Premalatha Paulsamy
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View article: Dose-Sparing Efficacy of d-Limonene with Low-Dose Allopurinol in a Dual Model of Hyperuricemia and Gouty Arthritis in Rats
Dose-Sparing Efficacy of d-Limonene with Low-Dose Allopurinol in a Dual Model of Hyperuricemia and Gouty Arthritis in Rats Open
Background: d-Limonene (LIM) is a food-derived monoterpenoid phytocompound predominantly found in citrus peels, endowed with potent antioxidant and anti-inflammatory properties, and has been reported to inhibit xanthine oxidase (XO) activi…
View article: Cyanobacteria-Derived Extracellular Vesicles: A Novel Frontier in Drug Delivery and Therapeutics
Cyanobacteria-Derived Extracellular Vesicles: A Novel Frontier in Drug Delivery and Therapeutics Open
Cyanobacteria, known for their diverse and potent bioactive compounds, present a unique method for drug delivery via their extracellular vesicles (EVs), often described as exosome-like due to size and function but distinct in biogenesis. T…
View article: Wound-Healing Efficacy of Daucus carota Bioactive Compounds: Targeting Oxidative Stress, Inflammation, and Apoptosis
Wound-Healing Efficacy of Daucus carota Bioactive Compounds: Targeting Oxidative Stress, Inflammation, and Apoptosis Open
Background/Objectives: Carrot seed essential oil (CSEO) from Daucus carota is rich in sesquiterpenoids and oxygenated sesquiterpenoids known for anti-inflammatory and antioxidant activities. This study evaluated the wound-healing potential…
View article: Targeting Hyperuricemia and NLRP3 Inflammasome in Gouty Arthritis: A Preclinical Evaluation of Allopurinol and Disulfiram Combination Therapy
Targeting Hyperuricemia and NLRP3 Inflammasome in Gouty Arthritis: A Preclinical Evaluation of Allopurinol and Disulfiram Combination Therapy Open
Background/Objectives: Gouty arthritis (GA) is a chronic inflammatory condition characterized by hyperuricemia and NLRP3 inflammasome activation, leading to joint damage and systemic inflammation. Although allopurinol (ALP), a xanthine oxi…
View article: SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights
SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights Open
Cellular senescence regulates aging, tissue maintenance, and disease progression through the Senescence-Associated Secretory Phenotype (SASP), a secretory profile of cytokines, chemokines, growth factors, and matrix-remodeling enzymes. Whi…
View article: Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer Therapy
Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer Therapy Open
Pharmacogenomics is revolutionizing precision medicine by enabling tailored therapeutic strategies based on an individual genetic and molecular profile. Circular RNAs (circRNAs), a distinct subclass of endogenous non-coding RNAs, have rece…
View article: Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges
Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges Open
Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked by significant therapeutic gaps and high unmet…
View article: A Cross‐Sectional Study on Nurse‐Parent Partnership in the Pediatric Intensive Care Units
A Cross‐Sectional Study on Nurse‐Parent Partnership in the Pediatric Intensive Care Units Open
Aims and Objectives . Admission in the intensive care unit is highly stressful, for both the child and family. This study aimed to identify the factors influencing the nurse‐parent partnership in the pediatric intensive care units. Methods…
View article: Parental health-seeking behavior on self-medication, antibiotic use, and antimicrobial resistance in children
Parental health-seeking behavior on self-medication, antibiotic use, and antimicrobial resistance in children Open
The findings indicated that the majority of parents had unfavorable views and improper practices of antibiotic usage. Strategic education programs to the targeted population, especially to the parents about side effects of antibiotics, dan…
View article: Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an Antidepressant Drug
Formulation of Intranasal Mucoadhesive Thermotriggered In Situ Gel Containing Mirtazapine as an Antidepressant Drug Open
The purpose of the present work was to develop nanoemulsion-based formulations of mirtazapine for intranasal delivery using a spray actuator to target the brain for treating depression. Research on the solubility of medications in differen…
View article: Cardiovascular Disease-Related Health Promotion and Prevention Services by Pharmacists in Saudi Arabia: How Well Are They Prepared?
