Priscila Ferreira Slepicka
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View article: Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation
Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation Open
The thymus instructs T cell immunity and central tolerance, yet its therapeutic potential remains untapped. The quest to regenerate thymic function for clinical application is lagging while the signals that drive thymic epithelial cell dif…
View article: Sequential Stem Cell–Kidney Transplantation in Schimke Immuno-osseous Dysplasia
Sequential Stem Cell–Kidney Transplantation in Schimke Immuno-osseous Dysplasia Open
Lifelong immunosuppression is required for allograft survival after kidney transplantation but may not ultimately prevent allograft loss resulting from chronic rejection. We developed an approach that attempts to abrogate immune rejection …
View article: Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review
Harnessing Mechanisms of Immune Tolerance to Improve Outcomes in Solid Organ Transplantation: A Review Open
Survival after solid organ transplantation (SOT) is limited by chronic rejection as well as the need for lifelong immunosuppression and its associated toxicities. Several preclinical and clinical studies have tested methods designed to ind…
View article: The molecular basis of mammary gland development and epithelial differentiation
The molecular basis of mammary gland development and epithelial differentiation Open
Our understanding of the molecular events underpinning the development of mammalian organ systems has been increasing rapidly in recent years. With the advent of new and improved next-generation sequencing methods, we are now able to dig d…
View article: Additional file 2 of NEK10 interactome and depletion reveal new roles in mitochondria
Additional file 2 of NEK10 interactome and depletion reveal new roles in mitochondria Open
Additional file 2: Table S1. NEK10 protein interactors identified in HEK293T cells treated or not with zeocin by IP-MS/MS. Proteins marked with an asterisk: *: Retrieved from the databank by IIS platform [Carazzolle et al., 2014]. The mass…
View article: NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide
NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide Open
Cells are daily submitted to high levels of DNA lesions that trigger complex pathways and cellular responses by cell cycle arrest, apoptosis, alterations in transcriptional response, and the onset of DNA repair. Members of the NIMA‐related…
View article: BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells
BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells Open
Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the lar…