Prateek Raj
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View article: Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors
Targeting isoprenoid-precursor biosynthesis in Klebsiella pneumoniae: Design, synthesis and evaluation of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) inhibitors Open
Klebsiella pneumoniae is a critical-priority pathogen based on the 2024 WHO list and poses a significant threat to human health. The methylerythritol phosphate (MEP) pathway, crucial for isoprenoid biosynthesis in many pathogenic bacteria,…
View article: Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex
Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex Open
Capsular polysaccharides (CPS), which form the protective outer capsule surrounding many Gram-negative bacterial pathogens, are critical virulence determinants. Their biosynthesis is primarily carried out via the conserved Wzx/Wzy-dependen…
View article: Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex
Molecular insights into the capsular polysaccharide transporter Wza-Wzc complex Open
Capsular polysaccharides (CPS), which form the protective outer capsule surrounding many Gram-negative bacterial pathogens, are critical virulence determinants. Their biosynthesis is primarily carried out via the conserved Wzx/Wzy-dependen…
View article: Capsule-augmented scleral fixation of intraocular lenses
Capsule-augmented scleral fixation of intraocular lenses Open
In-the-bag placement of intraocular lenses (IOLs) generally yields optimal results in terms of alignment and minimizes decentration or tilt. However, this approach can be counterproductive if the capsular bag is compromised, potentially le…
View article: Exploring Choroidal Masses: A Comprehensive Guide
Exploring Choroidal Masses: A Comprehensive Guide Open
Choroidal osteoma is a rare benign ossifying tumor that is generally a unilateral condition in the juxtapapillary and macular area. There are multiple choroidal conditions that could remain asymptomatic and identified as an incidental find…
View article: Insights into cargo sorting by SNX32 and its role in neurite outgrowth
Insights into cargo sorting by SNX32 and its role in neurite outgrowth Open
Sorting nexins (SNX) are a family of proteins containing the Phox homology domain, which shows a preferential endo-membrane association and regulates cargo sorting processes. Here, we established that SNX32, an SNX-BAR (Bin/Amphiphysin/Rvs…
View article: Insights into cargo sorting by SNX32 in neuronal and non-neuronal cells: physiological implications in neurite outgrowth
Insights into cargo sorting by SNX32 in neuronal and non-neuronal cells: physiological implications in neurite outgrowth Open
Sorting nexins (SNX) are a family of proteins containing the Phox homology domain, which shows a preferential endo-membrane association and regulates cargo sorting processes. Even with the vast amount of information unveiled systematically…
View article: Identification of a new and diverse set of Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) inhibitors using structure-based virtual screening: Experimental validation and molecular dynamics studies
Identification of a new and diverse set of Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) inhibitors using structure-based virtual screening: Experimental validation and molecular dynamics studies Open
Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng), a key DNA repair enzyme, represents an attractive target for the design of new antimycobacterial agents. However, only a limited number of weak MtUng inhibitors are reported, prima…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1
Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1 Open
Mycobacterium smegmatis MutT1 (MsMutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-ox…
View article: Plasticity, ligand conformation and enzyme action of <i>Mycobacterium smegmatis</i> MutT1
Plasticity, ligand conformation and enzyme action of <i>Mycobacterium smegmatis</i> MutT1 Open
Mycobacterium smegmatis MutT1 ( Ms MutT1) is a sanitation enzyme made up of an N-terminal Nudix hydrolase domain and a C-terminal domain resembling a histidine phosphatase. It has been established that the action of MutT1 on 8-oxo-dGTP, 8-…
View article: Essential and selective role of SNX12 in transport of endocytic and retrograde cargo
Essential and selective role of SNX12 in transport of endocytic and retrograde cargo Open
The endosomal protein-sorting machineries play vital roles in diverse physiologically important cellular processes. Much of the core membrane-sorting apparatus is conserved in evolution, such as retromer, which is involved in the recycling…