Padmaja Subbarao
YOU?
Author Swipe
View article: RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood
RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood Open
Genetic variation and environmental exposures are amongst the main factors associated with inter-individual DNA methylation variability. However, the prevalence and genomic context of individual, additive, and interactive gene-environment …
View article: Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies Open
Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these chemicals diff…
View article: Quantifying the impact of early life growth adversity on later life health
Quantifying the impact of early life growth adversity on later life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
Caregiver perspectives on feeding and swallowing difficulties in children with developmental disabilities in India Open
Background Understanding pediatric feeding and swallowing disorders from the caregiver’s point of view is essential for effective intervention. This understanding can be suitably gained using qualitative methods. Thus, the present study ai…
View article: Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD cohort study
Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD cohort study Open
Introduction Human milk fatty acids and human milk oligosaccharides (HMOs) are milk components inconsistently associated with neurodevelopment. The objective of this research is to examine the link between fatty acids, HMOs and neurodevelo…
Leveraging artificial intelligence for the management of preschool wheeze: A narrative review Open
Management of preschool wheeze is notoriously challenging given heterogeneous clinical trajectories and underlying biological mechanisms dictating therapeutic response. Data‐driven approaches have highlighted the value of identifying indiv…
View article: Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy
Exposure to maternal human milk components interacts with infant polygenic risk to predict childhood atopy Open
Although human milk (HM) is known to benefit infant health, how its many bioactive components (e.g., microbiota (HMM), oligosaccharides (HMOs), and fatty acids (HMFAs)) influence the risk of childhood atopy remains poorly understood. Our s…
View article: Infant Acid‐Suppressant Medication, <scp> <i>C. difficile</i> </scp> Colonisation, and Childhood Body Mass Index in a Canadian Cohort
Infant Acid‐Suppressant Medication, <span> <i>C. difficile</i> </span> Colonisation, and Childhood Body Mass Index in a Canadian Cohort Open
Aim To determine relationships between paediatric use of acid‐suppressive medications (ASMs) (proton pump inhibitors (PPI) and histamine‐2 receptor antagonists (H2RA)) and preschool body mass index (BMI) and mediation by C. difficile colon…
View article: Human milk IgA promotes normal immune development by limiting Th17-inducing <i>Erysipelatoclostridium ramosum</i> in the infant gut
Human milk IgA promotes normal immune development by limiting Th17-inducing <i>Erysipelatoclostridium ramosum</i> in the infant gut Open
The gut microbiota is highly dynamic during the first year of life and plays a crucial role in immune development. Breastfeeding is known to support infant health, but the contributions of the numerous breastmilk components to gut microbio…
View article: Breastfeeding limits the adverse impact of socioeconomic status on child health by modifying the infant gut microbiome
Breastfeeding limits the adverse impact of socioeconomic status on child health by modifying the infant gut microbiome Open
Lower familial socioeconomic status (SES) is linked to increased childhood disease risk. Since SES has no inherent biological basis, identifying how it becomes physiologically embedded is essential for equitable intervention. Using data fr…
View article: Associations of dietary patterns and obesity development in school‐aged children: results from the <scp>CHILD</scp> Cohort Study
Associations of dietary patterns and obesity development in school‐aged children: results from the <span>CHILD</span> Cohort Study Open
Objective We aimed to understand data‐driven dietary patterns in Canadian preschoolers and their impact on obesity development among male and female individuals. Methods In the prospective, population‐based Canadian pregnancy cohort, the C…
View article: Quantifying the impact of early-life growth adversity on later-life health
Quantifying the impact of early-life growth adversity on later-life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
An Update on Biologics in Pediatric Asthma: A Canadian Perspective Open
Asthma is one of the most common chronic diseases in Canada, affecting approximately 11% of Canadians. Severe asthma, estimated to affect 5–10% of patients with asthma, is associated with a significant burden of disease‑related morbidity. …
View article: Maternal Profiles Account for Birth Weight Differences Across Ethnicities: Results from Three Canadian Birth Cohorts
