Explanipedia

3H-pyrazolo[4,3-f]quinoline hinge binder, a tunable scaffold for development of novel kinase inhibitors against FLT3-driven leukemia Open

Neetu Dayal, Eva Řezníčková, Delmis E. Hernandez, Miroslav Peřina, Jakub Bělíček , et al. · 2025

The 3H-pyrazolo[4,3-f]quinoline moiety, synthesized via a Doebner or Povarov multi-component reaction, has been described as an innovative scaffold capable of interacting with the hinge region of several protein kinases, including FLT3. Th…

Screening, characterization, and phylogenetic analysis of Methioninase-Producing Indigenous Streptomyces spp. Isolated from the Upper Lake of Bhopal, Madhya Pradesh, India Open

Pratik Yadav, Rakesh Mehta, Ragini Gothalwal · 2025

Methioninase, an enzyme with potential for cancer treatment, catalyzes the degradation of methionine, which supports tumor growth and metastasis. Streptomyces species, known for their secondary metabolite production, are prime candidates f…

Impact of Israel Palestine War on Indian Economy Open

Eshwar Ege, Shashank Parab, Suyash Bhosale, Pratik Yadav, Shubham Kashid , et al. · 2024

India Imports a large amount of Crude oil than its export to other country fulfills as much as 85% of its energy needs through imports may see a heavier import bill if International crude oil prices keep rising throughout the year If such …

Efective Management Communications: A Study on Traditional Businesses to Accept Digital Marketing Open

Eshwar Ege, Shashank Parab, Shreya Bhosale, Shubham Kashid, Pratik Yadav , et al. · 2024

The main Agenda is to make Traditional Business Accept Digital Marketing showing them how useful online platform is earlier there was no Digital Marketing program was there But afterword’s Digital marketing came into existence After Invent…

CCDC 2254740: Experimental Crystal Structure Determination Open

Pratik Yadav, Sasmita Das, Mariko Saito, T.E. Evans, Bhaskar C. Das · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2254741: Experimental Crystal Structure Determination Open

Pratik Yadav, Sasmita Das, Mariko Saito, T.E. Evans, Bhaskar C. Das · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Study of Lean Technique in Construction Open

Prof. Pradnya Kulkarni, Sanat Dubey, Pratik Yadav, Saurav Wankhede, Pritesh Gaikwad , et al. · 2023

The objective of this analysis is testing the 1. usefulness of some lean construction tools, particularly, all those tools which may be utilized in medium size construction firms. Because of the results of the lean manufacturing process in…

Development of a New Methodology for Dearomative Borylation of Coumarins and Chromenes and Its Applications to Synthesize Boron-Containing Retinoids Open

Bhaskar C. Das, Pratik Yadav, Sasmita Das, Mariko Saito, Todd Evans · 2023

Dearomative borylation of coumarins and chromenes via conjugate addition represents a relatively unexplored and challenging task. To address this issue, herein, we report a new and general copper (I) catalyzed dearomative borylation proces…

EXTH-50. IDENTIFYING TRIM11 AS A POTENTIAL THERAPEUTIC TARGET FOR MALIGNANT GLIOMAS Open

Kaijun Di, Daniela Abrams, Pratik Yadav, Bhaskar C. Das, Daniela A. Bota · 2022

TRIM11 (tripartite motif-containing protein 11) belongs to the TRIM/RBCC (the RING B-box coiled-coil) family of E3 ubiquitin ligases. Members of this family have been implicated in development, neurodegenerative diseases, cellular response…

Review on Case Study of Image Classification using CNN Open

Pratik Yadav, Naveen Madur, Vishwajeet Rajopadhye, Vishwajeet Rajopadhye, Mr. Shrikant Salatogi · 2022

Traditional neural networks though have achieved appreciable performance at image classification, they have been characterized by feature engineering, a tedious process that results in poor generalization to test data. In this report, we p…

A novel procedure for the synthesis of borylated quinolines and its application in the development of potential boron-based homeodomain interacting protein kinase 2 (HIPK2) inhibitors Open

