Prashant S. Kharkar
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View article: A brief review on metal-curcumin complexes: synthesis approaches and their pharmaceutical applications
A brief review on metal-curcumin complexes: synthesis approaches and their pharmaceutical applications Open
Curcumin is a key polyphenolic component of turmeric. In recent years, curcumin has gained considerable attention because of its diverse biological potential, such as its anti-inflammatory, antioxidant, and anticancer effects. A growing fi…
View article: N- and O-Trideuteromethylation of Drugs and Intermediates with Trimethyloxosulphonium Iodide-d 9 Enabled by a Mechanochemical Synthesis
N- and O-Trideuteromethylation of Drugs and Intermediates with Trimethyloxosulphonium Iodide-d 9 Enabled by a Mechanochemical Synthesis Open
Solvent-free, sustainable organic synthetic approaches based on the use of microwaves, ultrasound, or mechanochemistry are needed from a green chemistry perspective. Mechanochemical synthesis involves the coupling of mechanical and chemica…
View article: Peptide Mold: A Novel Strategy for Mapping Potential Binding Sites in Protein Targets
Peptide Mold: A Novel Strategy for Mapping Potential Binding Sites in Protein Targets Open
A novel concept titled ‘Peptide Mold’ for mapping potential binding sites in protein targets is presented. A large multiconformer tetrapeptide library comprising of 32 million conformations of all possible combinations of naturally-occurri…
View article: NEURAL NETWORK-BASED ADVERSE DRUG REACTION PREDICTION USING MOLECULAR SUBSTRUCTURE ANALYSES
NEURAL NETWORK-BASED ADVERSE DRUG REACTION PREDICTION USING MOLECULAR SUBSTRUCTURE ANALYSES Open
Objective: This study aims to enhance early detection and prediction by exploiting drug molecular substructures, overcoming challenges posed by limited authentic patient data in the medical domain. Methods: The study implemented a neural n…
View article: Peptide Mold: A Novel Strategy for Mapping Potential Binding Sites in Protein Targets
Peptide Mold: A Novel Strategy for Mapping Potential Binding Sites in Protein Targets Open
A novel concept titled ‘Peptide Mold’ for mapping potential binding sites in protein targets is presented. A large multiconformer tetrapeptide library comprising of 32 million conformations of all possible combinations of naturally-occurri…
View article: Retraction Note: Extremely active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes
Retraction Note: Extremely active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes Open
View article: Neural Network Based Adverse Drug Reactions Prediction Using Molecular Substructure Analyses
Neural Network Based Adverse Drug Reactions Prediction Using Molecular Substructure Analyses Open
View article: Banana Peel Waste: An Emerging Cellulosic Material to Extract Nanocrystalline Cellulose
Banana Peel Waste: An Emerging Cellulosic Material to Extract Nanocrystalline Cellulose Open
Nanocrystalline cellulose (NCC) has gained attention due to its versatile properties such as biocompatibility, sustainability, high aspect ratio, and abundance of -OH groups that favor modifications of NCC. The objective of this paper is t…
View article: Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review
Human Milk Oligosaccharides as Potential Antibiofilm Agents: A Review Open
Surface-associated bacterial communities called biofilms are ubiquitous in nature. Biofilms are detrimental in medical settings due to their high tolerance to antibiotics and may alter the final pathophysiological outcome of many healthcar…
View article: RETRACTED ARTICLE: Extremely Active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes
RETRACTED ARTICLE: Extremely Active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes Open
Background Fertility preservation and restoration in cancer patients/survivors is the need of present times when increased numbers of patients get cured of cancer but face infertility as a serious side effect. Resveratrol has beneficial ef…
View article: Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery
Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery Open
A major global health risk has been witnessed with the development of drug-resistant bacteria and multidrug-resistant pathogens linked to significant mortality. Coumarins are heterocyclic compounds belonging to the benzophenone class enric…
View article: Crocetin and related oxygen <scp>diffusion‐enhancing</scp> compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications
Crocetin and related oxygen <span>diffusion‐enhancing</span> compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications Open
The current pandemic forced us to introspect and revisit our armamentarium of medicinal agents which could be life‐saving in emergency situations. Oxygen diffusion‐enhancing compounds represent one such class of potential therapeutic agent…
View article: Synthesis, molecular docking,and biological evaluationof novel 2-(3-chlorophenyl)quinoline-4-carboxamide derivatives as potent anti-breast cancer and antibacterial agents
