Prathima Anandi
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View article: Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity
Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity Open
TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity. We hypothesized that among TPMT and …
View article: <i>TPMT</i> and <i>NUDT15</i> Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real‐World Clinical Results
<i>TPMT</i> and <i>NUDT15</i> Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real‐World Clinical Results Open
Azathioprine is used frequently to treat several inflammatory conditions. However, treatment is limited by adverse events—in particular, myelotoxicity. Thiopurine‐S‐methyltransferase (TPMT) and nudix hydrolase‐15 (NUDT15) are enzymes invol…
View article: Framingham Risk Score Is an Ineffective Screening Strategy for Coronary Heart Disease in Long-Term Allogeneic Hematopoietic Cell Transplant Survivors
Framingham Risk Score Is an Ineffective Screening Strategy for Coronary Heart Disease in Long-Term Allogeneic Hematopoietic Cell Transplant Survivors Open
Long-term allogeneic hematopoietic cell transplant (allo-HCT) survivors suffer an elevated risk of coronary heart disease (CHD). We conducted a prospective, nonrandomized, cross-sectional study to screen asymptomatic survivors at a single …
View article: Increased Incidence of Resistant Hypertension in Patients With Systemic Lupus Erythematosus: A Retrospective Cohort Study
Increased Incidence of Resistant Hypertension in Patients With Systemic Lupus Erythematosus: A Retrospective Cohort Study Open
Objective To compare the risk of resistant hypertension ( RHTN ) in patients with systemic lupus erythematosus ( SLE ) and in controls without SLE , and to define factors associated with RHTN in patients with SLE . Methods We studied 1,044…
View article: Distinct Biomarker Profiles in Ex Vivo T Cell Depletion Graft Manipulation Strategies: CD34+ Selection versus CD3+/19+ Depletion in Matched Sibling Allogeneic Peripheral Blood Stem Cell Transplantation
Distinct Biomarker Profiles in Ex Vivo T Cell Depletion Graft Manipulation Strategies: CD34+ Selection versus CD3+/19+ Depletion in Matched Sibling Allogeneic Peripheral Blood Stem Cell Transplantation Open
Various approaches have been developed for ex vivo T cell depletion in allogeneic stem cell transplantation to prevent graft-versus-host disease (GVHD). Direct comparisons of T cell depletion strategies have not been well studied, however.…
View article: Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells is a Safe Strategy to Prevent Viral Reactivation in Recipients of Allogeneic T Cell Depleted Stem Cell Transplant
Early Adoptive Transfer of Ex Vivo Generated Multi-Virus Specific T Cells is a Safe Strategy to Prevent Viral Reactivation in Recipients of Allogeneic T Cell Depleted Stem Cell Transplant Open
Background: Reactivation of latent viruses in allogeneic stem cell transplant (SCT) recipients significantly increases the risk for non-relapse mortality. Ex vivo generated virus specific T cells can effectively treat infections post-SCT b…
View article: Risk Factors for Human Papilloma Virus Reactivation in the Genital Tract of Female Stem Cell Transplant Survivors
Risk Factors for Human Papilloma Virus Reactivation in the Genital Tract of Female Stem Cell Transplant Survivors Open
Human Papillomavirus (HPV) infection inducing cervical, vaginal, and vulvar warts and leading to cervical cancer is a significant risk for women after stem cell transplantation (SCT). Determining risk factors and the course of HPV disease …
View article: Improved Reproducibility of Gvhd Biomarker Assay- Application of Multiplex Microfluidic Channel System
Improved Reproducibility of Gvhd Biomarker Assay- Application of Multiplex Microfluidic Channel System Open
A major limitation to graft versus host disease (GVHD) research is that diagnosis relies on clinical symptoms and biopsy of the involved organs. Proteomic studies identified serum or plasma protein markers to predict the non-relapse mortal…