Maternal Profiles Account for Birth Weight Differences Across Ethnicities: Results from Three Canadian Birth Cohorts Open
Background Marked differences in birth weight (BW) between South Asian and White European-origin populations are well-documented and pose public health concerns. Methods We analyzed fetal BW, the fat mass (FM), and fat-free mass (FFM) comp…
View article: RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood
RAMEN: Dissecting individual, additive and interactive gene-environment contributions to DNA methylome variability in cord blood Open
DNA methylation (DNAme) is the most commonly studied epigenetic mark in human populations. DNAme has gained attention in the Developmental Origins of Health and Disease field due to its gene expression regulation and potential long-term st…
View article: Advancing Pediatric and Longitudinal DNA Methylation Studies with CellsPickMe, an Integrated Blood Cell Deconvolution Method
Advancing Pediatric and Longitudinal DNA Methylation Studies with CellsPickMe, an Integrated Blood Cell Deconvolution Method Open
Prospective birth cohorts offer the potential to interrogate the relation between early life environment and embedded biological processes such as DNA methylation (DNAme). These association studies are frequently conducted in the context o…
View article: Early life predictors of child development at kindergarten: a structural equation model using a longitudinal cohort
Early life predictors of child development at kindergarten: a structural equation model using a longitudinal cohort Open
Introduction Early child development sets the stage for lifelong health. Identifying early life factors related to child development can help guide programs and policies to bolster child health and wellbeing. The objective of this research…
View article: Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies
Phthalates, Bisphenols, and Childhood Allergic Phenotypes: Findings from Two Birth Cohort Studies Open
Background Phthalates and bisphenols may contribute to childhood allergic outcomes, but whether these are differentially associated with atopic or non-atopic phenotypes is uncertain. We investigated whether early-life exposure to these che…
View article: Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze
Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze Open
Aims Wheezing in childhood is common and evidence is accumulating for the role of the gut microbiome in the development of atopic wheeze. Changes to the early-life gut microbiota and secretory IgA (SIgA) production have been linked to chil…
View article: Ultraprocessed Food Consumption and Obesity Development in Canadian Children
Ultraprocessed Food Consumption and Obesity Development in Canadian Children Open
Importance Ultraprocessed foods (UPF), characterized as shelf-stable but nutritionally imbalanced foods, pose a public health crisis worldwide. In adults, UPF consumption is associated with increased obesity risk, but findings among childr…
View article: Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study
Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study Open
Objective Lower respiratory tract infections (LRTIs) in early life are one of the strongest risk factors for childhood asthma and are often treated with systemic antibiotics (IV or oral). We aimed to explore the association between early-l…
Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children Open
Early-life exposure to pets and related biological agents may modify the associations between phthalates and asthma and wheeze in children. Heterogeneity in single exposure studies could be a result of differences in co-exposures among stu…
View article: Urban environment during pregnancy, cognitive abilities, motor function, and externalizing and internalizing symptoms at 2–5 years old in 3 Canadian birth cohorts
Urban environment during pregnancy, cognitive abilities, motor function, and externalizing and internalizing symptoms at 2–5 years old in 3 Canadian birth cohorts Open
We found no evidence of a relationship of prenatal built environment, surrounding greenness, and air pollution with cognitive abilities, motor functions or externalizing and internalizing symptoms in childhood. Urban environment has been s…
View article: Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system
Biological sex impacts immune cell proportions and epigenetic profiles in the developing pediatric immune system Open
Age- and sex-related differences in immune cell compositions and immune outcomes have been identified in adult and aging populations, but a comprehensive and nuanced characterization of these changes during the rapid developmental window o…
Early Life Predictors of Child Development at Kindergarten: A Structural Equation Model using a Longitudinal Cohort Open
Introduction Early child development sets the stage for lifelong health. Identifying early life factors related to child development can help guide programs and policies to bolster child health and wellbeing. The objective of this research…