Prakash Nagarkatti
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View article: Delta-9-Tetrahydrocannabinol abrogates neurodegeneration by regulating microbial dysbiosis in transgenic mice expressing gp120 of HIV-1 2631
Delta-9-Tetrahydrocannabinol abrogates neurodegeneration by regulating microbial dysbiosis in transgenic mice expressing gp120 of HIV-1 2631 Open
Description AIDS patients develop HIV-associated neurocognitive disorders (HAND), believed to result from neuroinflammation. In this study, we examined the effect of Delta-9-Tetrahydrocannabinol (THC) in HIV gp120 transgenic (Tg) mice and …
View article: Aryl hydrocarbon receptor regulates kynurenine pathway enzymes in dendritic cells to modulate quinolinic acid and reduce depressive-like behavior during colitis 3333
Aryl hydrocarbon receptor regulates kynurenine pathway enzymes in dendritic cells to modulate quinolinic acid and reduce depressive-like behavior during colitis 3333 Open
Description Inflammatory bowel disease (IBD) is linked with increased incidence of major depressive disorder. Although mechanisms attributed to this gut-brain axis (GBA) observation remain unclear, destabilization of the gut-derived metabo…
View article: AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis
AhR‐Dependent Induction of β‐Defensin 1 in Colonic Epithelial Cells Regulates Cross‐Talk between Gut Microbiota and Immune Response Leading to Attenuation of Colitis Open
The aryl hydrocarbon receptor (AhR) acts as a critical signaling hub that connects immune cells, food and environmental cues, and microbiota to regulate intestinal homeostasis. In the current study, the role of AhR in the regulation of an …
View article: The aryl hydrocarbon receptor: a new frontier in male reproductive system
The aryl hydrocarbon receptor: a new frontier in male reproductive system Open
AhR is pivotal in male reproductive physiology, influencing spermatogenesis, sperm quality, and hormone regulation through its interactions with both endogenous and environmental ligands. Persistent pollutants such as dioxins and polycycli…
View article: AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis
AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis Open
Alpha-defensin 1 is a small antimicrobial peptide that acts as the first line of defense against pathogens. It is induced following microbial cues and inflammatory signals in neutrophils and Paneth cells in the small intestine, which sugge…
View article: Antimicrobial cobaltocenium copolymers: tuning amphiphilicity against NDM-1 bacteria
Antimicrobial cobaltocenium copolymers: tuning amphiphilicity against NDM-1 bacteria Open
Cationic metallopolymers offer a promising strategy to combat multidrug-resistant (MDR) Gram-negative bacteria.
View article: Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease
Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease Open
View article: Regulation of Bacteroides acidifaciens by the aryl hydrocarbon receptor in IL-22-producing immune cells has sex-dependent consequential impact on colitis
Regulation of Bacteroides acidifaciens by the aryl hydrocarbon receptor in IL-22-producing immune cells has sex-dependent consequential impact on colitis Open
Introduction Colitis is an inflammatory bowel disease (IBD) characterized by immune cell dysregulation and alterations in the gut microbiome. In our previous report, we showed a natural product in cruciferous vegetables and ligand of the a…
View article: Delta-9-Tetrahydrocannabinol Blocks Bone Marrow-Derived Macrophage Differentiation through Elimination of Reactive Oxygen Species
Delta-9-Tetrahydrocannabinol Blocks Bone Marrow-Derived Macrophage Differentiation through Elimination of Reactive Oxygen Species Open
Macrophages are vital components of the immune system and serve as the first line of defense against pathogens. Macrophage colony-stimulating factor (M-CSF) induces macrophage differentiation from bone marrow-derived cells (BMDCs). Δ9-tetr…
View article: Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency
Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency Open
Background Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation…
View article: Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs
Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs Open
Introduction Indole-3-carbinol (I3C) is found in cruciferous vegetables and used as a dietary supplement. It is known to act as a ligand for aryl hydrocarbon receptor (AhR). In the current study, we investigated the role of AhR and the abi…
View article: Identification of miRNAs that target Fcγ receptor-mediated phagocytosis during macrophage activation syndrome
Identification of miRNAs that target Fcγ receptor-mediated phagocytosis during macrophage activation syndrome Open
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile arthritis, accompanied by cytokine storm and hemophagocytosis. In addition, COVID-19–related hyperinflammation shares clinical features of MAS. Me…
View article: Editorial: Substance abuse and the microbiome
Editorial: Substance abuse and the microbiome Open
The gastrointestinal (GI) tract harbors a highly complex array of microorganisms that play a critical role in regulating homeostasis in the body. Thus, any perturbations or imbalance, termed dysbiosis, can trigger disease. While the direct…
View article: Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis
Aryl Hydrocarbon Receptor Regulates Muc2 Production Independently of IL-22 during Colitis Open
We previously reported that an aryl hydrocarbon receptor (AhR) ligand, indole-3-carbinol (I3C), was effective at reducing colitis severity through immune cell-mediated interleukin-22 (IL-22) production. Intestinal epithelial cells (IECs) a…
View article: Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency
Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency Open
Background Primary immunodeficiencies are heritable defects in immune system function. Antibody deficiency is the most common form of primary immunodeficiency in humans, can be caused by abnormalities in both the development and activation…
View article: B-cell-specific MhcII regulates microbiota composition in a primarily IgA-independent manner
B-cell-specific MhcII regulates microbiota composition in a primarily IgA-independent manner Open
Background The expression of major histocompatibility complex class II ( MhcII ) molecules on B cells is required for the development of germinal centers (GCs) in lymphoid follicles; the primary sites for the generation of T-cell-dependent…
