Explanipedia

Anti‐fibrotic effects of lisinopril (ACE inhibitor) and fasudil (ROCK inhibitor) in combination for canine corneal fibrosis in vitro Open

Brayden L. Routh, Ratnakar Tripathi, Elizabeth A. Giuliano, Payton Lujin, Prashant R. Sinha , et al. · 2024

Background Corneal fibrosis is a leading cause of blindness in mammalian species and may result in compromised performance in sports and daily functions. This study evaluated the safety and anti‐fibrotic effects of the FDA‐approved drugs, …

Analysis of Smad3 in the modulation of stromal extracellular matrix proteins in corneal scarring after alkali injury. Open

Suneel Gupta, Eric Zhang, Shweta Sinha, Lynn M. Martin, Tomy Varghese , et al. · 2024

The significant changes in profibrotic genes and stromal ECM proteins revealed a direct role of Smad3 in stromal ECM proteins and TGFβ/Smad-driven wound healing. Smad3 appears to be an attractive molecular target for limiting abnormal stro…

Toxicological effects of ocular acrolein exposure to eyelids in rabbits in vivo Open

Suneel Gupta, Lynn M. Martin, Eric Zhang, Prashant R. Sinha, James Landreneau , et al. · 2023

Characterization of C-X-C chemokine receptor type 5 in the cornea and role in the inflammatory response after corneal injury Open

Praveen Kumar Balne, Suneel Gupta, Keele M. Landon, Nishant R. Sinha, Alexandria Hofmann , et al. · 2022

Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure Open

Nishant R. Sinha, Ratnakar Tripathi, Praveen Kumar Balne, Sydney L. Green, Prashant R. Sinha , et al. · 2022

Corneal fibrosis abrogation by a localized AAV-mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo Open

Suneel Gupta, Michael Fink, Duraisamy Kempuraj, Nishant R. Sinha, Lynn Martin , et al. · 2022

Corneal fibrosis abrogation by a localized AAV-mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo Open

Suneel Gupta, Michael K Fink, Duraisamy Kempuraj, Nishant R. Sinha, Lynn M. Martin , et al. · 2022

Effects of Regular/Dilute Proparacaine Anesthetic Eye Drops in Combination with Ophthalmic Antibiotics on Corneal Wound Healing Open

Eric Zhang, Suneel Gupta, Evan Olson, Prashant R. Sinha, Nathan P. Hesemann , et al. · 2022

Purpose: Topical, local anesthetic eye drops in conjunction with antibiotics are commonly used to reduce ocular pain and treat patients in emergency clinics; however, their effects on corneal healing are poorly understood. Th…

Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo Open

Suneel Gupta, Filiz Buyank, Nihant R. Sinha, DeAna G. Grant, Prashant R. Sinha , et al. · 2022

Six-Month In Vivo Safety Profiling of Topical Ocular AAV5–Decorin Gene Transfer Open

Rajiv R. Mohan, Praveen Kumar Balne, Maryam S. Muayad, Ratnakar Tripathi, Nishant R. Sinha , et al. · 2021

AAV5-Dcn gene therapy has the potential to treat corneal fibrosis and neovascularization in vivo safely without significant ocular toxicity.

Long-Term Safety and Tolerability of BMP7 and HGF Gene Overexpression in Rabbit Cornea Open

Suneel Gupta, Nishant R. Sinha, Lynn M. Martin, Landon M. Keele, Prashant R. Sinha , et al. · 2021

Nanoparticle-mediated BMP7+HGF combination gene therapy has the potential to treat corneal fibrosis in vivo without short- or long-term toxicity.

Long-term tolerability profiling of BMP7+HGF overexpression on rabbit cornea in vivo Open

Rajiv R. Mohan, Suneel Gupta, Nishant R. Sinha, Lynn M. Martin, Nathan P. Hesemann , et al. · 2021

Effects of mustard gas exposure to the corneal basement membrane and epithelial-stromal attachment to human cornea ex vivo Open

Ratnakar Tripathi, Nishant R. Sinha, Praveen Kumar Balne, Suneel Gupta, Nathan P. Hesemann , et al. · 2021

Cellular and molecular changes in human corneal fibroblasts following hydrogen sulfide exposure in vitro Open

Praveen Kumar Balne, Nishant R. Sinha, Alexandria Hofmann, Ratnakar Tripathi, Suneel Gupta , et al. · 2021

