Pratap Meera
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View article: Electrical synapses mediate visual approach behavior
Electrical synapses mediate visual approach behavior Open
Detecting salient visual objects and orienting toward them are commonplace tasks for animals, yet the underlying neural circuit mechanisms remain poorly understood. The fruit fly is an ideal model for a comprehensive analysis of feature de…
View article: Heterogeneity in the projections and excitability of tyraminergic/octopaminergic neurons that innervate the Drosophila reproductive tract
Heterogeneity in the projections and excitability of tyraminergic/octopaminergic neurons that innervate the Drosophila reproductive tract Open
Aminergic nuclei in mammals are generally composed of relatively small numbers of cells with broad projection patterns. Despite the gross similarity of many individual neurons, recent transcriptomic, anatomic and behavioral studies suggest…
View article: GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions
GABAA receptors as plausible molecular targets and mediators for taurine and homotaurine actions Open
Dementia and autoimmune diseases are prevalent conditions with limited treatment options. Taurine and homotaurine (HT) are naturally occurring sulfonate amino acids, with taurine being highly abundant in animal tissues, but declining with …
View article: The environmental toxicant ziram enhances neurotransmitter release and increases neuronal excitability via the EAG family of potassium channels
The environmental toxicant ziram enhances neurotransmitter release and increases neuronal excitability via the EAG family of potassium channels Open
Environmental toxicants have the potential to contribute to the pathophysiology of multiple complex diseases, but the underlying mechanisms remain obscure. One such toxicant is the widely used fungicide ziram, a dithiocarbamate known to ha…
View article: Receptor protein tyrosine phosphatases control Purkinje neuron firing
Receptor protein tyrosine phosphatases control Purkinje neuron firing Open
Spinocerebellar ataxias (SCA) are a genetically heterogeneous family of cerebellar neurodegenerative diseases characterized by abnormal firing of Purkinje neurons and degeneration. We recently demonstrated the slowed firing rates seen in s…
View article: Extrasynaptic δ‐<scp>GABA<sub>A</sub></scp> receptors are high‐affinity muscimol receptors
Extrasynaptic δ‐<span>GABA<sub>A</sub></span> receptors are high‐affinity muscimol receptors Open
Muscimol, the major psychoactive ingredient in the mushroom Amanita muscaria , has been regarded as a universal non‐selective GABA ‐site agonist. Deletion of the GABA A receptor ( GABA A R ) δ subunit in mice (δ KO ) leads to a drastic red…
View article: MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias
MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias Open
Significance The Src family of nonreceptor tyrosine kinases (SFK) is essential for nervous system function and may contribute to neurodegeneration. Spinocerebellar ataxias (SCAs) are neurodegenerative diseases in which Purkinje neurons fir…
View article: A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2
A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2 Open
Metabotropic glutamate receptor 1 (mGluR1) function in Purkinje neurons (PNs) is essential for cerebellar development and for motor learning and altered mGluR1 signaling causes ataxia. Downstream of mGluR1, dysregulation of calcium homeost…
View article: Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2
Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2 Open
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the ATXN2 gene. The repeat resides in an encoded region of the gene resulting in polyglutamine (polyQ) expansion whic…
View article: Cellular and circuit mechanisms underlying spinocerebellar ataxias
Cellular and circuit mechanisms underlying spinocerebellar ataxias Open
Degenerative ataxias are a common form of neurodegenerative disease that affect about 20 individuals per 100,000. The autosomal dominant spinocerebellar ataxias (SCAs) are caused by a variety of protein coding mutations (single nucleotide …