View article: Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis
Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis Open
Introduction Endometriosis is a painful disease that affects around 5% of women of reproductive age. In endometriosis, ectopic endometrial cells or seeded endometrial debris grow in abnormal locations including the peritoneal cavity. Commo…
View article: Membrane‐Active Metallopolymers: Repurposing and Rehabilitating Antibiotics to Gram‐Negative Superbugs (Adv. Healthcare Mater. 31/2023)
Membrane‐Active Metallopolymers: Repurposing and Rehabilitating Antibiotics to Gram‐Negative Superbugs (Adv. Healthcare Mater. 31/2023) Open
Antimicrobial Resistance Two hands, representing either cationic cobaltocenium moieties (adjuvants) or antibiotics, hold together to achieve synergy between adjuvants and antibiotics, with the goal of enhancing antibiotic efficacy to disru…
View article: Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions
Resveratrol Attenuates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Induction of Myeloid-Derived Suppressor Cells (MDSC) and Their Functions Open
Previously, we showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor (AhR) ligand and a potent and persistent toxicant and carcinogenic agent, induces high levels of murine myeloid-derived suppressor cell (MD…
View article: Effect of TCDD exposure in adult female and male mice on the expression of miRNA in the ovaries and testes and associated reproductive functions
Effect of TCDD exposure in adult female and male mice on the expression of miRNA in the ovaries and testes and associated reproductive functions Open
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant found widely across the world. While animal and human studies have shown that exposure to TCDD may cause significant alterations in the reproductive tract, the effe…
View article: Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms
Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms Open
View article: Membrane‐Active Metallopolymers: Repurposing and Rehabilitating Antibiotics to Gram‐Negative Superbugs
Membrane‐Active Metallopolymers: Repurposing and Rehabilitating Antibiotics to Gram‐Negative Superbugs Open
Among multiple approaches to combating antimicrobial resistance, a combination therapy of existing antibiotics with bacterial membrane‐perturbing agents is promising. A viable platform of metallopolymers as adjuvants in combination with tr…
View article: Facially Amphiphilic Bile Acid-Functionalized Antimicrobials: Combating Pathogenic Bacteria, Fungi, and Their Biofilms
Facially Amphiphilic Bile Acid-Functionalized Antimicrobials: Combating Pathogenic Bacteria, Fungi, and Their Biofilms Open
We report facially amphiphilic bile acid-based antimicrobials with a broad spectrum of activity against both bacterial and fungal pathogens and negligible detrimental effects on mammalian cells. Two lead compounds eliminated dormant subpop…
View article: The impact of geographic inequality in federal research funding: A comparative longitudinal study of research and scholarly outputs in EPSCoR versus non-EPSCoR states
The impact of geographic inequality in federal research funding: A comparative longitudinal study of research and scholarly outputs in EPSCoR versus non-EPSCoR states Open
Some states in the U.S. have traditionally received less federal research funding than other states. The National Science Foundation (NSF) created a program in 1979, called the Experimental Program to Stimulate Competitive Research (EPSCoR…
View article: Characterization of Chemotaxis-Associated Gene Dysregulation in Myeloid Cell Populations in the Lungs during Lipopolysaccharide-Mediated Acute Lung Injury
Characterization of Chemotaxis-Associated Gene Dysregulation in Myeloid Cell Populations in the Lungs during Lipopolysaccharide-Mediated Acute Lung Injury Open
During endotoxin-induced acute lung injury (ALI), immune cell recruitment resulting from chemotaxis is mediated by CXC and CC chemokines and their receptors. In this study, we investigated the role of chemokines and their receptors in the …
View article: Indol-3-Carbinol ameliorates colitis in mice by AhR-mediated production of antimicrobial peptides and mucins
Indol-3-Carbinol ameliorates colitis in mice by AhR-mediated production of antimicrobial peptides and mucins Open
Indole-3-carbinol (I3C) is a dietary compound that acts as a ligand for the aryl hydrocarbon receptor (AhR), an important sensor for environmental polyaromatic chemicals and a regulator of the immune response. The pathogenesis of colitis i…
View article: Characterization of gene alterations during Macrophage Activation Syndrome associated with central nervous system disorders
Characterization of gene alterations during Macrophage Activation Syndrome associated with central nervous system disorders Open
Macrophage activation syndrome (MAS) is the immense proinflammatory condition that occurs most frequently in patients with systemic juvenile idiopathic arthritis (SJIA) and systemic lupus erythematosus (SLE). An important feature of MAS is…
View article: Role of CCR2 in Staphylococcus Enterotoxin B-induced Acute Respiratory Distress Syndrome
Role of CCR2 in Staphylococcus Enterotoxin B-induced Acute Respiratory Distress Syndrome Open
Acute Respiratory Distress Syndrome (ARDS) is a fatal condition in which damage to the lungs results in fluid buildup and eventually hypoxia. Elucidating the immunological mechanism of this disorder is vital for reducing fatality. Staphylo…
View article: B cells regulate luminal bile acid composition in the small intestine
B cells regulate luminal bile acid composition in the small intestine Open
Recent studies have demonstrated that bile acids (BA) influence immune cell homeostasis in the gut. However, whether and how, the host immune response can influence BA biochemistry is unknown. This is an important question to answer becaus…
View article: Role of Bacteroides <i>acidifaciens</i> in gut inflammation during colitis
Role of Bacteroides <i>acidifaciens</i> in gut inflammation during colitis Open
Colitis is an inflammatory bowel disease characterized by chronic inflammation of the colon with significant disease-associated alterations in the gut microbiome, a term known as microbial dysbiosis. IBDs, are becoming more prevalent in in…