Pratik Vikhe
YOU?
Author Swipe
View article: DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome Open
Down syndrome (DS), which arises from trisomy of the whole or part of chromosome 21 (Hsa21), is one of the most common genetic abnormalities in humans. DS manifests as a broad spectrum of phenotypic features, including hearing loss due to …
View article: DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome Open
Down syndrome (DS), which arises from trisomy of the whole or part of chromosome 21 (Hsa21), is one of the most common genetic abnormalities in humans. DS manifests as a broad spectrum of phenotypic features, including hearing loss due to …
View article: Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype
Ikaros Degradation By CC-220 (Iberdomide) Correlates with Normalization of SLE CD4 T Cell Phenotype Open
Introduction: CC-220 is a second-generation IMiD drug that degrades members of the IKZF family and is being explored for treating Systemic Lupus Erythematosus (SLE). SLE is driven by an abnormal immune response, and adaptive immune cells s…
View article: DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome Open
Down syndrome (DS), which arises from trisomy of the whole or part of chromosome 21 (Hsa21), is one of the most common genetic abnormalities in humans. DS manifests as a broad spectrum of phenotypic features, including hearing loss due to …
View article: Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques Open
The eradication of the viral reservoir represents the major obstacle to the development of a clinical cure for established HIV-1 infection. Here, we demonstrate that the administration of N-803 (brand name Anktiva) and broadly neutralizing…
View article: Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT
Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT Open
Aims Mitochondrial Complex I assembly (MCIA) is a multi-step process that necessitates the involvement of a variety of assembly factors and chaperones to ensure that the final active enzyme is correctly assembled. The role of the assembly …
View article: Insights into Otitis Media: Dissecting the interaction of C-Reactive Protein with Non-Typeable Haemophilus influenzae
Insights into Otitis Media: Dissecting the interaction of C-Reactive Protein with Non-Typeable Haemophilus influenzae Open
Otitis Media (OM) is the inflammation of the middle ear (ME). Non-typeable Haemophilus influenzae (NTHi) is one of the leading otopathogens in causing OM. Phosphocholine (PCho) on the NTHi lipopolysaccharide influences host-pathogen intera…
View article: Tissue specific requirements for ECSIT in mitochondrial complex I assembly
Tissue specific requirements for ECSIT in mitochondrial complex I assembly Open
Here we describe a mutation in the mitochondrial complex I assembly factor (Evolutionarily conserved signalling intermediate in Toll pathway) ECSIT which reveals tissue specific requirements for this factor in complex I assembly. Mitochond…
View article: The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects
The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects Open
Chronic otitis media (OM) is the most common cause of hearing loss worldwide, yet the underlying genetics and molecular pathology are poorly understood. The mouse mutant Jeff is a single gene mouse model for OM identified from a deafness s…
View article: Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media
Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media Open
The Jeff mouse mutant carries a mutation in the F-box only 11 gene (Fbxo11) and heterozygous animals display conductive deafness due to the development of otitis media (OM). The Fbxo11 locus is also associated with chronic otitis media wit…
View article: Cellular Immune Response against Nontypeable <i>Haemophilus influenzae</i> Infecting the Preinflamed Middle Ear of the <i>Junbo</i> Mouse
Cellular Immune Response against Nontypeable <i>Haemophilus influenzae</i> Infecting the Preinflamed Middle Ear of the <i>Junbo</i> Mouse Open
Nontypeable Haemophilus influenzae (NTHi) is a major pathogen causing acute otitis media (AOM). The pathology of AOM increases during long-term infection in the middle ear (ME), but the host cellular immune response to bacterial infection …
View article: Cellular content plays a crucial role in Non‐typeable<i>Haemophilus influenzae</i>infection of preinflamed<i>Junbo</i>mouse middle ear
Cellular content plays a crucial role in Non‐typeable<i>Haemophilus influenzae</i>infection of preinflamed<i>Junbo</i>mouse middle ear Open
Non-typeable Haemophilus influenzae (NTHi) is a major pathogen causing acute otitis media (AOM). The relationship between the cellular content of the middle ear fluid (MEF) during AOM and infection of NTHi is poorly understood. Using the J…