Prashanth Asuri
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Competitive Value of Acquiring Novel FDA Product Codes for Medical Device Manufacturers An Original Investigation Open
The FDA classifies medical devices by risk, assigning each a Product Code (PC) that determines its regulatory pathway for clearance. Novel PCs are created when new technologies raise safety or efficacy questions not addressed by existing c…
Stem cell-based approaches for developmental neurotoxicity testing Open
Neurotoxicants are substances that can lead to adverse structural or functional effects on the nervous system. These can be chemical, biological, or physical agents that can cross the blood brain barrier to damage neurons or interfere with…
Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels Open
Controlled delivery of proteins has immense potential for the treatment of various human diseases, but effective strategies for their delivery are required before this potential can be fully realized. Recent research has identified hydroge…
Sandwich Culture Platforms to Investigate the Roles of Stiffness Gradients and Cell–Matrix Adhesions in Cancer Cell Migration Open
Given the key role of cell migration in cancer metastasis, there is a critical need for in vitro models that better capture the complexities of in vivo cancer cell microenvironments. Using both two-dimensional (2D) and three-dimensional (3…
Silver nanoparticle interactions with glycated and non-glycated human serum albumin mediate toxicity Open
Introduction: Biomolecules bind to and transform nanoparticles, mediating their fate in biological systems. Despite over a decade of research into the protein corona, the role of protein modifications in mediating their interaction with na…
Editorial: Protein-Material interfaces: Fundamentals and applications volume II Open
EDITORIAL article Front. Mol. Biosci., 17 January 2023Sec. Biophysics Volume 10 - 2023 | https://doi.org/10.3389/fmolb.2023.1137613
Silver Nanoparticle Surface Chemistry Determines Interactions with Human Serum Albumin and Cytotoxic Responses in Human Liver Cells Open
Engineered nanomaterials (ENMs) are synthesized with a diversity of surface chemistries that mediate biochemical interactions and physiological response to the particles. In this work, silver engineered nanomaterials (AgENMs) are used to e…
Modeling the Additive Effects of Nanoparticles and Polymers on Hydrogel Mechanical Properties Using Multifactor Analysis Open
Interpenetrating networks (IPN)s have been conceived as a biomimetic tool to tune hydrogel mechanical properties to the desired target formulations. In this study, the rheological behavior of acrylamide (AAm) [2.5–10%] hydrogels crosslinke…
Role of Polymer Concentration and Crosslinking Density on Release Rates of Small Molecule Drugs Open
Over the past few years, researchers have demonstrated the use of hydrogels to design drug delivery platforms that offer a variety of benefits, including but not limited to longer circulation times, reduced drug degradation, and improved t…
Editorial: Protein-Material Interfaces: Fundamentals and Applications Open
EDITORIAL article Front. Mol. Biosci., 18 March 2022Sec. Biophysics https://doi.org/10.3389/fmolb.2022.864005
Multifunctional Hydrogel Nanocomposites for Biomedical Applications Open
Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shor…
Multifunctional Hydrogel Nanocomposites for Biomedical Applications Open
Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shor…
Combined Effects of Confinement and Macromolecular Crowding on Protein Stability Open
Confinement and crowding have been shown to affect protein fates, including folding, functional stability, and their interactions with self and other proteins. Using both theoretical and experimental studies, researchers have established t…
Low‐Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells Open
Silver nanoparticles (AgNPs) are widely incorporated into consumer and biomedical products for their antimicrobial and plasmonic properties with limited risk assessment of low‐dose cumulative exposure in humans. To evaluate cellular respon…
Role of Nanoparticle–Polymer Interactions on the Development of Double-Network Hydrogel Nanocomposites with High Mechanical Strength Open
Extensive experimental and theoretical research over the past several decades has pursued strategies to develop hydrogels with high mechanical strength. Our study investigated the effect of combining two approaches, addition of nanoparticl…
Role of Nanoparticle-Polymer Interactions on the Development of Double-Network Hydrogel Nanocomposites with High Mechanical Strength Open
Extensive experimental and theoretical research over the past several decades has culminated in the understanding of the mechanisms behind nanoparticle-mediated enhancements on the mechanical properties of hydrogels. This information is no…
Exploring the Role of Nanoparticles in Enhancing Mechanical Properties of Hydrogel Nanocomposites Open
Over the past few decades, research studies have established that the mechanical properties of hydrogels can be largely impacted by the addition of nanoparticles. However, the exact mechanisms behind such enhancements are not yet fully und…
Exploring the Effects of Nanoparticle Incorporation on the Mechanical Properties of Hydrogels Open
Recent studies have expanded our understanding of the effects of nanoparticles on hydrogel mechanical properties. However, further studies are needed to validate the generality of these findings, as well as to determine the exact mechanism…
Effect of crosslinker length on the elastic and compression modulus of poly(acrylamide) nanocomposite hydrogels Open
Polymer hydrogelshave shown to exhibit improved properties upon the addition of nanoparticles; however, the mechanical underpinnings behind these enhancements have not been fully elucidated. Moreover, fewer studies have focused on developi…
Droplet Microfluidic Platform for the Determination of Single-Cell Lactate Release Open
Cancer cells release high levels of lactate that has been correlated to increased metastasis and tumor recurrence. Single-cell measurements of lactate release can identify malignant cells and help decipher metabolic cancer pathways. We pre…