Bhaskar C. Das, Pratik Yadav, Sasmita Das, John Cijiang He · 2022

This report reveals a Pd catalyzed C-4 borylation of structurally complex chloroquinolines with B 2 (pin) 2 without the use of any external ligand for the synthesis of potential boron-based homeodomain interacting protein kinase 2 inhibito…

CCDC 2059201: Experimental Crystal Structure Determination Open

Chandan Shah, Pratik Yadav, Ismail Althagafi, Vishal Nemaysh, Ranjay Shaw , et al. · 2021

Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence Open

Siddhi Bagwe‐Parab, Pratik Yadav, Ginpreet Kaur, Hardeep Singh Tuli, Harpal S. Buttar · 2020

The incidence of gastrointestinal disorders (GID) and cancers is escalating all over the world. Limited consumption of colostrum by newborns not only weakens the immune system but also predisposes infants to microbial infections. Colostrum…

CCDC 1857029: Experimental Crystal Structure Determination Open

Rahul Panwar, Ismail Althagafi, Shally Shally, Ranjay Shaw, Amr Elagamy , et al. · 2020

Redox-Responsive Dipeptide Nanostructures toward Targeted Cancer Therapy Open

Sonika Chibh, Avneet Kour, Nitin Yadav, Pankaj Kumar, Pratik Yadav , et al. · 2020

Materials that exhibit responsiveness toward biological signals are currently subjected to intense research in the field of drug delivery. In our study, we tried to develop cancer-targeted and redox-responsive nanoparticles (NPs) from disu…

CCDC 1520565: Experimental Crystal Structure Determination Open

Pratik Yadav, Ranjay Shaw, Amr Elagamy, Abhinav Kumar, Ramendra Pratap · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1501042: Experimental Crystal Structure Determination Open

Rahul Panwar, Surjeet Singh, Pratik Yadav, Shally Shally, Ranjay Shaw , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1501043: Experimental Crystal Structure Determination Open

Rahul Panwar, Surjeet Singh, Pratik Yadav, Shally Shally, Ranjay Shaw , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1520563: Experimental Crystal Structure Determination Open

Pratik Yadav, Ranjay Shaw, Rahul Panwar, Satya Narayan Sahu, Abhinav Kumar , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

A RARE CASE REPORT: CONGENITAL HYPOFIBRINOGENAEMIA - A NEWBORN INFANT WITH CORD BLEEDING Open

Suryakant Yashwant Ingale, Prashant Popatlal Shah, Raghunandan Reddy Bheem Reddy, Pulkit Devrajbhai Sheta, Pratik Yadav · 2016

The genetic disorders causing decreased fibrinogen synthesis may be caused by heterozygous (hypofibrinogenaemia) or homozygous (afibrinogenaemia) deficiency. 1 The consequences of the disorders are gastrointestinal bleeding, cord bleeding,…

A RARE CASE REPORT: MAPLE SYRUP URINE DISEASE Open

Suryakant Yashwant Ingale, Prashant Popatlal Shah, Pratik Yadav, Harshada Tatiya, Raghunandan Reddy Bheem Reddy · 2016

We report a case of Maple Syrup Urine Disease presenting in an 8-day-old neonate with classic MRI & biochemical findings.MSUD is a rare autosomal recessive inborn error of metabolism.Its incidence is estimated to be around 1 in 185,000 inf…

ATAXIA TELANGIECTASIA: A RARE CASE REPORT Open

Suryakant Yashwant Ingale, Pratik Yadav, Lekha Mishra, Akhila Sukumaran · 2016

Ataxia-Telangiectasia (A-T) is a rare hereditary neurodegenerative disorder.Ataxia and telangiectasia are the hallmarks of the disease.Individuals with classic A-T have mutations in ATM, the only gene known to be associated with ataxia tel…

CCDC 1038008: Experimental Crystal Structure Determination Open

Satya Narayan Sahu, Maneesh K. Gupta, Surjeet Singh, Pratik Yadav, Rahul Panwar , et al. · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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