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View article: Evaluation of the wound healing and anti-microbial activity of hydroethanolic extracts of young and old leaves of Vernonia amygdalina Delile
Evaluation of the wound healing and anti-microbial activity of hydroethanolic extracts of young and old leaves of Vernonia amygdalina Delile Open
Background: Vernonia amygdalina Delile (VA) has been reported as an important herb for the management of wound in traditional medical settings. However, the evaluation of the wound healing and antimicrobial effect of the young and old leav…
View article: Coronavirus disease 2019 (COVID-19) vaccine acceptability in Ghana: An urban-based population study
Coronavirus disease 2019 (COVID-19) vaccine acceptability in Ghana: An urban-based population study Open
Introduction Coronavirus disease 2019 (COVID-19) vaccine hesitancy is a complex health challenge characterized by a delay in the acceptance or refusal of the vaccination with context-specific determinants. Our study, therefore, assessed th…
View article: Effect of ‘Galamsey’ on Human Fertility: A Systematic Review
Effect of ‘Galamsey’ on Human Fertility: A Systematic Review Open
Background and Aims In Ghana, the term ‘galamsey’ refers to illicit small‐scale gold mining. It is a primary factor in water pollution, land degradation and other environmental harm. It has also been connected to health risks like displace…
View article: Insight into the immunomodulatory and chemotherapeutic mechanisms of paeonol (Review)
Insight into the immunomodulatory and chemotherapeutic mechanisms of paeonol (Review) Open
Paeonol a, pharmacologically active constituent obtained from the root bark of Paeonia suffruticosa has been extensively utilized as a traditional Chinese medicine for the treatment, prevention and control of several diseases for years. Pa…
View article: Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana
Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana Open
Background Head and neck tumors (HNT) are tumors of the paranasal sinuses, the salivary glands and the upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties and has been implicated in a number of c…
View article: Prognostic Significance of Nuclear Factor Kappa B (p65) among Breast Cancer Patients in Cape Coast Teaching Hospital
Prognostic Significance of Nuclear Factor Kappa B (p65) among Breast Cancer Patients in Cape Coast Teaching Hospital Open
Breast cancer is the most prevalent cancer among African women, with high mortality rates in Ghana. Nuclear factor kappa B (NF-kB) has been associated with tumor progression in breast cancer. However, its clinical validation is controversi…
View article: 23 Expression of Ras and Rab interactor 1 (Rin1) and Notch1 in head and neck tumours at selected hospitals in Ghana
23 Expression of Ras and Rab interactor 1 (Rin1) and Notch1 in head and neck tumours at selected hospitals in Ghana Open
Background Head and neck tumors (HNT) are of paranasal sinuses origin (the salivary glands and the upper aerodigestive tract). It constitutes the sixth most common tumors. Studies have shown that, factors such as tobacco and alcohol intak…
View article: Prognostic Worth of Nrf2/BACH1/HO-1 Protein Expression in the Development of Breast Cancer
Prognostic Worth of Nrf2/BACH1/HO-1 Protein Expression in the Development of Breast Cancer Open
Objectives: Nrf2/BACH1/HO-1 proteins have been implicated in the development and progression of tumors. However, their clinical relevance in breast cancer remains unclear and understudied. This study evaluated Nrf2/BACH1/HO-1 protein expre…
View article: The Interactive Role of Macrophages in Innate Immunity
The Interactive Role of Macrophages in Innate Immunity Open
Macrophages are critical effector cells of the innate immune system that play central roles in the initiation and resolution of inflammation. They mediate resistance in response to pathogens and “danger” signals mainly through phagocytosis…
View article: Efficacy of combined antioxidant therapy in male subfertility-A systematic review and meta-analysis
Efficacy of combined antioxidant therapy in male subfertility-A systematic review and meta-analysis Open
Antioxidant therapy is a potentially promising approach to improve clinical outcomes for couples undergoing assisted reproduction techniques long-term. The review aims to (a) collate evidence for the effectiveness of combined oral antioxid…
