Prashanth Vas
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A New, Simple, Pragmatic Clinical Staging of Distal Symmetrical Polyneuropathy in Diabetes: Will it Improve Organisation of Diabetic Foot Care? Open
Length-dependent distal symmetrical polyneuropathy (DSPN) represents a highly prevalent complication associated with diabetes. Current standards for clinical diagnosis, severity assessment, and comprehensive staging of DSPN remain ambiguou…
Peripheral Arterial Disease in Diabetic Foot: One Disease with Multiple Patterns Open
Peripheral arterial disease (PAD) is a major complication in individuals with diabetes and is increasingly prevalent in those with diabetic foot ulcers (DFUs). Despite this, the characterisation of PAD in diabetic patients remains insuffic…
Ten years trajectories of estimated glomerular filtration rate (eGFR) in a multiethnic cohort of people with type 1 diabetes and preserved renal function Open
Objectives We aim to evaluate estimated glomerular filtration rate (eGFR) patterns of progression in a multiethnic cohort of people with type I diabetes mellitus and with baseline eGFR ≥45 mL/min/1.73 m 2 . Design Observational cohort. Set…
HbA1c variability is independently associated with progression of diabetic kidney disease in an urban multi-ethnic cohort of people with type 1 diabetes Open
Aims/hypothesis The role of HbA 1c variability in the progression of diabetic kidney disease is unclear, with most studies to date performed in White populations and limited data on its role in predicting advanced kidney outcomes. Our aim …
Improving Physical, Physiological, and Psychological Health Outcomes in Patients with Diabetic Foot Ulcers – State of the Art Open
Diabetic foot disease is a complex and challenging complication of diabetes mellitus, which imposes a significant burden of disease on patients, their carers, and the wider health systems. Recurrence rates are high, and current evidence in…
View article: Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit
Standards of diabetes care and burden of hypoglycaemia in people with diabetes on peritoneal dialysis: Results from a real-world clinical audit Open
There is limited data on the standards of diabetes care in people on peritoneal dialysis (PD). Our aim was to assess the standards of diabetes care and the burden of hypoglycaemia in people with diabetes on PD. We performed a retrospective…
Evaluation of Adjuvant Antibiotic Loaded Injectable Bio-Composite Material in Diabetic Foot Osteomyelitis and Charcot Foot Reconstruction Open
The management of diabetic foot osteomyelitis (DFO) is extremely challenging with high amputation rates reported alongside a five-year mortality risk of more than fifty percent. We describe our experience in using adjuvant antibiotic-loade…
People with type 1 diabetes of African-Caribbean ethnicity are at increased risk of developing sight-threatening diabetic retinopathy Open
Objective There is limited information on the effect of ethnicity on the development of referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. To describe the risk-factors for STDR in a diverse cohort of …
People With Type 1 Diabetes of African Caribbean Ethnicity Are at Increased Risk of Developing Sight-Threatening Diabetic Retinopathy Open
OBJECTIVE There is limited information on the effect of ethnicity on the development of referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. This study describes the risk factors for STDR in a diverse coh…
People with type 1 diabetes of African-Caribbean ethnicity are at increased risk of developing sight-threatening diabetic retinopathy Open
Objective There is limited information on the effect of ethnicity on the development of referable sight-threatening diabetic retinopathy (STDR) in people with type 1 diabetes. To describe the risk-factors for STDR in a diverse cohort of …
View article: Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT
Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT Open
Background The mainstay of treatment for diabetic peripheral neuropathic pain is pharmacotherapy, but the current National Institute for Health and Care Excellence guideline is not based on robust evidence, as the treatments and their comb…
African-Caribbean ethnicity is an independent predictor of significant decline in kidney function in people with type 1 diabetes Open
