Prasant Kumar Jena
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View article: Activation of NLRP3 inflammasome in neutrophils promotes cardiovascular lesions in a mouse model of Kawasaki Disease 4448
Activation of NLRP3 inflammasome in neutrophils promotes cardiovascular lesions in a mouse model of Kawasaki Disease 4448 Open
Description Kawasaki Disease (KD) is a febrile systemic vasculitis and the leading cause of acquired heart diseases in children. Intravenous immunoglobulin (IVIG) treatment reduces the incidence of coronary artery aneurysms (CAAs), which o…
View article: Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy
Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy Open
BACKGROUND Sirtuin 1 (SIRT1), a NAD + -dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 activation, and promoting the clearance of damaged mitochondria. However, its preci…
View article: Redundant role of PAD2 and PAD4 in the development of cardiovascular lesions in a mouse model of Kawasaki disease vasculitis
Redundant role of PAD2 and PAD4 in the development of cardiovascular lesions in a mouse model of Kawasaki disease vasculitis Open
Kawasaki disease (KD) is the leading cause of acquired heart disease in children. While circulating neutrophils are increased and activated during acute KD, it is unclear whether neutrophils and neutrophil extracellular traps (NETs) contri…
View article: The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice
The intestinal microbiota contributes to the development of immune-mediated cardiovascular inflammation and vasculitis in mice Open
SUMMARY Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD), an acute pediatric vasculitis, remains unclear. We report th…
View article: Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice
Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice Open
Deletion of the nuclear hormone receptor small heterodimer partner (Shp) ameliorates the development of obesity and nonalcoholic steatohepatitis (NASH) in mice. Liver-specific SHP plays a significant role in this amelioration. The gut micr…
View article: Editorial: Targeting gut microbiota modulation by dietary supplementation to improve metabolic diseases
Editorial: Targeting gut microbiota modulation by dietary supplementation to improve metabolic diseases Open
EDITORIAL article Front. Microbiol., 14 August 2023Sec. Food Microbiology Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1260520
View article: IL-33 promotes cardiovascular lesions development in a mouse model of Kawasaki Disease
IL-33 promotes cardiovascular lesions development in a mouse model of Kawasaki Disease Open
Kawasaki Disease (KD), a pediatric acute febrile illness and systemic vasculitis, is the leading cause of acquired heart diseases in children. Coronary artery aneurysms (CAAs) occur in up to 25% of untreated children, which is reduced to 5…
View article: The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study
The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study Open
Background Aging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver diseases that progress into cancer as they age, which is accelerated by Western diet (WD) …
View article: Retinoic Acid Signaling Is Compromised in DSS-Induced Dysbiosis
Retinoic Acid Signaling Is Compromised in DSS-Induced Dysbiosis Open
Obesity and malnutrition both cause dysbiosis and dampen retinoic acid (RA) signaling pathways, which play pivotal roles in biological processes. The current study evaluates a hypothesis that colitis-associated dysbiosis also has systemic …
View article: Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline
Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline Open
It has been shown that the Western diet (WD) induces systemic inflammation and cognitive decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced hepatic inflammation. The current study examines whether sha…
View article: Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy Open
We studied whether probiotics were beneficial for hormonal change-associated dysbiosis, which may influence the enteric nervous system and GI function during early pregnancy. The study was 16 days consisting of two cycles of six daily prob…
View article: Gut microbiome responses in the metabolism of human dietary components: Implications in health and homeostasis
Gut microbiome responses in the metabolism of human dietary components: Implications in health and homeostasis Open
The gut microbiome and its link with human health and disease have gained a lot of attention recently. The microbiome executes its functions in the host by carrying out the transformation of dietary components and/or de novo synthesis of v…
View article: Age-specific microbiota in altering host inflammatory and metabolic signaling as well as metabolome based on the sex
Age-specific microbiota in altering host inflammatory and metabolic signaling as well as metabolome based on the sex Open
Aging systemically affected inflammatory and metabolic signaling based on the sex. Gut microbiome is age and sex-specific, which affects inflammation and metabolism in a sex-dependent manner.
View article: Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting
Gut microbiome dysbiosis and correlation with blood biomarkers in active-tuberculosis in endemic setting Open
Tuberculosis (TB) is the largest infectious disease with 10 million new active-TB patients and1.7 million deaths per year. Active-TB is an inflammatory disease and is increasingly viewed as an imbalance of immune responses to M . tb . infe…
View article: Dysregulated bile acid receptor-mediated signaling and IL-17A induction are implicated in diet-associated hepatic health and cognitive function
Dysregulated bile acid receptor-mediated signaling and IL-17A induction are implicated in diet-associated hepatic health and cognitive function Open
Background Chronic consumption of high sugar and high fat diet associated with liver inflammation and cognitive decline. This paper tests a hypothesis that the development and resolution of diet-induced nonalcoholic fatty liver disease (NA…
View article: Dysregulated Bile Acid Receptor-mediated Signaling and IL-17A Induction are Implicated in Diet-associated Hepatic Health and Cognitive Function
Dysregulated Bile Acid Receptor-mediated Signaling and IL-17A Induction are Implicated in Diet-associated Hepatic Health and Cognitive Function Open
Background: Chronic consumption of high sugar and high fat diet associated with liver inflammation and cognitive decline. This paper tests a hypothesis that the development and resolution of diet-induced nonalcoholic fatty liver disease (N…
View article: Long-term effects of western diet consumption in male and female mice
Long-term effects of western diet consumption in male and female mice Open
Long-term consumption of a diet with excessive fat and sucrose (Western diet, WD) leads to an elevated risk of obesity and metabolic syndrome in both males and females. However, there are sexual dimorphisms in metabolism which are apparent…
View article: Dysregulated Bile Acid Receptor-mediated Signaling and IL-17A Induction are Implicated in Diet-associated Hepatic Health and Cognitive Function
Dysregulated Bile Acid Receptor-mediated Signaling and IL-17A Induction are Implicated in Diet-associated Hepatic Health and Cognitive Function Open
Background: Chronic consumption of high sugar and high fat diet associated with liver inflammation and cognitive decline. This paper tests a hypothesis that the development and resolution of diet-induced nonalcoholic fatty liver disease (N…
View article: Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model
Probiotics VSL#3 are effective in reversing non-alcoholic steatohepatitis in a mouse model Open
VSL#3 is useful in reversing NASH that occurred due to dysregulated BA synthesis and dysbiosis, suggesting its potential in liver cancer prevention.
View article: Obesity treatment by epigallocatechin‐3‐gallate−regulated bile acid signaling and its enriched <i>Akkermansia muciniphila</i>
Obesity treatment by epigallocatechin‐3‐gallate−regulated bile acid signaling and its enriched <i>Akkermansia muciniphila</i> Open
Dysregulated bile acid (BA) synthesis is accompanied by dysbiosis, leading to compromised metabolism. This study analyzes the effect of epigallocatechin‐3‐gallate (EGCG) on diet‐induced obesity through regulation of BA signaling and gut mi…
View article: Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced neuroplasticity
Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced neuroplasticity Open
The goal of this study was to identify the intrinsic links that explain the effect of a Western diet (WD) on cognitive dysfunction. Specific pathogen‐free, wild‐type mice were fed either a control diet (CD) or a high‐fat, high‐sucrose WD a…