Explanipedia

Systematic metabolite screening identifies functional regulators of the adenosine A2A receptor Open

Prashant Rao, Manoj K Rathinaswamy, Michelle Chan, Ana Paredes, Chirag H. Patel , et al. · 2025

The adenosine A2A receptor (A2AR) is a Class A G protein-coupled receptor (GPCR) that regulates inflammation, glucose metabolism, and energy homeostasis in metabolically active tissues. While the effects of small-molecule ligands and prote…

Generation of Conformation‐Specific Monoclonal Antibodies for Integral Membrane Proteins Open

Natalie Sheldon, Gunasekaran Dhandapani, Junhoe Kim, Cathy J. Spangler, Chengli Fang , et al. · 2025

Antibodies and their antigen‐binding fragments, including fragment antigen‐binding domains (Fabs) and single‐chain variable fragments (scFvs), are extraordinary tools in all fields of biology, particularly in neuroscience, where they have …

A Novel Hybrid Resampling Approach for Analyzing Immune Thrombocytopenia Open

Arun Kumar, Prashant Rao · 2025

A Platelet Variability Index (PVI), reflecting both platelet count fluctuations and thrombocytopenia severity, distinguishes immune thrombocytopenia (ITP) from other thrombocytopenic causes (Na Li et al, 2021). Higher PVI scores correlated…

Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans Open

Usman A. Tahir, Jacob L. Barber, Daniel E. Cruz, Meltem Ece Kars, Shuliang Deng , et al. · 2024

BACKGROUNDMost GWAS of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry-enriched protein quantitative loci (pQTL).METHODSWe conducted a discovery GWAS of approximatel…

Purification and biochemical analysis of native AMPA receptors from three different mammalian species Open

Prashant Rao, Eric Gouaux · 2023

The majority of fast, excitatory synaptic transmission in the central nervous system (CNS) is mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), which are glutamate-activated ion channels integral to synap…

Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis Open

Héléne T. Cronjé, Michael Mi, Thomas R. Austin, Mary L. Biggs, David S. Siscovick , et al. · 2023

High-throughput proteomics allow researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic response…

Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis Open

Héléne T. Cronjé, Michael Mi, Thomas R. Austin, Mary L. Biggs, David S. Siscovick , et al. · 2023

High-throughput proteomics allow researchers to simultaneously explore the roles of thousands of biomarkers in the pathophysiology of diabetes. We conducted proteomic association studies of incident type 2 diabetes and physiologic response…

Proteomics in oral cancer Open

Shrikanth Muralidharan, Prashant Rao, Prasad Karande, Shashank Gaikwad, Amod Patankar · 2022

Background: This review aims to develop comprehensive evidence regarding proteomics in oral cancer initiation, regulation, and progress/inhibition. Material and Methods: A systematic review was carried out of all the reported literature on…

Genomics in oral cancer Open

Shrikanth Muralidharan, Swapna Patankar, Y. SHAH, Prashant Rao, Prasad Karande · 2022

Background: The genetic factors play an essential role in the cell behavior and function in areas affected with cancer, identifying them could help faster risk detection and mitigation of cases that can be easily saved without much therape…

Purification and biochemical analysis of native AMPA receptors from three different mammalian species Open

Prashant Rao, Eric Gouaux · 2022

The majority of fast, excitatory synaptic transmission in the central nervous system (CNS) is mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), which are glutamate-activated ion channels integral to synap…

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition Open

Jie Yu, Prashant Rao, Sarah Clark, Jaba Mitra, Taekjip Ha , et al. · 2021

Data for EMSL Project 51007 from March 2021 Open

Eric Gouaux, Janette Myers, Jie Yu, Prashant Rao, Heidi Owen · 2021

Data for EMSL Project 51007 from March 2020 Open

Eric Gouaux, Janette Myers, Jie Yu, Prashant Rao, Heidi Owen · 2020

Data for EMSL Project 50633 from February 2020 Open