Pranay Sinha
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View article: Integrated Stability and Metabolomic Investigation of New Rifampicin and Isoniazid co-loaded Liposome against Tuberculosis
Integrated Stability and Metabolomic Investigation of New Rifampicin and Isoniazid co-loaded Liposome against Tuberculosis Open
This study aimed to develop and evaluate rifampicin (RIF) and isoniazid (INH) co-loaded liposome for sustained drug delivery to enhance therapeutic efficacy against tuberculosis (TB) and overcome challenges associated with prolonged treatm…
View article: Metabolite dynamics over the course of anti-tuberculosis treatment in individuals with mild and severe tuberculosis
Metabolite dynamics over the course of anti-tuberculosis treatment in individuals with mild and severe tuberculosis Open
Mycobacterium tuberculosis (Mtb) manipulates host metabolism to gain nutrients and increase virulence. Despite known alterations in metabolism in individuals with pulmonary tuberculosis (PTB) during anti-tuberculosis (TB) treatment, the ef…
View article: TB stigma in India: A narrative review of types of stigma, gender differences, and potential interventions
TB stigma in India: A narrative review of types of stigma, gender differences, and potential interventions Open
In India, persons with tuberculosis (PWTB) and their households experience significant disease-related stigma. The objective of this narrative review was to conduct a review of existing literature related to the types of stigma experienced…
View article: Taxes for tuberculosis: could tobacco and sugar tax revenue fund tuberculosis control interventions?
Taxes for tuberculosis: could tobacco and sugar tax revenue fund tuberculosis control interventions? Open
View article: Temperature-driven shifts in haematology and erythrocyte morphology of Nile tilapia Oreochromis niloticus
Temperature-driven shifts in haematology and erythrocyte morphology of Nile tilapia Oreochromis niloticus Open
View article: Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study
Global, regional, and national estimates of tuberculosis incidence averted by eliminating undernutrition in adults: a modelling study Open
Background Current efforts to reduce global tuberculosis incidence have proved insufficient, highlighting that urgent action is needed to address underlying modifiable risk factors such as undernutrition. We aimed to estimate the global im…
View article: In-kind Nutritional Supplementation for Persons With Drug-susceptible Tuberculosis and Their Household Contacts Would be Cost-effective for Reducing Tuberculosis Incidence and Mortality in Jharkhand, India: A Modeling Study
In-kind Nutritional Supplementation for Persons With Drug-susceptible Tuberculosis and Their Household Contacts Would be Cost-effective for Reducing Tuberculosis Incidence and Mortality in Jharkhand, India: A Modeling Study Open
Background Undernutrition is the leading cause of tuberculosis (TB) globally, but nutritional interventions are often considered cost-prohibitive. The RATIONS study demonstrated that nutritional supplementation to household contacts of per…
View article: Energy dense nutritional supplements improve weight gain among malnourished adults with drug-sensitive pulmonary tuberculosis: an open-label randomized controlled trial in Faridabad, India
Energy dense nutritional supplements improve weight gain among malnourished adults with drug-sensitive pulmonary tuberculosis: an open-label randomized controlled trial in Faridabad, India Open
This open-label randomized controlled trial in India assessed the impact of a peanut-based energy-dense nutritional supplement (EDNS) on weight gain among undernourished adults with drug-susceptible pulmonary tuberculosis in India. EDNS si…
View article: Modelling the effect of a nutritional shock on tuberculosis in India
Modelling the effect of a nutritional shock on tuberculosis in India Open
Background Environmental or social changes and shocks that reduce access to adequate nutrition have potential consequences for tuberculosis (TB), as undernutrition is a major driver of TB incidence and poor TB treatment outcomes. Methods W…
View article: Social Vulnerability Modifies the Effects of Geographic Proximity on Engagement in Latent Tuberculosis Infection Care in a United States Safety Net Healthcare Network
Social Vulnerability Modifies the Effects of Geographic Proximity on Engagement in Latent Tuberculosis Infection Care in a United States Safety Net Healthcare Network Open
