Priscila Pini Zenatti
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View article: Use of DNA Methylation Profiling as a Molecular Classification Tool for Paediatric Central Nervous System Tumours: A Middle‐Income Country Population–Based Study
Use of DNA Methylation Profiling as a Molecular Classification Tool for Paediatric Central Nervous System Tumours: A Middle‐Income Country Population–Based Study Open
Paediatric central nervous system (CNS) tumours are the second most common childhood malignancy and the leading cause of cancer‐related mortality in this age group. Histopathological diagnosis can be challenging, particularly for rare or a…
View article: Establishing a pediatric solid tumor PDX biobank for precision oncology research
Establishing a pediatric solid tumor PDX biobank for precision oncology research Open
Developing advanced preclinical models and targeted therapies is essential for reducing cancer-related deaths in children with solid tumors. Patient-derived xenografts (PDX) have the potential to replicate key elements of the original tumo…
View article: Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling
Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling Open
View article: Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia
Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia Open
Interleukin-7 receptor α (encoded by IL7R ) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lym…
View article: Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia
Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia Open
Insulin and insulin-like growth factors (IGFs) are mitogenic and prosurvival factors to many different cell types, including acute lymphoblastic leukemia (ALL). Circulating IGFs are bound by IGF binding proteins (IGFBPs) that regulate thei…
View article: Implementation of the asparaginase activity assessment technique for clinical use: experience of a Brazilian Center
Implementation of the asparaginase activity assessment technique for clinical use: experience of a Brazilian Center Open
Acute lymphoid leukemia is a childhood cancer that in high-income countries has event-free survival rates of 80% and global survival rates of 90%. In Brazil these rates are under 70%. This difference may be due to the implementation of sup…
View article: Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase
Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase Open
View article: Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia
Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia Open
Tubulin is one of the best validated anti-cancer targets, but most anti-tubulin agents have unfavorable therapeutic indexes. Here, we characterized the tubulin-binding activity, the mechanism of action, and the in vivo anti-leukemia effica…
View article: THE MECHANISM OF ONCOGENIC MUTATIONS IN THE JUXTAMEMBRANE AND TRANSMEMBRANE REGION OF IL7RA AND TPOR/MPL
THE MECHANISM OF ONCOGENIC MUTATIONS IN THE JUXTAMEMBRANE AND TRANSMEMBRANE REGION OF IL7RA AND TPOR/MPL Open
View article: Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity Open
TO THE EDITOR:
The receptor for interleukin-7 (IL-7) is formed by the IL7RA and the IL2RG (γc) chains. IL-7 leads to the reciprocal phosphorylation of IL7RA-associated JAK1 and γc-associated JAK3, followed by phosphorylation of IL7RA and …
View article: Low Bioavailability and High Immunogenicity of a New Brand of E. coli l-Asparaginase with Active Host Contaminating Proteins
Low Bioavailability and High Immunogenicity of a New Brand of E. coli l-Asparaginase with Active Host Contaminating Proteins Open
View article: In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models
In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models Open
View article: SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1
SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1 Open
Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea). Although initially des…