The functional role of decorin in corneal neovascularization in vivo Open

Praveen Kumar Balne, Suneel Gupta, Jinjin Zhang, Daniel E. Bristow, Matthew Faubion , et al. · 2021

Glutathione is a potential therapeutic target for acrolein toxicity in the cornea Open

Suneel Gupta, Sabeeh Kamil, Prashant R. Sinha, Jason T. Rodier, Shyam S. Chaurasia , et al. · 2021

A Novel Topical Ophthalmic Formulation to Mitigate Acute Mustard Gas Keratopathy In Vivo: A Pilot Study Open

Ratnakar Tripathi, Praveen Kumar Balne, Nishant R. Sinha, Lynn M. Martin, Sabeeh Kamil , et al. · 2020

TED is effective against MGK.

A rabbit model for evaluating ocular damage from acrolein toxicity in vivo Open

Suneel Gupta, Michael K Fink, Lynn M. Martin, Prashant R. Sinha, Jason T. Rodier , et al. · 2020

Acrolein is a highly reactive and volatile unsaturated aldehyde commonly used for producing scores of commercial products. It has been recognized as a chemical weapon since its use during World War I, and more recently, in Syria. Acrolein …

SIRT1: A novel target to regulate corneal myofibroblast formation Open

Ratnakar Tripathi, Lynn M. Martin, Sabeeh Kamil, Nishant R. Sinha, Alexandria Hofmann , et al. · 2020

Comparative analysis of generic and brand NSAIDS toxicity in human corneal stromal fibroblasts Open

Mikayla Fraunfelder, Ratnakar Tripathi, Sabeeh Kamil, Sydney Green, Lynn M. Martin , et al. · 2020

Role of Smad3 in healing cornea using knockout (Smad3-/-) mice Open

Sydney Green, Suneel Gupta, Prashant R. Sinha, Nishant R. Sinha, Praveen Kumar Balne , et al. · 2020

Remarkable inhibition of corneal scarring by Id3 gene therapy in a preclinical rabbit in vivo model Open

Suneel Gupta, Prashant R. Sinha, Sabeeh Kamil, Nishant R. Sinha, Ratnakar Tripathi , et al. · 2020

Investigation of effects of decorin on stromal fibrillogenesis in adult un-injured and injured healing cornea using decorin knockout and wild type mice Open

Sabeeh Kamil, Suneel Gupta, Lynn M. Martin, Ratnakar Tripathi, Nathan P. Hesemann , et al. · 2020

Corneal stromal fibroblast-myofibroblast-fibroblast regulation via gene silencing Open

Praveen Kumar Balne, Ratnakar Tripathi, Suneel Gupta, Sabeeh Kamil, Prashant R. Sinha , et al. · 2020

Safety Profiling of AAV5-Id3 gene therapy using rabbits Open

Prashant R. Sinha, Suneel Gupta, Sabeeh Kamil, Nishant R. Sinha, Praveen Kumar Balne , et al. · 2020

Role of inhibitor of differentiation 3 gene in cellular differentiation of human corneal stromal fibroblasts. Open

Suneel Gupta, Lynn M. Martin, Nishant R. Sinha, Kaitlin E Smith, Prashant R. Sinha , et al. · 2020

Id3 regulates TGFβ-driven differentiation of h-CSFs and formation of h-CMFs in vitro. Targeted Id3 gene delivery has potential to treat corneal fibrosis and reestablish corneal clarity in vivo.

soft-matter/trackpy: Trackpy v0.4.2 Open

Dan Allan, Casper van der Wel, Nathan C. Keim, Thomas A Caswell, Devin Wieker , et al. · 2019

This is a minor release with two major new features: parallel processing to speed up feature-finding, and a new method for locating features in bright-field microscopy. There is also an overhaul of the walkthrough and other tutorials, and …

MyoD gene silencing promotes corneal fibroblast de-differentiation and reverses fibrosis Open

Rajiv R. Mohan, Ratnakar Tripathi, Praveen Kumar Balne, Suneel Gupta, Jason T. Rodier , et al. · 2019

GCLC nanomedicine for mitigation of Acrolein toxicity in the cornea Open

Prashant R. Sinha, Suneel Gupta, Praveen Kumar Balne, Ratnakar Tripathi, Elizabeth A. Giuliano , et al. · 2019

A phytochemical, Emodin, attenuates corneal stromal fibroblast differentiation and fibrosis Open

Sally Heil, Ratnakar Tripathi, Praveen Kumar Balne, Lynn M. Martin, Suneel Gupta , et al. · 2019

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