Explanipedia

White matter lesion effect modification of aspirin and unfractionated heparin during endovascular stroke treatment Open

Laura M. van Poppel, Lucas de Vries, Mahsa Mojtahedi, Henk van Voorst, Praneeta R. Konduri , et al. · 2025

Objectives Periprocedural aspirin or unfractionated heparin during endovascular treatment in acute ischemic stroke increases symptomatic intracranial hemorrhage (sICH) risk without improving functional outcome. White matter lesions (WMLs) …

Deep generative models for vessel segmentation in CT angiography of the brain Open

Henk van Voorst, Jiahang Su, Praneeta R. Konduri, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos , et al. · 2025

Automated vessel segmentation in brain CT angiography (CTA) remains challenging despite the potential benefit of applications. Expert acquisition of reference vessel segmentations is a laborious task. We propose an unsupervised generative …

Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy Open

Anne van der Meij, Ghislaine Holswilder, Marie Louise E. Bernsen, Hendrikus JA van Os, Jeannette Hofmeijer , et al. · 2024

Introduction: To improve our understanding of the relatively poor outcome after endovascular treatment (EVT) in women we assessed possible sex differences in baseline neuroimaging characteristics of acute ischemic stroke patients with larg…

Impact of Intracranial Volume and Brain Volume on the Prognostic Value of Computed Tomography Perfusion Core Volume in Acute Ischemic Stroke Open

Jan W. Hoving, Praneeta R. Konduri, Manon L. Tolhuisen, Miou S. Koopman, Henk van Voorst , et al. · 2024

Background: Computed tomography perfusion (CTP)-estimated core volume is associated with functional outcomes in acute ischemic stroke. This relationship might differ among patients, depending on brain volume. Materials and Methods: We retr…

Value of Automatically Derived Full Thrombus Characteristics: An Explorative Study of Their Associations with Outcomes in Ischemic Stroke Patients Open

Mahsa Mojtahedi, Agnetha A.E. Bruggeman, Henk van Voorst, Елена Пономарева, Manon Kappelhof , et al. · 2024

(1) Background: For acute ischemic strokes caused by large vessel occlusion, manually assessed thrombus volume and perviousness have been associated with treatment outcomes. However, the manual assessment of these characteristics is time-c…

Author Correction: A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions Open

Rémy Petkantchin, Alexandre Rousseau, Omer Eker, Karim Zouaoui Boudjeltia, Franck Raynaud , et al. · 2023

Abstract 249: In‐silico Versus In‐Vitro Evaluation of a New Stent‐Retriever Design: A Novel Approach to Pre‐clinical Development Open

Sara Bridio, Praneeta R. Konduri, Shashvat M. Desai, Nerea Arrarte Terreros, Giulia Luraghi , et al. · 2023

Introduction In‐vitro evaluation (analysis in a bench top flow model) is the gold standard and a regulatory requirement for pre‐clinical investigation of devices being developed for endovascular thrombectomy (EVT). In‐silico evaluation (co…

Generation of a Virtual Cohort of Patients for in Silico Trials of Acute Ischemic Stroke Treatments Open

Sara Bridio, Giulia Luraghi, Anna Ramella, José Félix Rodríguez Matas, Gabriele Dubini , et al. · 2023

The development of in silico trials based on high-fidelity simulations of clinical procedures requires the availability of large cohorts of three-dimensional (3D) patient-specific anatomy models, which are often hard to collect due to limi…

A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions Open

Rémy Petkantchin, Alexandre Rousseau, Omer Eker, Karim Zouaoui Boudjeltia, Franck Raynaud , et al. · 2023

One of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a biochemical product into the patient’s bloodstream, which breaks down the thrombi’s fibrin fibers: intravenous or intravascular thrombolysis. Howeve…

Role of intravenous alteplase on late lesion growth and clinical outcome after stroke treatment Open

Praneeta R. Konduri, Fabiano Cavalcante, Henk van Voorst, Leon A. Rinkel, Manon Kappelhof , et al. · 2023

