Premila D. Leiphrakpam
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View article: Targeting Akt Signaling Pathway in Cancer: Molecular Mechanisms and Advances in Therapeutic Interventions
Targeting Akt Signaling Pathway in Cancer: Molecular Mechanisms and Advances in Therapeutic Interventions Open
The Akt/PKB (protein kinase B) is a major transducer of the phosphoinositide 3-kinase (PI3K) signaling axis, regulating key cellular processes such as growth, proliferation, apoptosis, survival, and migration in both normal and cancer cell…
View article: Editorial: Emerging relevance of molecular profiling in global cancer research and management
Editorial: Emerging relevance of molecular profiling in global cancer research and management Open
View article: Association Between Rurality of Residence and Initial Stage at Presentation of Oral Cavity and Oropharyngeal Squamous Cell Carcinoma
Association Between Rurality of Residence and Initial Stage at Presentation of Oral Cavity and Oropharyngeal Squamous Cell Carcinoma Open
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View article: Analysis of Female Medical Student Matriculation Into Orthopaedic Surgery Nationally by Medical School
Analysis of Female Medical Student Matriculation Into Orthopaedic Surgery Nationally by Medical School Open
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View article: PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment
PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment Open
In the last decade, pathway-specific targeted therapy has revolutionized colorectal cancer (CRC) treatment strategies. This type of therapy targets a tumor-vulnerable spot formed primarily due to an alteration in an oncogene and/or a tumor…
View article: Incorporation of Simulation in Graduate Medical Education: Historical Perspectives, Current Status, and Future Directions
Incorporation of Simulation in Graduate Medical Education: Historical Perspectives, Current Status, and Future Directions Open
Technological advancement and improved training strategies have transformed the healthcare practice environment in the last few decades. Simulation has evolved as one of the leading training models for the next generation of healthcare pro…
View article: Global Cancer Surgery: pragmatic solutions to improve cancer surgery outcomes worldwide
Global Cancer Surgery: pragmatic solutions to improve cancer surgery outcomes worldwide Open
View article: Intraperitoneal oxygen microbubble therapy: A novel approach to enhance systemic oxygenation in a smoke inhalation model of acute hypoxic respiratory failure
Intraperitoneal oxygen microbubble therapy: A novel approach to enhance systemic oxygenation in a smoke inhalation model of acute hypoxic respiratory failure Open
View article: Colonic oxygen microbubbles augment systemic oxygenation and CO2 removal in a porcine smoke inhalation model of severe hypoxia
Colonic oxygen microbubbles augment systemic oxygenation and CO2 removal in a porcine smoke inhalation model of severe hypoxia Open
Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patients with a reported mortality ra…
View article: Competency-Based Medical Education (CBME): an Overview and Relevance to the Education of Future Surgical Oncologists
Competency-Based Medical Education (CBME): an Overview and Relevance to the Education of Future Surgical Oncologists Open
View article: Colonic Oxygen Microbubbles Augment Systemic Oxygenation and CO<sub>2</sub> Removal in a Porcine Smoke Inhalation Model of Severe Hypoxia
Colonic Oxygen Microbubbles Augment Systemic Oxygenation and CO<sub>2</sub> Removal in a Porcine Smoke Inhalation Model of Severe Hypoxia Open
Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patients with a reported mortality ra…
View article: A novel large animal model of smoke inhalation-induced acute respiratory distress syndrome
A novel large animal model of smoke inhalation-induced acute respiratory distress syndrome Open
View article: Rat model of smoke inhalation-induced acute lung injury
Rat model of smoke inhalation-induced acute lung injury Open
Background Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a lethal disease with limited therapeutic options and an unacceptably high mortality rate. Understanding the complex pathophysiological processes involved in …
View article: A Novel Large Animal Model of Smoke Inhalation-Induced Acute Respiratory Distress Syndrome
A Novel Large Animal Model of Smoke Inhalation-Induced Acute Respiratory Distress Syndrome Open
Background Acute respiratory distress syndrome (ARDS) is multifactorial and can result from sepsis, trauma, or pneumonia, amongst other primary pathologies. It is one of the major causes of death in critically ill patients with a reported …
View article: MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans
MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans Open
View article: Cell death mechanism in an isolated wood smoke inhalation induced-ARDS large animal model
Cell death mechanism in an isolated wood smoke inhalation induced-ARDS large animal model Open
Acute respiratory distress syndrome (ARDS) is a lethal disease condition in critically ill patients with a reported mortality rate reaching 45%. The current treatment modalities available for severe ARDS are invasive and carry significant …
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
In this review, we summarize principles to navigate pa ents with GIST or so ssue sarcoma through the ongoing COVID-19 pandemic.We discuss risk stra fi ca on, the projected burden of resource u liza on, and the use of alternate nonsurgical …
View article: Correlation of PRL3 expression with colorectal cancer progression
Correlation of PRL3 expression with colorectal cancer progression Open
Objectives To evaluate the relationship between phosphatase of regenerating liver 3 (PRL3) expression and clinical outcome in colorectal cancer (CRC). Background PRL3, a protein tyrosine phosphatase functions as one of the key regulatory e…
View article: Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer
Prognostic and therapeutic implications of NHERF1 expression and regulation in colorectal cancer Open
Background Na + /H + exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic target. The current study evaluated the relationship between NHERF1 expression and …
View article: Role of keratan sulfate expression in human pancreatic cancer malignancy
Role of keratan sulfate expression in human pancreatic cancer malignancy Open
View article: Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2018
Meeting Abstracts - Academy of Managed Care Pharmacy Nexus 2018 Open
AMCP Nexus 2018: Preparing for the Next Generation of Care in Orlando, Florida, is expected to attract more than 2,400 managed care pharmacists and other health care professionals who manage and evaluate drug therapies, develop and manage …
View article: TGFβ and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells
TGFβ and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells Open
Aberrant cell survival plays a critical role in cancer progression and metastasis. We have previously shown that ezrin, a cAMP-dependent protein kinase A-anchoring protein (AKAP), is up-regulated in colorectal cancer (CRC) liver metastasis…