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View article: Pharmacological targeting of RIG-I can selectively activate the integrated stress response
Pharmacological targeting of RIG-I can selectively activate the integrated stress response Open
The integrated stress response (ISR) is a eukaryotic stress-responsive signaling pathway that attenuates global protein synthesis while allowing selective translation of specific mRNAs, which together can reestablish homeostasis following …
View article: Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells Open
SUMMARY Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse aspects of mitochondrial biology …
View article: Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity
Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity Open
SUMMARY The NLRP3 inflammasome is a protein complex that promotes pro-inflammatory signaling as part of the innate immune response. Hyperactivation of the NLRP3 inflammasome has been implicated in many inflammatory and neurodegenerative di…
View article: Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation
Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation Open
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders. The integrated stress response …
View article: Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation
Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation Open
Summary Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically-diverse diseases, including many neurodegenerative disorders. The integrated stress r…
View article: Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation
Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation Open
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders. The integrated stress response …
View article: The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome
The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome Open
The NLRP3 inflammasome promotes inflammation in disease, yet the full repertoire of mechanisms regulating its activity is not well delineated. Among established regulatory mechanisms, covalent modification of NLRP3 has emerged as a common …
View article: Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation
Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation Open
SUMMARY Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically-diverse diseases, including many neurodegenerative disorders. The integrated stress r…
View article: The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome
The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome Open
Summary The NLRP3 inflammasome promotes inflammation in disease, yet the full repertoire of mechanisms regulating its activity are not well delineated. Among established regulatory mechanisms, covalent modification of NLRP3 has emerged as …
View article: Recreating Draupadi: A Study of Chitra Banerjee Divakaruni’s The Palace of Illusions
Recreating Draupadi: A Study of Chitra Banerjee Divakaruni’s The Palace of Illusions Open
Mythological retellings have explored those issues of the epics which were submerged in the objective representation of the events. Redefining the existence of the epical characters, these revisionist writings have presented the events fro…
View article: Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation
Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation Open
A persulfide/hydrogen sulfide generation strategy through artificial substrates for 3-mercaptopyruvate sulfurtransferase (3-MST) is reported, which enhances cellular persulfides, attenuates reactive oxygen species (ROS), and alleviates inf…
View article: Small molecule generators of biologically reactive sulfur species
Small molecule generators of biologically reactive sulfur species Open
Reactive sulfur species (RSS) are integral to cellular survival and growth. Here, small molecule generators of RSS are reviewed.