Several acute ischemic stroke mechanisms that cause lesion growth continue after treatment which is detrimental to long-term clinical outcome. The potential role of intravenous alteplase treatment (IVT), a standard in stroke care, in cessi…

Microcatheter tracking in thrombectomy procedures: A finite-element simulation study Open

Nerea Arrarte Terreros, Silvia Renon, Francesca Zucchelli, Sara Bridio, José Félix Rodríguez Matas , et al. · 2023

Prognostic Value of Thrombus Volume and Interaction With First-Line Endovascular Treatment Device Choice Open

Henk van Voorst, Agnetha A.E. Bruggeman, Jurr O. Andriessen, Jan W. Hoving, Praneeta R. Konduri , et al. · 2023

Background: A larger thrombus in patients with acute ischemic stroke might result in more complex endovascular treatment procedures, resulting in poorer patient outcomes. Current evidence on thrombus volume and length related to procedural…

Infarct Evolution in Patients with Anterior Circulation Large-Vessel Occlusion Randomized to IV Alteplase and Endovascular Treatment versus Endovascular Treatment Alone Open

Jan W. Hoving, Henk van Voorst, Manon Kappelhof, Manon L. Tolhuisen, Kilian M. Treurniet , et al. · 2023

No statistically significant difference in infarct evolution was found in directly admitted patients who received IV alteplase and endovascular treatment within 4.5 hours of symptom onset versus patients who underwent endovascular treatmen…

Prognostic Value of Combined Radiomic Features from Follow-Up DWI and T2-FLAIR in Acute Ischemic Stroke Open

Alessia Gerbasi, Praneeta R. Konduri, Manon L. Tolhuisen, Fabiano Cavalcante, Leon A. Rinkel , et al. · 2022

The biological pathways involved in lesion formation after an acute ischemic stroke (AIS) are poorly understood. Despite successful reperfusion treatment, up to two thirds of patients with large vessel occlusion remain functionally depende…

In silico thrombectomy trials for acute ischemic stroke Open

Claire Miller, Praneeta R. Konduri, Sara Bridio, Giulia Luraghi, Nerea Arrarte Terreros , et al. · 2022

Risk factors of late lesion growth after acute ischemic stroke treatment Open

Praneeta R. Konduri, Amber Bucker, Anna M.M. Boers, Bruna Garbugio Dutra, Noor Samuels , et al. · 2022

Background Even days after treatment of acute ischemic stroke due to a large vessel occlusion, the infarct lesion continues to grow. This late, subacute growth is associated with unfavorable functional outcome. In this study, we aim to ide…

Unsupervised Deep Learning for Stroke Lesion Segmentation on Follow-up CT Based on Generative Adversarial Networks Open

Henk van Voorst, Praneeta R. Konduri, Laura M. van Poppel, Wouter van der Steen, P Matthijs van der Sluijs , et al. · 2022

An unsupervised generative adversarial network can be used to obtain automated infarct lesion segmentations with a moderate Dice similarity coefficient and good volumetric correspondence.

Thrombus radiomics in patients with anterior circulation acute ischemic stroke undergoing endovascular treatment Open

Henk van Voorst, Agnetha A.E. Bruggeman, Wenjin Yang, Jurr O. Andriessen, Elise Welberg , et al. · 2022

Background Thrombus radiomics (TR) describe complex shape and textural thrombus imaging features. We aimed to study the relationship of TR extracted from non-contrast CT with procedural and functional outcome in endovascular-treated patien…

Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence Open

Nerea Arrarte Terreros, Agnetha A.E. Bruggeman, Manon Kappelhof, Manon L. Tolhuisen, Josje Brouwer , et al. · 2022

Background The effects of thrombus imaging characteristics on procedural and clinical outcomes after ischemic stroke are increasingly being studied. These thrombus characteristics – for eg, size, location, and density – are commonly analyz…

Association of thrombus density and endovascular treatment outcomes in patients with acute ischemic stroke due to M1 occlusions Open

