Pramod Kumar Pal
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View article: Accuracy of CSF Tap Test and Lumbar Infusion Test in Predicting Shunt Response in Idiopathic Normal Pressure Hydrocephalus: A Systematic Review and Meta-Analysis
Accuracy of CSF Tap Test and Lumbar Infusion Test in Predicting Shunt Response in Idiopathic Normal Pressure Hydrocephalus: A Systematic Review and Meta-Analysis Open
Background Idiopathic normal pressure hydrocephalus (iNPH) presents with gait disturbance, cognitive impairment, and urinary incontinence. The cerebrospinal fluid tap test (CSF-TT) and lumbar infusion test (LIT) are commonly used to predic…
View article: Pre-motor Mesenchymal stromal Cell Dysfunction Drives Immune Dysregulation in Parkinson’s Disease
Pre-motor Mesenchymal stromal Cell Dysfunction Drives Immune Dysregulation in Parkinson’s Disease Open
Parkinson's disease (PD) is characterized by chronic neuroinflammation and peripheral immune dysfunction, yet the mechanisms underlying systemic-immunomodulatory failure remain unclear. Here we demonstrate that mesenchymal stromal cell (MS…
View article: Whole-genome sequencing of 197 cases with Parkinson’s Disease reveals novel pathogenic variants in the Indian population
Whole-genome sequencing of 197 cases with Parkinson’s Disease reveals novel pathogenic variants in the Indian population Open
Background Most genetic studies of Parkinson’s disease (PD) have been performed in European cohorts, and large-scale studies in Indian populations are lacking. Consequently, many variants common in Europeans are rare or absent in Indian pa…
View article: Barriers and Facilitators to Advance Care Planning Implementation for Patients with Neurodegenerative Diseases among Indian Physicians: A Mixed-Methods Analysis
Barriers and Facilitators to Advance Care Planning Implementation for Patients with Neurodegenerative Diseases among Indian Physicians: A Mixed-Methods Analysis Open
Background Advance care planning (ACP) is a process that enables individuals to define and communicate their goals and preferences for future medical care, which is especially important in chronic progressive illnesses, such as Parkinson’s…
View article: EyeMap: A fusion-based method for eye movement-based visual attention maps as predictive markers of parkinsonism
EyeMap: A fusion-based method for eye movement-based visual attention maps as predictive markers of parkinsonism Open
EyeMap is a method for visualizing and classifying eye movement patterns using scanpaths, fixation heatmaps, and gridded Areas of Interest (AOIs). EyeMap combines predictions from modality-specific machine learning and deep learning models…
View article: Diagnostic Accuracy of CSF Tap-Test Parameters in Predicting Shunt Responsiveness in Normal Pressure Hydrocephalus: A Cohort Study
Diagnostic Accuracy of CSF Tap-Test Parameters in Predicting Shunt Responsiveness in Normal Pressure Hydrocephalus: A Cohort Study Open
Background The cerebrospinal fluid tap test (CSF-TT) is widely used as an ancillary test to select patients with idiopathic Normal Pressure Hydrocephalus (iNPH) for surgical management; however, its diagnostic utility remains unclear. We e…
View article: CSF Tap Test Parameters and Short-Term Outcomes in operated and non-operated patients with idiopathic Normal Pressure Hydrocephalus: A Cohort Study
CSF Tap Test Parameters and Short-Term Outcomes in operated and non-operated patients with idiopathic Normal Pressure Hydrocephalus: A Cohort Study Open
Background Normal Pressure hydrocephalus (NPH) is treated by ventriculoperitoneal shunting. The cerebrospinal fluid tap test (CSF-TT) is widely used to identify candidates for shunt surgery in idiopathic NPH (iNPH). This study aimed to com…
View article: Revisiting the Triglyceride–Glucose Index in Parkinson’s Disease: Risk Ractor or Disease Marker?
Revisiting the Triglyceride–Glucose Index in Parkinson’s Disease: Risk Ractor or Disease Marker? Open
View article: Clinical profile and Genetic Composition of patients with Juvenile Parkinsonism from a single tertiary care center in India
Clinical profile and Genetic Composition of patients with Juvenile Parkinsonism from a single tertiary care center in India Open
More than two-thirds (67.5%) of the juvenile parkinsonism patients in our cohort had an underlying monogenetic cause. PARK-PRKN, PARK-PLA2G6, and PARK-SYNJ1 are the common causes of genetically mediated juvenile parkinsonism in India.