View article: ST2 is Associated with GVHD in Ex Vivo Graft Manipulation Strategies for Allogeneic Peripheral Blood Stem Cell Transplantation
ST2 is Associated with GVHD in Ex Vivo Graft Manipulation Strategies for Allogeneic Peripheral Blood Stem Cell Transplantation Open
Graft-versus-host disease (GVHD) is the leading cause of non-relapse mortality after allogeneic stem cell transplantation (allo-SCT). Recent progress in GVHD research identified three promising proteomic biomarkers (ST2, Reg3α, and sTNFR1)…
View article: Conservative management of neurocysticercosis in a patient with hematopoietic stem cell transplantation: a case report and review
Conservative management of neurocysticercosis in a patient with hematopoietic stem cell transplantation: a case report and review Open
Neurocysticercosis, an infection of the central nervous system with the larval stage of the cestode T aenia solium , is common in developing countries but its occurrence and management in allogeneic hematopoietic stem cell transplantation …
View article: Minor ABO Incompatibility Does Not Impact Nonrelapse Mortality in T Cell–Depleted Human Leukocyte Antigen–Matched Sibling Transplantation
Minor ABO Incompatibility Does Not Impact Nonrelapse Mortality in T Cell–Depleted Human Leukocyte Antigen–Matched Sibling Transplantation Open
ABO incompatibility (ABO-I) is known to produce hemolytic complications including acute hemolysis, passenger lymphocyte syndrome, delayed transfusion dependence, and pure red cell aplasia [1Booth G.S. Gehrie E.A. Bolan C.D. Savani B.N. Cli…
View article: Minor ABO Incompatibility Does Not Impact Non-Relapse Mortality in T-Cell Depleted HLA-Matched Sibling Transplantation
Minor ABO Incompatibility Does Not Impact Non-Relapse Mortality in T-Cell Depleted HLA-Matched Sibling Transplantation Open
ABO incompatibility (ABO-I) in allogeneic stem cell transplantation is known to produce hemolytic complications including acute hemolysis, the passenger lymphocyte syndrome, delayed transfusion dependence and pure red cell aplasia. Hemolys…
View article: Cardiac CT Imaging Is a Feasible Screening Strategy for Coronary Artery Disease (CAD) in Long Term Allogeneic Stem Cell Transplant (Allo-SCT) Survivors
Cardiac CT Imaging Is a Feasible Screening Strategy for Coronary Artery Disease (CAD) in Long Term Allogeneic Stem Cell Transplant (Allo-SCT) Survivors Open
Significant increases in CAD risk and cardiovascular events have been described in long-term allo-SCT survivors compared to age and gender-matched population controls. Since pharmacologic interventions, such as statins, positively influenc…
View article: Blood Stream Infection Is Frequent during Conditioning but Does Not Impact Allogeneic Transplant Outcomes in the Modern Era
Blood Stream Infection Is Frequent during Conditioning but Does Not Impact Allogeneic Transplant Outcomes in the Modern Era Open
Bacteremia occurs frequently in the neutropenic period of early allogeneic stem cell transplantation (SCT). Effective strategies have been developed for the rapid diagnosis and management of bacteremia in immunocompromised SCT recipients. …
View article: Bone Mineral Density (BMD) Improves in Survivors in Their Second Decade Post-Allogeneic Stem Cell Transplantation and Is Influenced By Body Mass Index (BMI) and Age
Bone Mineral Density (BMD) Improves in Survivors in Their Second Decade Post-Allogeneic Stem Cell Transplantation and Is Influenced By Body Mass Index (BMI) and Age Open
Rapid and profound BMD loss occur in the first year after allogeneic stem cell transplantation (SCT) and attributed to steroid exposure, chronic GVHD (cGVHD), conditioning, age and gender. However, changes in BMD in very long-term survivor…
View article: A Rare Consequence of Chronic Graft Versus Host Disease - Peyronie's Disease
A Rare Consequence of Chronic Graft Versus Host Disease - Peyronie's Disease Open
Chronic graft versus host disease (GvHD) after allogeneic stem cell transplantation (SCT) may involve any organ system, but male genital involvement is rare. Peyronie's Disease (PD) is an acquired, localized fibrotic disorder of the tunica…