Objective: The aim of the study was to identify the demographic and clinical features in an urban cohort of people with type 1 diabetes who developed ≥50% decline in estimated glomerular filtration rate (eGFR). Research design and metho…
African-Caribbean ethnicity is an independent predictor of significant decline in kidney function in people with type 1 diabetes Open
Objective: The aim of the study was to identify the demographic and clinical features in an urban cohort of people with type 1 diabetes who developed ≥50% decline in estimated glomerular filtration rate (eGFR). Research design and metho…
View article: Multimodal testing reveals subclinical neurovascular dysfunction in prediabetes, challenging the diagnostic threshold of diabetes
Multimodal testing reveals subclinical neurovascular dysfunction in prediabetes, challenging the diagnostic threshold of diabetes Open
Aim To explore if novel non‐invasive diagnostic technologies identify early small nerve fibre and retinal neurovascular pathology in prediabetes. Methods Participants with normoglycaemia, prediabetes or type 2 diabetes underwent an explora…
African Caribbean Ethnicity Is an Independent Predictor of Significant Decline in Kidney Function in People With Type 1 Diabetes Open
OBJECTIVE The aim of the study was to identify the demographic and clinical features in an urban cohort of people with type 1 diabetes who developed a ≥50% decline in estimated glomerular filtration rate (eGFR). RESEARCH DESIGN AND METHODS…
Topical oxygen therapy for healing diabetic foot ulcers: A systematic review and meta-analysis of randomised control trials Open
Background: Topical oxygen therapy (TOT) has been suggested to improve the likelihood of complete wound healing. Methods: A systematic review of PUBMED, Embase and clinicaltrials.gov databases from inception until December 2021 for eligibl…
Editorial: Understanding Diabetic Foot Disease: Current Status and Emerging Treatment Approaches Open
EDITORIAL article Front. Endocrinol., 16 September 2021 | https://doi.org/10.3389/fendo.2021.753181
Diabetic Peripheral Neuropathy and Depression: Dancing with Wolves? - Mini-Review and Commentary on Alghafri <i>et al</i> . "Screening for depressive symptoms amongst patients with diabetic peripheral neuropathy" Open
The co-existence of diabetic peripheral neuropathy (DPN) and depression in subjects with diabetes is being increasingly recognized. The interaction of these two serious comorbidities may increase morbidity and mortality. An emerging though…
Could Exogenous Insulin Ameliorate the Metabolic Dysfunction Induced by Glucocorticoids and COVID-19? Open
The finding that high-dose dexamethasone improves survival in those requiring critical care due to COVID-19 will mean much greater usage of glucocorticoids in the subsequent waves of coronavirus infection. Furthermore, the consistent findi…
COVID-19 Toes and Other Skin Lesions During the Pandemic: Emerging Entities? Open
There is accumulating evidence to indicate an association between coronavirus infectious disease 2019 (COVID-19) and clusters of incident cutaneous eruptions. Of these, chilblains-like perniosis have received widespread medical and media a…
View article: Small Fiber Neuropathy in Diabetes Polyneuropathy: Is It Time to Change?
Small Fiber Neuropathy in Diabetes Polyneuropathy: Is It Time to Change? Open
Diabetes polyneuropathy is an important complication of diabetes polyneuropathy, and its notable sequelae of foot ulceration, autonomic dysfunction, and neuropathic pain are associated with significant morbidity and mortality. Despite the …
View article: The Role of Bone Scintigraphy with SPECT/CT in the Characterization and Early Diagnosis of Stage 0 Charcot Neuroarthropathy
The Role of Bone Scintigraphy with SPECT/CT in the Characterization and Early Diagnosis of Stage 0 Charcot Neuroarthropathy Open
We describe the use of Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) in the investigation and diagnosis of Charcot neuroarthropathy (CN) in patients with a hot swollen foot but normal radiographs and clinical su…
Recent advances in treatment of haemodialysis Open
Haemodialysis remains the most widely used treatment for patients with end-stage renal disease. Despite the progress that has occurred in the treatment of end-stage renal disease over the last six decades, there has been a failure to trans…