality resulting from falls, motor vehicle accidents, assaults, and child abuse. Early identification and management of traumatic brai…

Early Outcome of Surgery in Pediatric Head Injury: Experience From a Tertiary Care Center in Eastern Nepal Open

Babita Khanal, Prakash Kafle, Sandip Kumar Singh, Sunil Kumar Yadav, Bishomber Neupane , et al. · 2020

Introduction: Head injuries among the pediatric age group remain an unwelcomed source of morbidity and mortality resulting from falls, motor vehicle accidents, assaults, and child abuse. Early identification and management of traumatic bra…

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