Background Latent tuberculosis (TB) infection care often requires engagement with multiple teams in several locations throughout the diagnostic and treatment steps of the TB infection care cascade. The intersecting effects of geographic pr…
View article: Comparing Active Case-Finding Strategies and Passive Case-Finding for Tuberculosis: An Umbrella Review of Current Evidence
Comparing Active Case-Finding Strategies and Passive Case-Finding for Tuberculosis: An Umbrella Review of Current Evidence Open
Background Tuberculosis (TB) remains a global health challenge. Recent studies have compared active case-finding (ACF) with passive case-finding (PCF) and various ACF strategies, assessing diagnostic yield, treatment outcomes, cost-effecti…
View article: Food insecurity in South Indian households with TB during COVID-19 lockdowns and the impact of nutritional interventions: A qualitative study
Food insecurity in South Indian households with TB during COVID-19 lockdowns and the impact of nutritional interventions: A qualitative study Open
Tuberculosis (TB) mortality rose during the COVID-19 pandemic, as did food insecurity worldwide. Undernourished individuals are at increased risk for incident TB disease and TB mortality. This study examines the impact of COVID lockdowns o…
View article: A roadmap for integrating nutritional assessment, counselling, and support into the care of people with tuberculosis
A roadmap for integrating nutritional assessment, counselling, and support into the care of people with tuberculosis Open
Undernutrition-the leading risk factor for tuberculosis worldwide-is associated with impaired immunity, more extensive disease, delayed sputum conversion, and worse treatment outcomes, including mortality. In this Health Policy, we propose…
View article: Enriching tuberculosis research by measuring poverty better: a perspective
Enriching tuberculosis research by measuring poverty better: a perspective Open
View article: Impact of Nutritional Support for Tuberculosis on Intermediate and Terminal Undernutrition and Treatment Outcomes (INSTITUT) study: a protocol for a quasi-experimental study to assess the impact of nutritional support on tuberculosis treatment outcomes in Benin and Togo
Impact of Nutritional Support for Tuberculosis on Intermediate and Terminal Undernutrition and Treatment Outcomes (INSTITUT) study: a protocol for a quasi-experimental study to assess the impact of nutritional support on tuberculosis treatment outcomes in Benin and Togo Open
Introduction Undernourished persons with tuberculosis (TB) (PWTB) are at increased risk of mortality, treatment failure and relapse. Nutritional support for PWTB has the potential to mitigate the risk of undernutrition. However, given ethi…
View article: P-786. Rates of Treatment Discontinuation over Time with Rifampin versus Isoniazid for Latent Tuberculosis Infection: A 6-year Experience at a Large Safety-Net Clinic
P-786. Rates of Treatment Discontinuation over Time with Rifampin versus Isoniazid for Latent Tuberculosis Infection: A 6-year Experience at a Large Safety-Net Clinic Open
Background Treatment of latent tuberculosis infection (LTBI) is a crucial component of tuberculosis (TB) eradication plans in the United States (US). It is estimated that 80% of active TB cases arise from LTBI reactivation. Numerous gaps h…
View article: Estimating the epidemiological and economic impact of providing nutritional care for tuberculosis-affected households across India: a modelling study
Estimating the epidemiological and economic impact of providing nutritional care for tuberculosis-affected households across India: a modelling study Open
View article: Cost-Effectiveness of In-Kind Nutritional Support for Impoverished Persons with Tuberculosis to Reduce Mortality and Disengagement from Care in India: A Modeling Study
Cost-Effectiveness of In-Kind Nutritional Support for Impoverished Persons with Tuberculosis to Reduce Mortality and Disengagement from Care in India: A Modeling Study Open
View article: Dimension Independent and Computationally Efficient Shadow Tomography
Dimension Independent and Computationally Efficient Shadow Tomography Open
We describe a new shadow tomography algorithm that uses $n=Θ(\sqrt{m}\log m/ε^2)$ samples, for $m$ measurements and additive error $ε$, which is independent of the dimension of the quantum state being learned. This stands in contrast to al…
View article: NP-hardness of testing equivalence to sparse polynomials and to constant-support polynomials