Cardiovascular Disease-Related Health Promotion and Prevention Services by Pharmacists in Saudi Arabia: How Well Are They Prepared? Open
Background: Cardiovascular diseases (CVDs) have been identified as the leading reason for morbidity and mortality in Saudi Arabia. Pharmacists play a major role in CVD prevention and health promotion. We aimed to assess the knowledge, atti…
View article: Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica
Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica Open
Purpose and Objectives. The quest for psychoactive plants possessing therapeutic potential has evolved emerging interest. Salvadora persica (Sp), belonging to the Salvadoraceae family, known as miswak, is a medicinal plant; most of its pub…
View article: Evaluation of Health Care Professionals’ Knowledge, Attitudes, and Practice to Prevent the Pandemic Spread of COVID-19: A Questionnaire-Based Cross-Sectional Study from Abha, Saudi Arabia
Evaluation of Health Care Professionals’ Knowledge, Attitudes, and Practice to Prevent the Pandemic Spread of COVID-19: A Questionnaire-Based Cross-Sectional Study from Abha, Saudi Arabia Open
Background: Pharmacists and other healthcare professionals (HCPs) are at risk of transmitting the lethal COVID-19 virus globally and increasing its prevalence. Aim: The aim of this study was to assess knowledge, attitudes, and practices (K…
View article: Effects of bioactive compound, Ginsenoside Rb1 on Burn Wounds Healing In Diabetic Rats: Influencing M1 To M2 Phenotypic Trans
Effects of bioactive compound, Ginsenoside Rb1 on Burn Wounds Healing In Diabetic Rats: Influencing M1 To M2 Phenotypic Trans Open
Panax notoginseng (P.notoginseng) has been used traditionally to treat traumatic injuries.Ginsenoside Rb1, a key active ingredient derived from Panax notoginseng, has received a lot of interest due to its anti-inflammatory, bacteriostatic,…
View article: Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds
Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds Open
Several medicinal plants have the potential to be a promising alternative pharmacological therapy for a variety of human illnesses. Many insects, including mosquitoes, are important vectors of deadly pathogens and parasites, which in the w…
View article: Patient Centered Care and Centeredness Perspective
Patient Centered Care and Centeredness Perspective Open
Background: Patient-centred care (PCC) helps multidisciplinary health teams to follow informed decision-making practices, and improved healthcare treatments are ensured for patients.The need for significant changes in the healthcare system…
View article: Alternate Warm and Cold Therapy (AWCT) on Uricemia, Sleep, Pain, Functional Ability, and Quality of Life (USPFQoL) in Patients with Gout: A Path Forward
Alternate Warm and Cold Therapy (AWCT) on Uricemia, Sleep, Pain, Functional Ability, and Quality of Life (USPFQoL) in Patients with Gout: A Path Forward Open
Objective. To understand the impact of alternate warm and cold therapy (AWCT) on uricemia, sleep, pain, functional ability, and quality of life in gout patients. Methods. A quasiexperimental, nonequivalent control group, pre and posttest d…
View article: Alleviation of neuropathic pain by trazodone in rats
Alleviation of neuropathic pain by trazodone in rats Open
Neuropathic pain is generally characterised by an abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). The present st…
View article: [Retracted] Strategies to Improvise Organ Donor Pool: A Study on the Knowledge, Attitudes, and Performance of Higher Secondary School Teachers Towards the Organ Donation
[Retracted] Strategies to Improvise Organ Donor Pool: A Study on the Knowledge, Attitudes, and Performance of Higher Secondary School Teachers Towards the Organ Donation Open
Introduction . This study aimed to assess higher secondary school teachers’ knowledge, attitude, and performance levels towards organ transplantation and donation (OTD). Teachers have an essential role in giving knowledge to children and t…
View article: Alleviation of neuropathic pain by trazodone in rats
Alleviation of neuropathic pain by trazodone in rats Open