Agnetha A.E. Bruggeman, Nyk Aberson, Manon Kappelhof, Bruna Garbugio Dutra, Jan W. Hoving , et al. · 2022

Bifurcation occlusions and endovascular treatment outcome in acute ischemic stroke Open

Nerea Arrarte Terreros, Agnetha A.E. Bruggeman, Henk van Voorst, Praneeta R. Konduri, Ivo G.H. Jansen , et al. · 2022

Background A thrombus in the M1 segment of the middle cerebral artery (MCA) can occlude this main stem only or extend into the M1-M2 bifurcation. The occlusion pattern may affect endovascular treatment (EVT) success, as a bifurcated thromb…

Fully Automated Thrombus Segmentation on CT Images of Patients with Acute Ischemic Stroke Open

Mahsa Mojtahedi, Manon Kappelhof, Елена Пономарева, Manon L. Tolhuisen, Ivo G.H. Jansen , et al. · 2022

Thrombus imaging characteristics are associated with treatment success and functional outcomes in stroke patients. However, assessing these characteristics based on manual annotations is labor intensive and subject to observer bias. Theref…

Virtual Patient-Specific Thrombectomies: The Impact of the Vessel Morphology Open

Sara Bridio, Giulia Luraghi, José Félix Rodríguez Matas, Julia N. Kawamoto, Kevin M. Moerman , et al. · 2022

Development of a patient-specific cerebral vasculature fluid–structure-interaction model Open

Kevin M. Moerman, Praneeta R. Konduri, Behrooz Fereidoonnezhad, Henk A. Marquering, Aad van der Lugt , et al. · 2022

Automated Final Lesion Segmentation in Posterior Circulation Acute Ischemic Stroke Using Deep Learning Open

Riaan Zoetmulder, Praneeta R. Konduri, Iris V. Obdeijn, Efstratios Gavves, Ivana Išgum , et al. · 2021

Final lesion volume (FLV) is a surrogate outcome measure in anterior circulation stroke (ACS). In posterior circulation stroke (PCS), this relation is plausibly understudied due to a lack of methods that automatically quantify FLV. The app…

Quantitative 3D analysis of tissue damage in a rat model of microembolization Open

Theodosia Georgakopoulou, Anne‐Eva van der Wijk, Erik N.T.P. Bakker, Ed VanBavel, Charles B.L.M. Majoie , et al. · 2021

Impact of the Internal Carotid Artery Morphology on in silico Stent-Retriever Thrombectomy Outcome Open

Sara Bridio, Giulia Luraghi, José Félix Rodríguez Matas, Gabriele Dubini, Giorgia G. Giassi , et al. · 2021

The aim of this work is to propose a methodology for identifying relationships between morphological features of the cerebral vasculature and the outcome of in silico simulations of thrombectomy, the mechanical treatment for acute ischemic…

Posttreatment Ischemic Lesion Evolution Is Associated With Reduced Favorable Functional Outcome in Patients With Stroke Open

Praneeta R. Konduri, Henk van Voorst, Amber Bucker, Katinka van Kranendonk, Anna M.M. Boers , et al. · 2021

Background and Purpose: Ischemic lesion volume can increase even 24 hours after onset of an acute ischemic stroke. In this study, we investigated the association of lesion evolution with functional outcome and the influence of successful r…

The Role of Edema in Subacute Lesion Progression After Treatment of Acute Ischemic Stroke Open

Praneeta R. Konduri, Katinka van Kranendonk, Anna M.M. Boers, Kilian M. Treurniet, Olvert A. Berkhemer , et al. · 2021

Background: Ischemic lesions commonly continue to progress even days after treatment, and this lesion growth is associated with unfavorable functional outcome in acute ischemic stroke patients. The aim of this study is to elucidate the rol…

The first virtual patient-specific thrombectomy procedure Open

Giulia Luraghi, Sara Bridio, José Félix Rodríguez Matas, Gabriele Dubini, Nikki Boodt , et al. · 2021

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