Prasad Devarajan
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View article: Development and Validation of Multiplex Assays for Lupus Nephritis Activity Biomarkers
Development and Validation of Multiplex Assays for Lupus Nephritis Activity Biomarkers Open
View article: Cleome spinosa Jacq. (Cleomaceae)- An addition to the flora of Tamil Nadu
Cleome spinosa Jacq. (Cleomaceae)- An addition to the flora of Tamil Nadu Open
View article: Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts
Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts Open
View article: Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts
Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts Open
Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue remo…
View article: Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis
Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis Open
Introduction Early and accurate diagnosis of urinary tract infection (UTI) can prevent serious sequelae including chronic kidney disease. Multiple individual studies have identified urine neutrophil gelatinase-associated lipocalin (uNGAL) …
View article: Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts
Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts Open
Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue remo…
View article: Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome
Plasma renin as a novel prognostic biomarker of sepsis-associated acute respiratory distress syndrome Open
View article: Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis
Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis Open
Examining kidney fibrosis is crucial for mechanistic understanding and developing targeted strategies against chronic kidney disease (CKD). Persistent fibroblast activation and tubular epithelial cell (TEC) injury are key CKD contributors.…
View article: Efficacy and Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis-A Double-Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study).
Efficacy and Safety of Pharmacokinetically-Driven Dosing of Mycophenolate Mofetil for the Treatment of Pediatric Proliferative Lupus Nephritis-A Double-Blind Placebo Controlled Clinical Trial (The Pediatric Lupus Nephritis Mycophenolate Mofetil Study). Open
The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) study will provide a thorough evaluation of the PK of MMF in pediatric LN patients, yielding a head-to-head comparison of MMFBSA and MMFPK for both safety an…
View article: Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury
Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury Open
Acute kidney injury (AKI) is a major risk factor for long-term adverse outcomes, including chronic kidney disease. In mouse models of AKI, maladaptive repair of the injured proximal tubule (PT) prevents complete tissue recovery. However, e…
View article: Pediatric AKI in the real world: changing outcomes through education and advocacy—a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Pediatric AKI in the real world: changing outcomes through education and advocacy—a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference Open
View article: Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference Open
View article: Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference Open
View article: Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference
Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference Open
View article: Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference
Advances in pediatric acute kidney injury pathobiology: a report from the 26th Acute Disease Quality Initiative (ADQI) conference Open
View article: External Validation of a Urinary Biomarker Risk Score for the Prediction of Steroid Responsiveness in Adults With Nephrotic Syndrome
External Validation of a Urinary Biomarker Risk Score for the Prediction of Steroid Responsiveness in Adults With Nephrotic Syndrome Open
View article: A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children: a report from the 26th Acute Disease Quality Initiative (ADQI) conference
A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children: a report from the 26th Acute Disease Quality Initiative (ADQI) conference Open
Acute kidney injury (AKI) in children is associated with increased morbidity, reduced health-related quality of life, greater resource utilization, and higher mortality. Improvements in the timeliness and precision of AKI diagnosis in chil…
View article: Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study
Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study Open
View article: Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis
Single-cell sequencing dissects the transcriptional identity of activated fibroblasts and identifies novel persistent distal tubular injury patterns in kidney fibrosis Open
Examining kidney fibrosis is crucial for mechanistic understanding and developing targeted strategies against chronic kidney disease (CKD). Persistent fibroblast activation and tubular epithelial cell (TEC) injury are key CKD contributors.…
View article: Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network
Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulonephropathy Network Open
View article: Pathogenesis of intrinsic acute kidney injury
Pathogenesis of intrinsic acute kidney injury Open
Purpose of review This review focuses on the pathogenesis of intrinsic acute kidney injury (AKI), emphasizing recent advances that hold therapeutic promise. Recent findings Enhanced endothelin and reduced endothelium-derived nitric oxide r…
View article: 1115 RAIL biomarkers capture response to induction therapy in pediatric patients during induction therapy
1115 RAIL biomarkers capture response to induction therapy in pediatric patients during induction therapy Open
Background Systemic Lupus Erythematosus (SLE) remains a diagnostic and therapeutic challenge, particularly lupus nephritis (LN). We previously described a composite score, the pediatric Renal Activity Index for Lupus (pRAIL), consisting of…
View article: 1106 Stability of novel urinary biomarkers used for lupus
1106 Stability of novel urinary biomarkers used for lupus Open
Background We have developed and validated the Renal Activity Index for Lupus (RAIL), a composite score of six urinary biomarkers including neutrophil gelatinase – associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1/CCL2…
View article: Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease
Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease Open
View article: Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children
Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children Open
Importance Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in children and young adults and is associated with poor short-term and long-term outcomes. Guidance is required to focus efforts related to expansio…
View article: PO.5.97 The renal activity index for lupus (RAIL) identifies active renal disease in SLE patients and its longitudinal score associates with renal responses in lupus nephritis
PO.5.97 The renal activity index for lupus (RAIL) identifies active renal disease in SLE patients and its longitudinal score associates with renal responses in lupus nephritis Open
Purpose Lupus nephritis (LN) confers poor prognosis, and there is a lack of effective non-invasive tests to assess disease activity and treatment response. We previously showed that a set of six urinary biomarkers (NGAL, KIM-1, MCP-1, adip…
View article: Single-cell transcriptomic profiling of kidney fibrosis identifies a novel specific fibroblast marker and putative disease target
Single-cell transcriptomic profiling of kidney fibrosis identifies a novel specific fibroblast marker and putative disease target Open
Background Persistent kidney fibroblast activation and tubular epithelial cell (TEC) injury are key contributors to CKD. However, transcriptional and cellular identities of advanced kidney disease, along with renal fibroblast specific mark…
View article: Olfactomedin 4 as a novel loop of <scp>Henle‐specific</scp> acute kidney injury biomarker
Olfactomedin 4 as a novel loop of <span>Henle‐specific</span> acute kidney injury biomarker Open
Acute kidney injury (AKI) is associated with morbidity and mortality. Urinary biomarkers may disentangle its clinical heterogeneity. Olfactomedin 4 (OLFM4) is a secreted glycoprotein expressed in stressed neutrophils and epithelial cells. …
View article: Stability of novel urinary biomarkers used for lupus nephritis
Stability of novel urinary biomarkers used for lupus nephritis Open
Background The Renal Activity Index for Lupus (RAIL) is a composite score of six urinary biomarkers (neutrophil gelatinase–associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), cerulopla…
View article: Human Stem Cell and Organoid Models to Advance Acute Kidney Injury Diagnostics and Therapeutics
Human Stem Cell and Organoid Models to Advance Acute Kidney Injury Diagnostics and Therapeutics Open
Acute kidney injury (AKI) is an increasingly common problem afflicting all ages, occurring in over 20% of non-critically ill hospitalized patients and >30% of children and >50% of adults in critical care units. AKI is associated with serio…