Neuropathic pain is generally characterised by an abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). The present st…
View article: Association of Maternal Observation and Motivation (MOM) Program with m-Health Support on Maternal and Newborn Health
Association of Maternal Observation and Motivation (MOM) Program with m-Health Support on Maternal and Newborn Health Open
Maternal and child nutrition has been a critical component of health, sustainable development, and progress in low- and middle-income countries (LMIC). While a decrement in maternal mortality is an important indicator, simply surviving pre…
View article: Social Support, Self-Care Behaviour and Self-Efficacy in Patients with Type 2 Diabetes during the COVID-19 Pandemic: A Cross-Sectional Study
Social Support, Self-Care Behaviour and Self-Efficacy in Patients with Type 2 Diabetes during the COVID-19 Pandemic: A Cross-Sectional Study Open
Diabetes mellitus is a major public health issue that considerably impacts mortality, morbidity, and healthcare costs worldwide. The COVID-19 pandemic has created havoc in diabetes management, too, like other spectrums of life. A descripti…
View article: School-Based Exercise and Life Style Motivation Intervention (SEAL.MI) on Adolescent’s Cardiovascular Risk Factors and Academic Performance: Catch Them Young
School-Based Exercise and Life Style Motivation Intervention (SEAL.MI) on Adolescent’s Cardiovascular Risk Factors and Academic Performance: Catch Them Young Open
There are shreds of evidence of shared biological mechanisms between obesity and hypertension during childhood intoadulthood, and loads of research literature has proven that it will profoundly cost nations’ economies and health if neglect…
View article: Association of Maternal Observation and Motivation (MOM) Program with M-Health Support on Maternal and Newborn Health
Association of Maternal Observation and Motivation (MOM) Program with M-Health Support on Maternal and Newborn Health Open
Maternal and child nutrition has been a critical component of health, sustainable development, and progress in low- and middle-income countries (LMIC). While a decrement in maternal mortality is an important indicator, simply surviving pre…
View article: IMMUNOMODULATORY Β-GLUCANS ENHANCE THE WOUND HEALING ABILITY OF CHLOROFORM FRACTION OF ACHYRANTHES ASPERA L
IMMUNOMODULATORY Β-GLUCANS ENHANCE THE WOUND HEALING ABILITY OF CHLOROFORM FRACTION OF ACHYRANTHES ASPERA L Open
Introduction: Wound healing is a multifaceted biological process, and diabetic wounds add more complexity to it. In diabetic wounds, the combination of chloroform fractions of Achyranthes aspera L. (A.aspera) leaves with β-Glucans has…
View article: School Based Exercise and Life Style Motivation Intervention (SEAL.MI) on Adolescent's Cardio Vascular Risk Factors and Academic Performance: Catch Them Young
School Based Exercise and Life Style Motivation Intervention (SEAL.MI) on Adolescent's Cardio Vascular Risk Factors and Academic Performance: Catch Them Young Open
There are evidences of shared biological mechanisms between obesity and hypertension during childhood in the adulthood, and loads of research literatures have proven that, it will cost the economies and health of nations profoundly if negl…
View article: Assessment of Psychological Stress among Quarantined COVID-19 Patients
Assessment of Psychological Stress among Quarantined COVID-19 Patients Open
Corona Virus Disease 2019 (COVID-19) has been causing a worldwide pandemic since the end of 2019. This study looked at the mental health of COVID-19 patients who had been quarantined. This cross-sectional study included fifty COVID - 19 pa…
View article: Prevalence of Depression and Its’ Risk Factors among Higher Secondary School Students
Prevalence of Depression and Its’ Risk Factors among Higher Secondary School Students Open
As adolescence is a transitional stage in which a person's physical and psychological development and transformation are limited to the time between puberty and legal adulthood. It is commonly associated with the onset of a variety of ment…