Praveen Kumar Sappa
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View article: Impact of high salinity and the compatible solute glycine betaine on gene expression of <i>Bacillus subtilis</i>
Impact of high salinity and the compatible solute glycine betaine on gene expression of <i>Bacillus subtilis</i> Open
Summary The Gram‐positive bacterium Bacillus subtilis is frequently exposed to hyperosmotic conditions. In addition to the induction of genes involved in the accumulation of compatible solutes, high salinity exerts widespread effects on B.…
View article: Analyses of competent and non‐competent subpopulations of <i>Bacillus subtilis</i> reveal <scp> <i>yhfW</i> </scp> , <scp> <i>yhxC</i> </scp> and <scp>ncRNAs</scp> as novel players in competence
Analyses of competent and non‐competent subpopulations of <i>Bacillus subtilis</i> reveal <span> <i>yhfW</i> </span> , <span> <i>yhxC</i> </span> and <span>ncRNAs</span> as novel players in competence Open
Summary Upon competence‐inducing nutrient‐limited conditions, only part of the Bacillus subtilis population becomes competent. Here, we separated the two subpopulations by fluorescence‐assisted cell sorting (FACS). Using RNA‐seq, we confir…
View article: Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72
Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72 Open
Type VI protein secretion systems (T6SSs) have been identified in many plant-associated bacteria. However, despite the fact that effector proteins may modulate host responses or interbacterial competition, only a few have been functionally…
View article: Large-scale reduction of the <i>Bacillus subtilis</i> genome: consequences for the transcriptional network, resource allocation, and metabolism
Large-scale reduction of the <i>Bacillus subtilis</i> genome: consequences for the transcriptional network, resource allocation, and metabolism Open
Understanding cellular life requires a comprehensive knowledge of the essential cellular functions, the components involved, and their interactions. Minimized genomes are an important tool to gain this knowledge. We have constructed strain…
View article: Brain Derived Neurotrophic Factor Contributes to the Cardiogenic Potential of Adult Resident Progenitor Cells in Failing Murine Heart
Brain Derived Neurotrophic Factor Contributes to the Cardiogenic Potential of Adult Resident Progenitor Cells in Failing Murine Heart Open
Comparative profiling of resident Sca-1 cells revealed elevated BDNF levels in the failing heart. Exogenous BDNF (i) stimulated migration, which might improve the homing ability of Sca-1 cells derived from the failing heart and (ii) repres…