NP-hardness of testing equivalence to sparse polynomials and to constant-support polynomials Open
An $s$-sparse polynomial has at most $s$ monomials with nonzero coefficients. The Equivalence Testing problem for sparse polynomials (ETsparse) asks to decide if a given polynomial $f$ is equivalent to (i.e., in the orbit of) some $s$-spar…
View article: Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India
Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India Open
In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-mont…
View article: Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection—a Multicenter Prospective Cohort Analysis
Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection—a Multicenter Prospective Cohort Analysis Open
Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infectio…
View article: Food Insecurity and Undernutrition Are Associated With Distinct Immunologic Profiles in People With Tuberculosis and Advanced HIV Starting Antiretroviral Therapy
Food Insecurity and Undernutrition Are Associated With Distinct Immunologic Profiles in People With Tuberculosis and Advanced HIV Starting Antiretroviral Therapy Open
Background: Food insecurity and undernutrition are related but distinct concepts contributing to poor HIV and tuberculosis outcomes. Pathways linking them with immunologic profile, which may relate to clinical outcomes, remain understudied…
View article: Nutritionally acquired immunodeficiency must be addressed with the same urgency as HIV to end tuberculosis
Nutritionally acquired immunodeficiency must be addressed with the same urgency as HIV to end tuberculosis Open
View article: In-Kind Nutritional Supplementation for Household Contacts of Persons with Tuberculosis Would Be Cost-Effective for Reducing Tuberculosis Incidence and Mortality in India: A Modeling Study
In-Kind Nutritional Supplementation for Household Contacts of Persons with Tuberculosis Would Be Cost-Effective for Reducing Tuberculosis Incidence and Mortality in India: A Modeling Study Open
View article: In-kind nutritional supplementation for household contacts of persons with tuberculosis would be cost-effective for reducing tuberculosis incidence and mortality in India: a modeling study
In-kind nutritional supplementation for household contacts of persons with tuberculosis would be cost-effective for reducing tuberculosis incidence and mortality in India: a modeling study Open
Background Undernutrition is the leading cause of tuberculosis (TB) globally, but nutritional interventions are often considered cost prohibitive. The RATIONS study demonstrated that nutritional support provided to household contacts of pe…
View article: Estimating the Epidemiological and Economic Impact of Providing Nutritional Care for Tuberculosis-Affected Households Across India
Estimating the Epidemiological and Economic Impact of Providing Nutritional Care for Tuberculosis-Affected Households Across India Open
View article: National Institutes of Health Funding for Tuberculosis Comorbidities Is Disproportionate to Their Epidemiologic Impact
National Institutes of Health Funding for Tuberculosis Comorbidities Is Disproportionate to Their Epidemiologic Impact Open
Tuberculosis (TB) is a leading infectious killer worldwide. We systematically searched the National Institutes of Health Research, Portfolio Online Reporting Tools Expenditures and Results (RePORTER) website to compare research funding for…
View article: Analysis of the Cross-Study Replicability of Tuberculosis Gene Signatures Using 49 Curated Transcriptomic Datasets
Analysis of the Cross-Study Replicability of Tuberculosis Gene Signatures Using 49 Curated Transcriptomic Datasets Open
Background Tuberculosis (TB) is the leading cause of infectious disease mortality worldwide. Numerous blood-based gene expression signatures have been proposed in the literature as alternative tools for diagnosing TB infection. Ongoing eff…
View article: 1898. Optimizing selection of latent TB management strategies among immigrants from high TB burden settings to the United States
1898. Optimizing selection of latent TB management strategies among immigrants from high TB burden settings to the United States Open
Background Treatment for latent tuberculosis infection (LTBI) with rifampin and isoniazid is very effective but carries significant hepatotoxicity risks, increasing with age. Further, since the risk of progression to tuberculosis (TB) dise…