View article: A Review: Mechanism of Phyllanthus urinaria in Cancers—NF-κB, P13K/AKT, and MAPKs Signaling Activation
A Review: Mechanism of Phyllanthus urinaria in Cancers—NF-κB, P13K/AKT, and MAPKs Signaling Activation Open
Phyllanthus urinaria has been characterized for its several biological and medicinal effects such as antiviral, antibacterial, anti-inflammatory, anticancer, and immunoregulation. In recent years, Phyllanthus urinaria has demonstrated pote…
View article: Cardioprotective role of myocardial endothelial nitric oxide synthase and serum nitric oxide induced by hexarelin in rats with myocardial infarction-induced heart failure
Cardioprotective role of myocardial endothelial nitric oxide synthase and serum nitric oxide induced by hexarelin in rats with myocardial infarction-induced heart failure Open
Background: Growth hormone-releasing peptides (GHRP) have been reported to possess cardioprotective properties; nonetheless, their mechanisms of action are still not very clear. Objectives: Some studies have suggested that modulation of en…
View article: Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens
Effect of hookworm infection and anthelmintic treatment on naturally acquired antibody responses against the GMZ2 malaria vaccine candidate and constituent antigens Open
Background Malaria and helminths diseases are co-endemic in most parts of sub-Saharan Africa. Immune responses from each of these pathogens interact, and these interactions may have implications on vaccines. The GMZ2 malaria vaccine candid…
View article: Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors
Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors Open
Introduction. Head and neck tumors (HNT) are tumors that normally occur at the head and neck region of the body. Epidermal growth factor receptor (EGFR) has been found to be highly expressed in breast and other tumors; therefore, there is …
View article: Ameliorative Effect of <i>Vernonia amygdalina</i> Plant Extract on Heavy Metal-Induced Liver and Kidney Dysfunction in Rats
Ameliorative Effect of <i>Vernonia amygdalina</i> Plant Extract on Heavy Metal-Induced Liver and Kidney Dysfunction in Rats Open
Heavy metal toxicity contributes to liver and kidney dysfunction and damage through oxidative stress mechanisms; however, from previous studies, extracts from the Vernonia amygdalina plant have shown to possess potent antioxidant propertie…
View article: PROGNOSTIC SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN HEAD AND NECK TUMOURS AT SOME SELECTED HOSPITAL IN GHANA
PROGNOSTIC SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN HEAD AND NECK TUMOURS AT SOME SELECTED HOSPITAL IN GHANA Open
Abstract: Background: Head and neck Tumour (HNT) are tumour of the paranasal sinuses, the salivary glands and the upper aero¬digestive tract. EGF can stimulate cell proliferation, cell differentiation, cell growth, migration, and inhibit a…
View article: Necator Americanus and Plasmodium Falciparum Co-Infection and Albendazole Treatment Outcome among Individuals in Rural Ghana
Necator Americanus and Plasmodium Falciparum Co-Infection and Albendazole Treatment Outcome among Individuals in Rural Ghana Open
scale treatment with benzimidazole has raised concerns about the possible emergence of resistance and decreased treatment efficacy has been reported in some studies (Albonico et al., 2004; Keiser and Utzinger, 2008).Helminth infections in …
View article: Corrigendum to “Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of <i>Vernonia amygdalina</i>: A Comparative Study”
Corrigendum to “Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of <i>Vernonia amygdalina</i>: A Comparative Study” Open
[This corrects the article DOI: 10.1155/2016/8252741.].
View article: Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of<i>Vernonia amygdalina</i>: A Comparative Study
Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of<i>Vernonia amygdalina</i>: A Comparative Study Open
The young leaves of Vernonia amygdalina are often utilized as vegetable and for medicinal purpose compared to the old leaves. This study was designed to evaluate and compare the antidiabetic effects between ethanolic leaf extracts of old a…