View article: Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease
Association of Bassoon (BSN) Gene Mutations with Gait and Motor Impairments in Parkinson's Disease Open
Introduction Parkinson's Disease (PD) features debilitating motor symptoms, particularly gait and balance impairments inadequately managed by current therapies. Bassoon (BSN), a presynaptic active zone organizer, has been implicated in var…
View article: Anti-IgLON5-Related Movement Disorders: A Series of Three Cases from a Tertiary Centre in India
Anti-IgLON5-Related Movement Disorders: A Series of Three Cases from a Tertiary Centre in India Open
View article: Rescue Right Pallidotomy and Left Thalamotomy in a patient with <i>PLA2G6</i> -associated Refractory Status Dystonicus and Tremor
Rescue Right Pallidotomy and Left Thalamotomy in a patient with <i>PLA2G6</i> -associated Refractory Status Dystonicus and Tremor Open
View article: Predictors of Impulse Control Disorders in Patients with Parkinson’s Disease
Predictors of Impulse Control Disorders in Patients with Parkinson’s Disease Open
View article: Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study
Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study Open
Background Parkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors. Objectives The aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO)…
View article: A Comparative Analysis of Different MRI Sequences Dedicated for Invivo Detection of Mineralization in a Single Large Cohort of Progressive Supranuclear Palsy and Healthy Controls
A Comparative Analysis of Different MRI Sequences Dedicated for Invivo Detection of Mineralization in a Single Large Cohort of Progressive Supranuclear Palsy and Healthy Controls Open
Iron plays an important role in normal brain metabolism. Increase in brain iron is a part of the normal brain development, but an excessive deposition of brain iron may be a risk factor for degenerative diseases. At the clinical setting, t…
View article: Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population
Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population Open
Background Atypical Parkinsonian Syndromes (APS) form the third largest group of neurodegenerative disorders including Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA), and Corticobasal Syndrome (CBS). These conditions a…
View article: Movement Disorders in CSF1R-Related Leukoencephalopathy: A Case Series
Movement Disorders in CSF1R-Related Leukoencephalopathy: A Case Series Open
CSF1R -related leukoencephalopathy is a rare, dominantly inherited leukoencephalopathy caused by mutations in the CSF1R gene that codes for colony-stimulating factor 1 receptor. We describe the clinical and neuroimaging features in three g…
View article: Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice
Fibrinogen and Complement Factor H Induce Parkinsonian and Cognitive Impairment-Like Features in Mice Open
Cognitive impairment is one of the non-motor symptoms of Parkinson's disease (PD), which may precede motor impairment. Biomarker(s) can help detect the cognitive dysfunction, much earlier in the disease and may differentiate PD patients wi…
View article: A comprehensive review on assessing paan (Piper betle’s) efficacy in diabetes management under environmental stress
A comprehensive review on assessing paan (Piper betle’s) efficacy in diabetes management under environmental stress Open
View article: Neurophysiology of Atypical Parkinsonian Syndromes: A Study Group Position Paper
Neurophysiology of Atypical Parkinsonian Syndromes: A Study Group Position Paper Open
Atypical parkinsonian syndromes (APs) are characterized by parkinsonian features combined with additional motor and non‐motor signs and symptoms. Neurophysiological studies have contributed to clarifying differences and similarities betwee…
View article: Diagnostic Spectrum in an “Atypical” Atypical Parkinsonism Syndrome Cohort: A Single Center Experience
Diagnostic Spectrum in an “Atypical” Atypical Parkinsonism Syndrome Cohort: A Single Center Experience Open
View article: The Burden of Rheumatic Chorea in the Modern Era: A Case Series From a Tertiary Health Care Center in South India
The Burden of Rheumatic Chorea in the Modern Era: A Case Series From a Tertiary Health Care Center in South India Open
View article: Altered Cortical Excitability and Inhibition in Patients with Primary Dystonia: A Transcranial Magnetic Stimulation Study
Altered Cortical Excitability and Inhibition in Patients with Primary Dystonia: A Transcranial Magnetic Stimulation Study Open
Background: The literature on cortical excitability, inhibitory and facilitatory properties of the brain in patients with primary dystonia is not well elucidated. We aimed to study the changes in these neurophysiological parameters in pati…
View article: Deep Learning–Based Artificial Intelligence Algorithm to Classify Tremors from Hand‐Drawn Spirals
Deep Learning–Based Artificial Intelligence Algorithm to Classify Tremors from Hand‐Drawn Spirals Open
Background No objective biomarkers exist for diagnosing and classifying tremor syndromes. Objective The aim was to develop and validate a deep learning (DL) algorithm for classifying tremors from hand‐drawn pen‐on‐paper spirals. Methods We…
View article: Allelic Diversity, de novo CAG Expansions, and Intergenerational Instability at the HTT Locus in a clinical sample of Huntington’s Disease from India
Allelic Diversity, de novo CAG Expansions, and Intergenerational Instability at the HTT Locus in a clinical sample of Huntington’s Disease from India Open
BACKGROUND Huntington’s disease (HD) is an inherited, neurodegenerative disorder, caused by the expansion of an unstable CAG repeat sequence in the HTT gene. The prevalence of HD, allelic diversity, rate of novel expansions, and the clinic…
View article: Deciphering the Genetic Architecture of Parkinson’s Disease in India
Deciphering the Genetic Architecture of Parkinson’s Disease in India Open
The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability in PD has been studied predominantly in European populati…
View article: A Rare Case of Bilateral Ovarian Adult Granulosa Cell Tumors Associated with Uterine Lipoleiomyoma- Case Report and Review of Literature
A Rare Case of Bilateral Ovarian Adult Granulosa Cell Tumors Associated with Uterine Lipoleiomyoma- Case Report and Review of Literature Open
Leiomyomas are the most common uterine tumors and uterine lipoleiomyoma is a rare variant. Lipomatous tumors of the uterus includes spectrum of lesions comprising of lipomas, lipoleiomyoma, angiomyolipomas and fibrolipomyomas in the benign…
View article: Current Practice Patterns Among Indian Neurologists in the Evaluation and Management of Normal Pressure Hydrocephalus: A Nationwide Cross-Sectional Survey
Current Practice Patterns Among Indian Neurologists in the Evaluation and Management of Normal Pressure Hydrocephalus: A Nationwide Cross-Sectional Survey Open
View article: Body Composition and Resting Metabolic Rate in Parkinson's Disease a Prospective Cross-Sectional Single Centre Study
Body Composition and Resting Metabolic Rate in Parkinson's Disease a Prospective Cross-Sectional Single Centre Study Open
View article: Current Management of Neurological Wilson’s Disease
Current Management of Neurological Wilson’s Disease Open
Wilson's disease (WD) is a disorder of copper metabolism due to variants in the ATP7B gene. This autosomal recessively inherited disorder is characterized by the accumulation of copper in various body parts, mainly the liver, brain,…