Prathamesh Chati
YOU?
Author Swipe
View article: Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis Open
Blood transfusion plays a vital role in modern medicine, but frequent shortages occur. Ex vivo manufacturing of red blood cells (RBCs) from universal donor cells offers a potential solution, yet the high cost of recombinant cytokines remai…
View article: Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis
Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis Open
Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from uni…
View article: Uncovering differential tolerance to deletions versus substitutions with a protein language model
Uncovering differential tolerance to deletions versus substitutions with a protein language model Open
Deep mutational scanning (DMS) experiments have been successfully leveraged to understand genotype to phenotype mapping, with broad implications for protein engineering, human genetics, drug development, and beyond. To date, however, the o…
View article: Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis Open
Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from uni…
View article: Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis Open
Blood transfusion plays a vital role in modern medicine. However, availability is contingent on donated blood, and frequent shortages pose a significant healthcare challenge. Ex vivo manufacturing of red blood cells (RBCs) derived from uni…
View article: High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival
High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival Open
View article: High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival
High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival Open
Numerous cell states are known to comprise the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, the developmental stemness and co-occurrence of these cell states remain poorly defined. Here, we performed singl…
View article: High-dimensional deconstruction of pancreatic ductal adenocarcinoma identifies tumor microenvironmental communities associated with survival
High-dimensional deconstruction of pancreatic ductal adenocarcinoma identifies tumor microenvironmental communities associated with survival Open
Bulk and single-cell analyses of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) have revealed a largely immunosuppressive milieu. Thus far, efforts to utilize insights from TME features to facilitate more effectiv…
View article: Derivation of Distinct Prognostic Tumor Cell States in PDAC via Single-Cell RNA Sequencing
Derivation of Distinct Prognostic Tumor Cell States in PDAC via Single-Cell RNA Sequencing Open
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer type with a poor prognosis. There is a critical need for robust biomarkers to better risk-stratify patients and personalize treatment. Here, we utilize single-cell RNA sequenc…