Explanipedia

ADVANCING THE UNDERSTANDING OF CLINICAL SEPSIS USING GENE EXPRESSION–DRIVEN MACHINE LEARNING TO IMPROVE PATIENT OUTCOMES Open

Asrar Rashid, Feras Al‐Obeidat, Wael Hafez, Govind Benakatti, Rayaz A. Malik , et al. · 2023

Sepsis remains a major challenge that necessitates improved approaches to enhance patient outcomes. This study explored the potential of machine learning (ML) techniques to bridge the gap between clinical data and gene expression informati…

A TRANSCRIPTOMIC APPRECIATION OF CHILDHOOD MENINGOCOCCAL AND POLYMICROBIAL SEPSIS FROM A PRO-INFLAMMATORY AND TRAJECTORIAL PERSPECTIVE, A ROLE FOR VASCULAR ENDOTHELIAL GROWTH FACTOR A AND B MODULATION? Open

Asrar Rashid, Berit Brusletto, Feras Al‐Obeidat, Mohammed Toufiq, Govind Benakatti , et al. · 2023

This study investigated the temporal dynamics of childhood sepsis by analyzing gene expression changes associated with proinflammatory processes. Five datasets, including four meningococcal sepsis shock (MSS) datasets (two temporal and two…

Application of a gene modular approach for clinical phenotype genotype association and sepsis prediction using machine learning in meningococcal sepsis Open

Asrar Rashid, Arif Reza Anwary, Feras Al‐Obeidat, Joe Brierley, Mohammed Uddin , et al. · 2023

Sepsis is a major global health concern causing high morbidity and mortality rates. Our study utilized a Meningo- coccal Septic Shock (MSS) temporal dataset to investigate the correlation between gene expression (GE) changes and clinical f…

Sepsis Transcriptomic Trajectory and Phenotypic Correlation Using Time Series Gene Expression from Childhood Meningococcal Infection Open

Asrar Rashid, Mohammed Toufiq, Praveen Khilnani, Zainab Malik, Zain Hussain , et al. · 2022

Sepsis remains a leading cause of in-hospital morbidity and mortality. In the acute phase sepsis is described as a dysregulated process. The objective was to track temporal transcriptomic changes in infants with meningococcal disease (MSS)…

Applying Transcriptomics for an Enhanced Clinical Research Framework, Implications for an Improved Research Strategy based on an Omics Approach: A Scoping Review Open

Asrar Rashid, Feras Al-Obeida, Hari P. Krishnan, Govind Benakatti, Wael Hafez , et al. · 2022

Sepsis remains a major global health issue in pediatric and adult populations, largely due to a lack of understanding of its complex pathophysiology. Despite its high mortality rate, there have been few advancements in sepsis-specific ther…

VEGF subtype A and B Gene Expression, Clues to a Temporal Signature in Kawasaki Disease, Implications for Coronary Pathogenesis through a Secondary analysis of Clinical Datasets Open

Asrar Rashid, Mohammed Toufiq, Praveen Khilnani, Zainab Malik, Javed Sharief , et al. · 2022

Background and Aim An essential issue for Kawasaki Disease (KD) is the development of coronary artery disease. We decided to investigate (VEGF) subtype gene expression in KD due to the proangiogenic nature of Vasoactive Endothelial Growth …

Successful management of acquired pinhole subglottic stenosis by multidisciplinary pediatric airway team Open

Praveen Khilnani, Chandrashekhar Singha, Ankur Ohri, Rakhee Goyal, Shandip Kumar Sinha , et al. · 2021

The concept of neonatal and pediatric airway team is somewhat new in India. : In Western countries, though this concept has been established recently, it remains only limited to children's hospitals. We report the case of a 15-month-old gi…

Gastrointestinal Issues in Critically Ill Children Open

Praveen Khilnani, Nidhi Rawal · 2020

Due to lack of uniform diagnostic criteria, gastrointestinal (GI) complications in critically ill occur with variable frequency,¹ and overall incidence of such complications seems to be less in children compared to adults. Major…

Consensus Guidelines for Pediatric Intensive Care Units in India, 2020 Open

Praveen Khilnani, Bala Ramachandran, Farhan Shaikh, Rachna Sharma, Anil Sachdev , et al. · 2020

PICU quiz Open

Pradeep Sharma, Praveen Khilnani · 2020

PICU quiz Open

Pradeep Sharma, Praveen Khilnani · 2020

PICU quiz Open

Pradeep Sharma, Praveen Khilnani · 2020

First line vasoactive therapy after fluid resuscitation in pediatric septic shock – Dopamine, Adrenaline or Noradrenaline? Open

Praveen Khilnani, Mehak Bansal · 2019

Severe sepsis and septic shock are the leading cause of morbidity and mortality in children all over the world, in both developed and developing nations. Surviving Sepsis Guidelines 2016 have recommended norepinephrine as the first choice …

