Prakashkumar Dobariya
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View article: Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue
Inhibition of the angiotensin-converting enzyme N-terminal catalytic domain prevents endogenous opioid degradation in brain tissue Open
Natural opioid signals in the brain produced by Met-enkephalin-Arg-Phe are enhanced after blocking its degradation by the N-terminal catalytic domain of angiotensin-converting enzyme.
View article: Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling
Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling Open
Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin hept…
View article: The Yin-Yang of sulfur dioxide: Effect on cognitive function
The Yin-Yang of sulfur dioxide: Effect on cognitive function Open
Gaseous neurotransmitters drive numerous physiological processes, rendering important their study in pathophysiology. One such gasotransmitter, sulfur dioxide (SO2), is abundantly produced by the cardiovascular system. SO2 influences hemod…
View article: Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling
Exploiting the Angiotensin-Converting Enzyme Pathway to Augment Endogenous Opioid Signaling Open
Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin hept…
View article: Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice
Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice Open
Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is ess…
View article: Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase
Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase Open
The endogenous opioid system regulates pain through local release of neuropeptides and modulation of their action on opioid receptors. However, the effect of opioid peptides, the enkephalins, is short-lived due to their rapid hydrolysis by…
View article: Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice
Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice Open
Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC) has a narrow therapeutic window and early treatment is essent…
View article: Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease Open
3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-m…