Prem Shekar
YOU?
Author Swipe
View article: Phytochemical Screening and Cytotoxic Potential of Lantana camara Leaf Extract against MCF-7 Cells: A Cell Morphology and MTT Assay Approach
Phytochemical Screening and Cytotoxic Potential of Lantana camara Leaf Extract against MCF-7 Cells: A Cell Morphology and MTT Assay Approach Open
Objective: The present study aimed to evaluate the cytotoxic potential of Lantana camara leaf extract against MCF-7 human breast cancer cells using the MTT assay and morphological analysis. Methods: Dried leaves of Lantana camara were extr…
View article: Hypothermic Low Flow Fibrillation for Unclampable Aorta in Coronary Artery Bypass Grafting: Alternative to Off‐Pump CABG
Hypothermic Low Flow Fibrillation for Unclampable Aorta in Coronary Artery Bypass Grafting: Alternative to Off‐Pump CABG Open
Background: Severe calcific disease of the ascending aorta may prohibit cross‐clamping during coronary artery bypass grafting (CABG) due to unacceptable morbidity and mortality associated with atheroembolic complications. Clampless hypothe…
View article: Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery
Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery Open
Objectives It is uncertain whether concurrent mitral valve repair or replacement for moderate or greater secondary mitral regurgitation at the time of coronary artery bypass graft or aortic valve replacement surgery improves long-term surv…
View article: Transcatheter Compared With Surgical Aortic Valve Replacement in Patients With Previous Chest-Directed Radiation Therapy
Transcatheter Compared With Surgical Aortic Valve Replacement in Patients With Previous Chest-Directed Radiation Therapy Open
TAVR was associated with excellent in-hospital outcomes and better survival compared with intermediate-/high-risk SAVR in patients with CRT-AS. While SAVR still has a role in low-risk patients or those for whom TAVR is unsuitable for techn…
View article: Appreciation to Reviewers in 2020
Appreciation to Reviewers in 2020 Open
AORTA would like to thank the following reviewers for their contribution and support as expert peer reviewers of submitted scientific papers in 2020. Your efforts, insight, and judgment are greatly appreciated. Thank you for your contribut…
View article: Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality Open
OBJECTIVES Functional mitral regurgitation (MR) is observed with ischaemic heart disease or aortic valve disease. Assessing the value of mitral valve repair or replacement (MVR/P) is complicated by frequent discordance between preoperative…
View article: Systemic Allergic Contact Dermatitis Due to a GORE CARDIOFORM Septal Occluder Device
Systemic Allergic Contact Dermatitis Due to a GORE CARDIOFORM Septal Occluder Device Open
Nickel hypersensitivity is a rarely reported complication of percutaneous patent foramen ovale/atrial septal defect closure. Herein, we report a case of systemic allergic contact dermatitis to nickel present in a GORE CARDIOFORM (W.L. Gore…
View article: Long-Term Outcomes of Right Minithoracotomy Versus Hemisternotomy for Mitral Valve Repair
Long-Term Outcomes of Right Minithoracotomy Versus Hemisternotomy for Mitral Valve Repair Open
Objective Minimally invasive mitral valve repair has been increasingly adopted. Right minithoracotomy (RT) and lower hemisternotomy (HS) have each been associated with improved short-term outcomes; however, these approaches have not been d…
View article: Outside Facility Transfer Is Associated With Frequent Disposition to Rehabilitation Following Transcatheter Aortic Valve Replacement
Outside Facility Transfer Is Associated With Frequent Disposition to Rehabilitation Following Transcatheter Aortic Valve Replacement Open
Significant variability exists in disposition practices to non-home facilities following transcatheter aortic valve replacement (TAVR). Increased spending due to Post Acute Care Transfer (PACT) policies has led hospitals to scrutinize pati…
View article: The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human
The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human Open
Our data from analysis of human hearts as well as functional in vitro studies strongly suggests that the loss of cardiac endogenous Klotho in CKD patients, specifically in cardiomyocytes, facilitates intensified TGF-β1 signaling which enab…
View article: Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation
Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation Open
Background: The CTSN (Cardiothoracic Surgical Trials Network) recently reported no difference in left ventricular end-systolic volume index or in survival at 2 years between patients with severe ischemic mitral regurgitation (MR) randomize…
View article: Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique
Early and Midterm Outcomes of Valve-Sparing Aortic Root Replacement—Reimplantation Technique Open
Background Valve-sparing aortic root replacement (VSARR) is an increasingly popular alternative to traditional aortic root replacement for aortic root aneurysm disease with a normal aortic valve. We evaluated the early and midterm outcomes…