Pediatric Critical Care Medicine Training in India: Past, Present, and Future Open

Utpal Bhalala, Praveen Khilnani · 2018

Pediatric critical care services in India have grown with leaps and bounds. There has been a growing need of physicians specially trained in pediatric critical care medicine (PCCM) in India. Physicians returning to India after their formal…

A rare presentation of refractory seizures in a case of Hypomagnesemia With Secondary Hypocalcaemia (HSH) caused by a novel TRPM6 gene mutation Open

Naresh Lal, Rachna Sharma, Praveen Khilnani · 2018

A 1.8 year old male child born of a non-consanguineous marriage presented with loose stools and refractory seizures. He had severe hypomagnesemia (0.36mg/dl) with hypocalcaemia (4.8mg/dl,iCa 0.4mmol/l). Vitamin D (28 ng/ml) level was sligh…

Anticoagulation on extracorporeal membrane oxygenation (ECMO) Open

Praveen Khilnani · 2017

Introduction: Extracorporeal circulation has been around for more than half a century, but many questions remain regarding how to best achieve anticoagulation in a patient on extracorporeal membrane oxygenation (ECMO). Although unfractiona…

Adrenal dysfunction in critical care settings Open

Vinayak Patki, Praveen Khilnani, Frederick J. Zimmerman · 2017

Adrenal insufficiency (AI) is a frequently discussed but inadequately understood condition among critically ill patients. Increased glucocorticoid action is an essential component of the stress response. Dysfunction of the HPA axis in crit…

Traumatic brain injury in PICU Open

Febna Rahiman, Rakshay Shetty, Praveen Khilnani · 2017

Traumatic brain injuries (TBI) and its complications are a leading cause of morbidity, mortality, disability and socioeconomic losses in India and other developing countries. Especially in children it poses a significant global public heal…

Guest editorial pediatric trauma, it is time to act Open

Praveen Khilnani, Geethanjali Ramachandra · 2017

Common problems and troubleshooting on ECMO run Open

Rachna Sharma, Praveen Khilnani · 2017

The technological advances in ECMO have changed to enhance safety, accessibility and facilitate its use, contributing to decreased morbidity and improved survival of patients requiring ECMO support. Major advances in ECMO deployment parall…

Traumatic brain injury in PICU Open

Rakshay Shetty, FebnaA Rahiman, Praveen Khilnani · 2017

Sick euthyroid syndrome: A myth or reality Open

Vinayak Patki, Aniket Kumbhojkar, Praveen Khilnani · 2017

Altered thyroid function in non-thyroidal illness(NTI) is a well-recognized finding. The term euthyroid sick syndrome (SES) identifies abnormalities in thyroid function observed in patients with systemic nonthyroidal illnesses (NTIs). SES …

ECMO extra corporeal membrane oxygenation guest editorial Open

Praveen Khilnani, Suneel Pooboni · 2017

In today's world of critical care medicine, Extra Corporeal Life Support (ECLS/ECMO) is an extension to the current practices of life support such as ventilator care and inotropic use providing cardio respiratory support. When the failing …

PICU quiz Open

Praveen Khilnani · 2017

Medical management and perioperative issues in pediatric pheochromocytoma – A case report with review of literature Open

Naresh Lal, Ankur Ohri, Vibinkumar Vasudevan, Rachna Sharma, Praveen Khilnani · 2017

Pheochromocytoma is a tumor arising out of embryological neural crest, being a tumor of adrenal medulla secreting predominantly norepinephrine as well as epinephrine(about 20% cases) leading to frequent surges of vasopressor catecholamines…

Extracorporeal membrane oxygenation: A review Open

Praveen Khilnani · 2017

Extracorporeal membrane oxygenation (ECMO) is used to support heart and lungs for extended periods of time till the underlying disease process is treated by use of a semi permeable membrane oxygenator .In 70s ECMO as a treatment modality i…

Clinical management of diabetic ketoacidosis Open

Asrar Rashid, Sanjay Perkar, Praveen Khilnani, Sarah Ehtisham · 2017

Diabetic Ketoacidosis (DKA) is a commonly seen condition in Pediatric age group requiring admission to the PICU. The scope of this article is to discuss the management of children with moderate to severe DKA requiring hospital- ization. El…

Guest editorial pediatric trauma, it is time to act Open

Praveen Khilnani, Geethanjali Ramachandra · 2017

Journal scan Open

Naresh Lal, Rachna Sharma, Praveen Khilnani · 2017

JOURNAL OF PEDIATRIC CRITICAL CARE Open

Suneel Pooboni, Praveen Khilnani · 2017

Praveen Khilnani YOU? Author Swipe