Synthesis, molecular docking,and biological evaluationof novel 2-(3-chlorophenyl)quinoline-4-carboxamide derivatives as potent anti-breast cancer and antibacterial agents Open
Objectives: The study aims to synthesize and to evaluate the anti-breast cancer and antibacterial activity of some novel quinoline-4-carboxamide derivatives. Materials and Methods: A series of novel quinoline analogs 6a-6j with varied subs…
View article: Drug repurposing for Breast Cancer: Preliminary medicinal chemistry investigations and future perspectives
Drug repurposing for Breast Cancer: Preliminary medicinal chemistry investigations and future perspectives Open
<p>Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology,<br>\nMatunga (East), Mumbai-400 019, India<br>\nShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM&rsqu…
View article: Synthesis, Docking Studies and Biological Evaluation of Novel N-(2-(3-fluorophenyl)-quinolin-5-yl)benzamide Derivatives as Potent Anti-breast Cancer Agents
Synthesis, Docking Studies and Biological Evaluation of Novel N-(2-(3-fluorophenyl)-quinolin-5-yl)benzamide Derivatives as Potent Anti-breast Cancer Agents Open
A novel series of quinoline benzamide derivatives have been synthesized and screened for their anticancer activity against a breast cancer cell line (MDA-MB-231) by MTT assay method. All the synthesized compounds were confirmed by spectral…
View article: Novel analogs of sulfasalazine as system x<sub>c</sub><sup>−</sup> antiporter inhibitors: Insights from the molecular modeling studies
Novel analogs of sulfasalazine as system x<sub>c</sub><sup>−</sup> antiporter inhibitors: Insights from the molecular modeling studies Open
System x c − (Sx c − ), a cystine‐glutamate antiporter, is established as an interesting target for the treatment of several pathologies including epileptic seizures, glioma, neurodegenerative diseases, and multiple sclerosis. Erastin, sor…
View article: Correction: Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in <i>Pseudomonas aeruginosa via</i> LasIR/RhlIR circuitry
Correction: Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in <i>Pseudomonas aeruginosa via</i> LasIR/RhlIR circuitry Open
Correction for ‘Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in Pseudomonas aeruginosa via LasIR/RhlIR circuitry’ by Mayank D. Shah et al., RSC Adv., 2019, 9, 40228–40239.
View article: Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in<i>Pseudomonas aeruginosa via</i>LasIR/RhlIR circuitry
Potassium 2-methoxy-4-vinylphenolate: a novel hit exhibiting quorum-sensing inhibition in<i>Pseudomonas aeruginosa via</i>LasIR/RhlIR circuitry Open
Effect of potassium 2-methoxy-4-vinylphenolate on quorum sensing inPseudomonas aeruginosa.
View article: Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2
Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2 Open
View article: Discovery of novel human inosine 5′-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents
Discovery of novel human inosine 5′-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents Open
View article: Newer human inosine 5′-monophosphate dehydrogenase 2 (<i>h</i>IMPDH2) inhibitors as potential anticancer agents
Newer human inosine 5′-monophosphate dehydrogenase 2 (<i>h</i>IMPDH2) inhibitors as potential anticancer agents Open
Human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2), being an age-old target, has attracted attention recently for anticancer drug development. Mycophenolic acid (MPA), a well-known immunosuppressant drug, was used a lead structure to…
View article: Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors
Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors Open
View article: Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents
Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents Open
View article: Attenuation of quorum sensing-regulated behaviour by Tinospora cordifolia extract & identification of its active constituents
Attenuation of quorum sensing-regulated behaviour by Tinospora cordifolia extract & identification of its active constituents Open
Background & objectives: The pathogenicity of the nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii is regulated by their quorum sensing (QS) systems. The objective of the present study was to examine the effect of t…
View article: Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties
Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties Open
A series of new Schiff’s bases was obtained from the sulfanilamide semicarbazone (4-aminosulfonylphenyl semicarbazide) and aromatic/heterocyclic aldehydes. The new compounds were designed to incorporate moieties known to induce effective i…
View article: Ligand-Based Virtual Screening using Random Walk Kernel and Empirical Filters
Ligand-Based Virtual Screening using Random Walk Kernel and Empirical Filters Open
Drug discovery is a time-consuming and costly process. The data generated during various stages of the drug discovery is drastically increasing and it forces machine-learning scientist to implement more effective and fast methods for the u…