Prashant Chandrasekaran
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View article: A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development
A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development Open
The heart and lung co-orchestrate their development during organogenesis. The mesoderm surrounding both the developing heart and anterior foregut endoderm provides instructive cues guiding cardiopulmonary development. Additionally, it serv…
View article: Dynamic behavior and lineage plasticity of the pulmonary venous endothelium
Dynamic behavior and lineage plasticity of the pulmonary venous endothelium Open
View article: A Spatiotemporal Cell Atlas of Cardiopulmonary Progenitor Cell Allocation During Development
A Spatiotemporal Cell Atlas of Cardiopulmonary Progenitor Cell Allocation During Development Open
View article: Rapid specialization and stiffening of the primitive matrix in developing articular cartilage and meniscus
Rapid specialization and stiffening of the primitive matrix in developing articular cartilage and meniscus Open
View article: Endodermal BRD4 mediates epithelial-mesenchymal crosstalk during lung development
Endodermal BRD4 mediates epithelial-mesenchymal crosstalk during lung development Open
SUMMARY Lung morphogenesis relies on diverse cell intrinsic and extrinsic mechanisms to ensure proper cellular differentiation and compartmentalization. Using genetic mouse models, tissue explants, and transcriptomic analysis, we demonstra…
View article: CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth
CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth Open
There is a growing amount of data uncovering the cellular diversity of the pulmonary circulation and mechanisms governing vascular repair after injury. However, the molecular and cellular mechanisms contributing to the morphogenesis and gr…
View article: Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features
Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features Open
View article: A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth
A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth Open
In adults, there is a growing amount of data uncovering the cellular diversity of the pulmonary circulation and mechanisms governing vascular repair after injury, however, molecular and cellular mechanisms contributing to the morphogenesis…
View article: Molecular Engineering of Pericellular Microniche <i>via</i> Biomimetic Proteoglycans Modulates Cell Mechanobiology
Molecular Engineering of Pericellular Microniche <i>via</i> Biomimetic Proteoglycans Modulates Cell Mechanobiology Open
Molecular engineering of biological tissues using synthetic mimics of native matrix molecules can modulate the mechanical properties of the cellular microenvironment through physical interactions with existing matrix molecules, and in turn…
View article: Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid
Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid Open
View article: In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease
In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease Open
View article: Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis
Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis Open
View article: Decorin regulates cartilage pericellular matrix micromechanobiology
Decorin regulates cartilage pericellular matrix micromechanobiology Open
View article: Roles of Type V collagen in the Joint Development and Osteoarthritis of Temporomandibular Joint
Roles of Type V collagen in the Joint Development and Osteoarthritis of Temporomandibular Joint Open
Temporomandibular joint (TMJ) disorders, or TMD, refers to a group of clinical disorders that affect the TMJ and its associated structures. TMJ Osteoarthritis (TMJ OA) is a major subtype of TMDs, which affects 10-16% of the population exhi…
View article: Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis
Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis Open
View article: Cyclophilin B control of lysine post-translational modifications of skin type I collagen
Cyclophilin B control of lysine post-translational modifications of skin type I collagen Open
Covalent intermolecular cross-linking of collagen is essential for tissue stability. Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (…